evm.model.tig00000237.42

Description : (o48653|dpola_orysa : 568.0) DNA polymerase alpha catalytic subunit (EC 2.7.7.7) - Oryza sativa (Rice) & (at5g67100 : 554.0) Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering.; INCURVATA2 (ICU2); FUNCTIONS IN: DNA-directed DNA polymerase activity; INVOLVED IN: negative regulation of flower development, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Zinc finger, DNA-directed DNA polymerase, family B, alpha (InterPro:IPR015088), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (TAIR:AT5G63960.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 1108.0) & (original description: no original description)

Gene families : OG_42_0006336 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0006336_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000237.42
Cluster	HCCA clusters: Cluster_152

Target	Alias	Description	ECC score	Gene Family Method
232193	No alias	DNA-directed DNA polymerases	0.01	Orthogroups_2024-Update
At5g67100	No alias	DNA polymerase alpha catalytic subunit...	0.02	Orthogroups_2024-Update
Brara.G01198.1	No alias	catalytic component *(POLA1) of DNA polymerase alpha complex	0.06	Orthogroups_2024-Update
Cre04.g214350	No alias	DNA-directed DNA polymerases	0.08	Orthogroups_2024-Update
Glyma.01G187400	No alias	DNA-directed DNA polymerases	0.06	Orthogroups_2024-Update
Kfl00349_0050	kfl00349_0050_v1.1	(o48653\|dpola_orysa : 1124.0) DNA polymerase alpha...	0.1	Orthogroups_2024-Update
Mp7g03960.1	No alias	catalytic component POLA1 of DNA polymerase alpha complex	0.02	Orthogroups_2024-Update
Pp1s257_37V6	No alias	dna polymerase alpha catalytic subunit	0.01	Orthogroups_2024-Update
Sobic.003G369200.2	No alias	catalytic component *(POLA1) of DNA polymerase alpha complex	0.02	Orthogroups_2024-Update
Solyc02g093300	No alias	DNA polymerase (AHRD V3.3 *** H9E8V2_SOLLC)	0.05	Orthogroups_2024-Update
evm.model.contig_2084.13	No alias	(o48653\|dpola_orysa : 558.0) DNA polymerase alpha...	0.07	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	InterProScan predictions
MF	GO:0001882	nucleoside binding	IEA	InterProScan predictions
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003887	DNA-directed DNA polymerase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016779	nucleotidyltransferase activity	None	Extended
MF	GO:0034061	DNA polymerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003690	double-stranded DNA binding	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Predicted GO
MF	GO:0005515	protein binding	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
BP	GO:0006220	pyrimidine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0006221	pyrimidine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006231	dTMP biosynthetic process	IEP	Predicted GO
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
BP	GO:0006281	DNA repair	IEP	Predicted GO
BP	GO:0006298	mismatch repair	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
BP	GO:0007186	G protein-coupled receptor signaling pathway	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008658	penicillin binding	IEP	Predicted GO
BP	GO:0009129	pyrimidine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009162	deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009176	pyrimidine deoxyribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009177	pyrimidine deoxyribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009265	2'-deoxyribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009394	2'-deoxyribonucleotide metabolic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
BP	GO:0010824	regulation of centrosome duplication	IEP	Predicted GO
BP	GO:0010826	negative regulation of centrosome duplication	IEP	Predicted GO
BP	GO:0010948	negative regulation of cell cycle process	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
BP	GO:0019692	deoxyribose phosphate metabolic process	IEP	Predicted GO
BP	GO:0030030	cell projection organization	IEP	Predicted GO
BP	GO:0030031	cell projection assembly	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0030983	mismatched DNA binding	IEP	Predicted GO
MF	GO:0031406	carboxylic acid binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
BP	GO:0032886	regulation of microtubule-based process	IEP	Predicted GO
BP	GO:0033043	regulation of organelle organization	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
MF	GO:0033293	monocarboxylic acid binding	IEP	Predicted GO
BP	GO:0033554	cellular response to stress	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
CC	GO:0036038	MKS complex	IEP	Predicted GO
BP	GO:0038166	angiotensin-activated signaling pathway	IEP	Predicted GO
MF	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	IEP	Predicted GO
CC	GO:0042555	MCM complex	IEP	Predicted GO
BP	GO:0043086	negative regulation of catalytic activity	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
MF	GO:0043177	organic acid binding	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043227	membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Predicted GO
BP	GO:0044092	negative regulation of molecular function	IEP	Predicted GO
CC	GO:0044441	ciliary part	IEP	Predicted GO
CC	GO:0044463	cell projection part	IEP	Predicted GO
BP	GO:0044782	cilium organization	IEP	Predicted GO
BP	GO:0045786	negative regulation of cell cycle	IEP	Predicted GO
BP	GO:0046073	dTMP metabolic process	IEP	Predicted GO
BP	GO:0046385	deoxyribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046605	regulation of centrosome cycle	IEP	Predicted GO
BP	GO:0046606	negative regulation of centrosome cycle	IEP	Predicted GO
BP	GO:0048519	negative regulation of biological process	IEP	Predicted GO
BP	GO:0048523	negative regulation of cellular process	IEP	Predicted GO
BP	GO:0050790	regulation of catalytic activity	IEP	Predicted GO
MF	GO:0050797	thymidylate synthase (FAD) activity	IEP	Predicted GO
BP	GO:0050896	response to stimulus	IEP	Predicted GO
BP	GO:0051095	regulation of helicase activity	IEP	Predicted GO
BP	GO:0051097	negative regulation of helicase activity	IEP	Predicted GO
BP	GO:0051128	regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051336	regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Predicted GO
BP	GO:0051493	regulation of cytoskeleton organization	IEP	Predicted GO
BP	GO:0051494	negative regulation of cytoskeleton organization	IEP	Predicted GO
BP	GO:0051716	cellular response to stimulus	IEP	Predicted GO
BP	GO:0060271	cilium assembly	IEP	Predicted GO
BP	GO:0065009	regulation of molecular function	IEP	Predicted GO
BP	GO:0070507	regulation of microtubule cytoskeleton organization	IEP	Predicted GO
BP	GO:0070925	organelle assembly	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
BP	GO:0120031	plasma membrane bounded cell projection assembly	IEP	Predicted GO
BP	GO:0120036	plasma membrane bounded cell projection organization	IEP	Predicted GO
CC	GO:0120038	plasma membrane bounded cell projection part	IEP	Predicted GO
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Predicted GO
BP	GO:1905774	regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR024647	DNA_pol_a_cat_su_N	21	79
IPR006133	DNA-dir_DNA_pol_B_exonuc	435	786
IPR006134	DNA-dir_DNA_pol_B_multi_dom	989	1299
IPR015088	Znf_DNA-dir_DNA_pol_B_alpha	1438	1512

External Links

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evm.model.tig00000237.42

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation