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- Sequence
- evm.model.tig00001001.13
evm.model.tig00001001.13
Description : (at1g50240 : 105.0) The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED.; FUSED (FU); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), 26S proteasome non-ATPase regulatory subunit 5 (InterPro:IPR019538), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 138334 Blast hits to 135590 proteins in 4834 species: Archae - 164; Bacteria - 15793; Metazoa - 51363; Fungi - 13983; Plants - 33508; Viruses - 544; Other Eukaryotes - 22979 (source: NCBI BLink). & (q6x4a2|cipk1_orysa : 80.9) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1) - Oryza sativa (Rice) & (reliability: 204.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Cyanophora release: evm.model.tig00001001.13 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| A4A49_18333 | No alias | mitogen-activated protein kinase kinase kinase yoda | 0.05 | Orthogroups_2024-Update | |
| Glyma.12G226300 | No alias | Protein kinase superfamily protein | 0.01 | Orthogroups_2024-Update | |
| Glyma.13G274500 | No alias | Protein kinase superfamily protein | 0.02 | Orthogroups_2024-Update | |
| HORVU5Hr1G095970.2 | No alias | protein kinase component *(SIK1) of RAM signalling... | 0.03 | Orthogroups_2024-Update | |
| Mp7g18010.1 | No alias | protein kinase (MAP4K) | 0.04 | Orthogroups_2024-Update | |
| PSME_00032646-RA | No alias | (at1g53165 : 322.0) ATMAP4K ALPHA1; FUNCTIONS IN:... | 0.01 | Orthogroups_2024-Update | |
| Potri.001G397600 | No alias | Protein kinase superfamily protein | 0.01 | Orthogroups_2024-Update | |
| Potri.011G116300 | No alias | Protein kinase superfamily protein | 0.02 | Orthogroups_2024-Update | |
| Sopen05g006920 | No alias | Protein kinase domain | 0.01 | Orthogroups_2024-Update | |
| evm.model.contig_2244.4 | No alias | (at1g69220 : 208.0) Encodes a putative serine/threonine... | 0.01 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | None | Extended |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0004672 | protein kinase activity | IEA | InterProScan predictions |
| MF | GO:0005488 | binding | None | Extended |
| MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
| BP | GO:0006464 | cellular protein modification process | None | Extended |
| BP | GO:0006468 | protein phosphorylation | IEA | InterProScan predictions |
| BP | GO:0006793 | phosphorus metabolic process | None | Extended |
| BP | GO:0006796 | phosphate-containing compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| MF | GO:0008144 | drug binding | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0016301 | kinase activity | None | Extended |
| BP | GO:0016310 | phosphorylation | None | Extended |
| MF | GO:0016740 | transferase activity | None | Extended |
| MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | None | Extended |
| MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | None | Extended |
| MF | GO:0017076 | purine nucleotide binding | None | Extended |
| BP | GO:0019538 | protein metabolic process | None | Extended |
| MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
| MF | GO:0032553 | ribonucleotide binding | None | Extended |
| MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
| MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
| MF | GO:0036094 | small molecule binding | None | Extended |
| BP | GO:0036211 | protein modification process | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043168 | anion binding | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| BP | GO:0043412 | macromolecule modification | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| BP | GO:0044267 | cellular protein metabolic process | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
| MF | GO:0140096 | catalytic activity, acting on a protein | None | Extended |
| MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| BP | GO:1901564 | organonitrogen compound metabolic process | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003774 | motor activity | IEP | Predicted GO |
| MF | GO:0003777 | microtubule motor activity | IEP | Predicted GO |
| MF | GO:0005515 | protein binding | IEP | Predicted GO |
| BP | GO:0006928 | movement of cell or subcellular component | IEP | Predicted GO |
| BP | GO:0007018 | microtubule-based movement | IEP | Predicted GO |
| MF | GO:0008017 | microtubule binding | IEP | Predicted GO |
| MF | GO:0008092 | cytoskeletal protein binding | IEP | Predicted GO |
| MF | GO:0015631 | tubulin binding | IEP | Predicted GO |
| CC | GO:0016459 | myosin complex | IEP | Predicted GO |
| MF | GO:0016462 | pyrophosphatase activity | IEP | Predicted GO |
| MF | GO:0016787 | hydrolase activity | IEP | Predicted GO |
| MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | IEP | Predicted GO |
| MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEP | Predicted GO |
| MF | GO:0017111 | nucleoside-triphosphatase activity | IEP | Predicted GO |
| CC | GO:0044430 | cytoskeletal part | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR000719 | Prot_kinase_dom | 25 | 231 |
