evm.model.tig00000970.30

Description : (at1g08260 : 1115.0) Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells.; TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink). & (reliability: 2230.0) & (original description: no original description)

Gene families : OG_42_0003443 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003443_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00000970.30
Cluster	HCCA clusters: Cluster_6

Target	Alias	Description	ECC score	Gene Family Method	Actions
Cre03.g179961	No alias	DNA polymerase epsilon catalytic subunit	0.03	Orthogroups_2024-Update
Kfl00061_0280	kfl00061_0280_v1.1	(at1g08260 : 1660.0) Similar to POL2A, DNA polymerase...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEA	InterProScan predictions
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003887	DNA-directed DNA polymerase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008270	zinc ion binding	IEA	InterProScan predictions
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016779	nucleotidyltransferase activity	None	Extended
MF	GO:0034061	DNA polymerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003682	chromatin binding	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
CC	GO:0005667	transcription factor complex	IEP	Predicted GO
BP	GO:0006270	DNA replication initiation	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
MF	GO:0008658	penicillin binding	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0031406	carboxylic acid binding	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
MF	GO:0033218	amide binding	IEP	Predicted GO
MF	GO:0033293	monocarboxylic acid binding	IEP	Predicted GO
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
MF	GO:0043177	organic acid binding	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006134	DNA-dir_DNA_pol_B_multi_dom	750	962
IPR013697	DNA_pol_e_suA_C	1475	1752
IPR006133	DNA-dir_DNA_pol_B_exonuc	45	372

External Links

No external refs found!

evm.model.tig00000970.30

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation