Sequence Description Alias PCC hrr evm.model.contig_2132.6 (at5g60600 : 246.0) Encodes a chloroplast-localized hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) synthase (HDS), catalyzes the formation of HMBPP from 2-C-methyl-D-erythrytol 2,4-cyclodiphosphate (MEcPP). The HDS enzyme controls the penultimate steps of the biosynthesis of IPP and dimethylallyl diphosphate (DMAPP) via the MEP pathway and may serve as a metabolic control point for SA-mediated disease resistance. In the light, the electrons required for the reaction catalyzed by HDS are directly provided by the electron flow from photosynthesis via ferredoxin. In the dark however, the enzyme requires an electron shuttle: ferredoxin-NADP<sup>+</sup> reductase.; 4-hydroxy-3-methylbut-2-enyl diphosphate synthase (HDS); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity, 4 iron, 4 sulfur cluster binding; INVOLVED IN: response to light stimulus, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, response to bacterium, systemic acquired resistance, salicylic acid mediated signaling pathway; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical (InterPro:IPR017178), 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type (InterPro:IPR004588); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (reliability: 492.0) & (original description: no original description) 0.8375762918779172 42 evm.model.contig_454.12 no hits & (original description: no original description) 0.8185376570333617 10 evm.model.contig_3395.1 no hits & (original description: no original description) 0.786518722606266 98 evm.model.contig_3381.1 no hits & (original description: no original description) 0.7672458158928773 65 evm.model.contig_2024.24 no hits & (original description: no original description) 0.7617705495717793 62 evm.model.contig_3398.2 no hits & (original description: no original description) 0.755769834974938 62 evm.model.contig_525.1 no hits & (original description: no original description) 0.7504346766887784 86 evm.model.contig_3441.19 no hits & (original description: no original description) 0.7500970912147767 38 evm.model.contig_2036.9 (original description: no original description) 0.747334347384856 34 evm.model.contig_2102.11 no hits & (original description: no original description) 0.7392494215486635 81 evm.model.contig_564.10 no hits & (original description: no original description) 0.7235321790972802 60 evm.model.contig_2072.9 no hits & (original description: no original description) 0.7065251317602622 40 evm.model.contig_2090.21 no hits & (original description: no original description) 0.6727312569120351 77