evm.model.tig00000489.16

Description : (at4g02070 : 188.0) encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH6 bound the (+T) substrate strongly, (T/G) well, and (+AAG) no better than it did a (T/A) homoduplex.; MUTS homolog 6 (MSH6); FUNCTIONS IN: damaged DNA binding; INVOLVED IN: mismatch repair; LOCATED IN: chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Msh6 (InterPro:IPR017261), DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), Tudor domain (InterPro:IPR002999); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1). & (q9xgc9|msh2_maize : 111.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 376.0) & (original description: no original description)

Gene families : OG_42_0001047 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001047_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000489.16
Cluster	HCCA clusters: Cluster_152

Target	Alias	Description	ECC score	Gene Family Method
At4g02070	No alias	DNA mismatch repair protein MSH6...	0.01	Orthogroups_2024-Update
Cre05.g235750	No alias	MUTS homolog 6	0.05	Orthogroups_2024-Update
Glyma.07G087700	No alias	MUTS homolog 7	0.01	Orthogroups_2024-Update
Kfl00153_0160	kfl00153_0160_v1.1	(at4g02070 : 834.0) encodes a DNA mismatch repair...	0.07	Orthogroups_2024-Update
Kfl00266_0120	kfl00266_0120_v1.1	(at3g24495 : 377.0) encodes a DNA mismatch repair...	0.04	Orthogroups_2024-Update
PSME_00045960-RA	No alias	(at3g24495 : 245.0) encodes a DNA mismatch repair...	0.01	Orthogroups_2024-Update
Solyc01g079520	No alias	DNA mismatch repair protein (AHRD V3.3 *** Q6DQL6_PETHY)	0.02	Orthogroups_2024-Update
Sopen01g031290	No alias	MutS domain V	0.03	Orthogroups_2024-Update
evm.model.contig_2176.1	No alias	(at4g02070 : 315.0) encodes a DNA mismatch repair...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	InterProScan predictions
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0003909	DNA ligase activity	IEP	Predicted GO
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Predicted GO
MF	GO:0004003	ATP-dependent DNA helicase activity	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
MF	GO:0008026	ATP-dependent helicase activity	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
BP	GO:0010824	regulation of centrosome duplication	IEP	Predicted GO
BP	GO:0010826	negative regulation of centrosome duplication	IEP	Predicted GO
BP	GO:0010948	negative regulation of cell cycle process	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
BP	GO:0030030	cell projection organization	IEP	Predicted GO
BP	GO:0030031	cell projection assembly	IEP	Predicted GO
BP	GO:0032886	regulation of microtubule-based process	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
CC	GO:0036038	MKS complex	IEP	Predicted GO
MF	GO:0043138	3'-5' DNA helicase activity	IEP	Predicted GO
MF	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	IEP	Predicted GO
CC	GO:0044441	ciliary part	IEP	Predicted GO
CC	GO:0044463	cell projection part	IEP	Predicted GO
BP	GO:0044782	cilium organization	IEP	Predicted GO
BP	GO:0045786	negative regulation of cell cycle	IEP	Predicted GO
BP	GO:0046605	regulation of centrosome cycle	IEP	Predicted GO
BP	GO:0046606	negative regulation of centrosome cycle	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051493	regulation of cytoskeleton organization	IEP	Predicted GO
BP	GO:0051494	negative regulation of cytoskeleton organization	IEP	Predicted GO
BP	GO:0060271	cilium assembly	IEP	Predicted GO
MF	GO:0070035	purine NTP-dependent helicase activity	IEP	Predicted GO
BP	GO:0070507	regulation of microtubule cytoskeleton organization	IEP	Predicted GO
BP	GO:0070925	organelle assembly	IEP	Predicted GO
BP	GO:0120031	plasma membrane bounded cell projection assembly	IEP	Predicted GO
BP	GO:0120036	plasma membrane bounded cell projection organization	IEP	Predicted GO
CC	GO:0120038	plasma membrane bounded cell projection part	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR007860	DNA_mmatch_repair_MutS_con_dom	583	650
IPR007696	DNA_mismatch_repair_MutS_core	792	1047
IPR007695	DNA_mismatch_repair_MutS-lik_N	444	573
IPR000432	DNA_mismatch_repair_MutS_C	1114	1220

External Links

No external refs found!

evm.model.tig00000489.16

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation