evm.model.tig00000025.24

Description : (at4g34350 : 116.0) Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; INVOLVED IN: response to antibiotic, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: LytB protein (InterPro:IPR003451); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (reliability: 232.0) & (original description: no original description)

Gene families : OG_42_0004636 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004636_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000025.24
Cluster	HCCA clusters: Cluster_1

Target	Alias	Description	ECC score	Gene Family Method
163924	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.02	Orthogroups_2024-Update
At4g34350	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase,...	0.01	Orthogroups_2024-Update
Bradi1g09710	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.02	Orthogroups_2024-Update
Brara.H01210.1	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.01	Orthogroups_2024-Update
GRMZM2G027059	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.01	Orthogroups_2024-Update
Glyma.12G046000	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.02	Orthogroups_2024-Update
LOC_Os03g52170	No alias	4-hydroxy-3-methylbut-2-enyl diphosphate reductase,...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006081	cellular aldehyde metabolic process	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006090	pyruvate metabolic process	None	Extended
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006644	phospholipid metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008610	lipid biosynthetic process	None	Extended
BP	GO:0008654	phospholipid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009240	isopentenyl diphosphate biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	None	Extended
MF	GO:0016726	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	None	Extended
BP	GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IEA	InterProScan predictions
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046490	isopentenyl diphosphate metabolic process	None	Extended
MF	GO:0046872	metal ion binding	IEA	InterProScan predictions
BP	GO:0050992	dimethylallyl diphosphate biosynthetic process	IEA	InterProScan predictions
BP	GO:0050993	dimethylallyl diphosphate metabolic process	None	Extended
MF	GO:0051745	4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090407	organophosphate biosynthetic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000062	fatty-acyl-CoA binding	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0004601	peroxidase activity	IEP	Predicted GO
MF	GO:0004602	glutathione peroxidase activity	IEP	Predicted GO
MF	GO:0005092	GDP-dissociation inhibitor activity	IEP	Predicted GO
BP	GO:0006888	ER to Golgi vesicle-mediated transport	IEP	Predicted GO
BP	GO:0006979	response to oxidative stress	IEP	Predicted GO
BP	GO:0007264	small GTPase mediated signal transduction	IEP	Predicted GO
BP	GO:0009439	cyanate metabolic process	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
BP	GO:0016226	iron-sulfur cluster assembly	IEP	Predicted GO
MF	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IEP	Predicted GO
MF	GO:0030695	GTPase regulator activity	IEP	Predicted GO
BP	GO:0031163	metallo-sulfur cluster assembly	IEP	Predicted GO
MF	GO:0033218	amide binding	IEP	Predicted GO
BP	GO:0046907	intracellular transport	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
BP	GO:0048193	Golgi vesicle transport	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
MF	GO:0051536	iron-sulfur cluster binding	IEP	Predicted GO
MF	GO:0051540	metal cluster binding	IEP	Predicted GO
BP	GO:0051641	cellular localization	IEP	Predicted GO
BP	GO:0051649	establishment of localization in cell	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0060589	nucleoside-triphosphatase regulator activity	IEP	Predicted GO
MF	GO:1901567	fatty acid derivative binding	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003451	LytB/IspH	51	130

External Links

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evm.model.tig00000025.24

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation