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  5. evm.model.tig00001221.5

evm.model.tig00001221.5


Description : (at1g22940 : 124.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 248.0) & (original description: no original description)


Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Cyanophora release: evm.model.tig00001221.5
Cluster HCCA clusters: Cluster_139

Target Alias Description ECC score Gene Family Method Actions
Pp1s163_26V6 No alias phosphomethylpyrimidine kinase 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
CC GO:0000428 DNA-directed RNA polymerase complex IEP Predicted GO
BP GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEP Predicted GO
MF GO:0003723 RNA binding IEP Predicted GO
MF GO:0004518 nuclease activity IEP Predicted GO
MF GO:0004540 ribonuclease activity IEP Predicted GO
CC GO:0005666 RNA polymerase III complex IEP Predicted GO
CC GO:0005730 nucleolus IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006351 transcription, DNA-templated IEP Predicted GO
BP GO:0006383 transcription by RNA polymerase III IEP Predicted GO
BP GO:0006396 RNA processing IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
CC GO:0008537 proteasome activator complex IEP Predicted GO
BP GO:0016070 RNA metabolic process IEP Predicted GO
BP GO:0022613 ribonucleoprotein complex biogenesis IEP Predicted GO
BP GO:0030490 maturation of SSU-rRNA IEP Predicted GO
CC GO:0030684 preribosome IEP Predicted GO
CC GO:0030686 90S preribosome IEP Predicted GO
CC GO:0030688 preribosome, small subunit precursor IEP Predicted GO
CC GO:0030880 RNA polymerase complex IEP Predicted GO
BP GO:0032774 RNA biosynthetic process IEP Predicted GO
BP GO:0034470 ncRNA processing IEP Predicted GO
BP GO:0034660 ncRNA metabolic process IEP Predicted GO
BP GO:0042254 ribosome biogenesis IEP Predicted GO
MF GO:0042802 identical protein binding IEP Predicted GO
BP GO:0044085 cellular component biogenesis IEP Predicted GO
CC GO:0044428 nuclear part IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
MF GO:0050662 coenzyme binding IEP Predicted GO
CC GO:0055029 nuclear DNA-directed RNA polymerase complex IEP Predicted GO
CC GO:0061695 transferase complex, transferring phosphorus-containing groups IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
BP GO:0097659 nucleic acid-templated transcription IEP Predicted GO
MF GO:0140098 catalytic activity, acting on RNA IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
InterPro domains Description Start Stop
IPR022998 ThiamineP_synth_TenI 39 218
No external refs found!