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  5. evm.model.tig00020516.21

evm.model.tig00020516.21


Description : (at3g48560 : 698.0) Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.; chlorsulfuron/imidazolinone resistant 1 (CSR1); FUNCTIONS IN: acetolactate synthase activity, pyruvate decarboxylase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TPP-binding enzyme, conserved site (InterPro:IPR000399), Thiamine pyrophosphate enzyme, central domain (InterPro:IPR012000), Acetolactate synthase, large subunit, biosynthetic (InterPro:IPR012846), Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (InterPro:IPR012001), Thiamine pyrophosphate enzyme, C-terminal TPP-binding (InterPro:IPR011766); BEST Arabidopsis thaliana protein match is: Thiamine pyrophosphate dependent pyruvate decarboxylase family protein (TAIR:AT5G17380.1); Has 30963 Blast hits to 30605 proteins in 2694 species: Archae - 488; Bacteria - 17421; Metazoa - 266; Fungi - 871; Plants - 599; Viruses - 25; Other Eukaryotes - 11293 (source: NCBI BLink). & (p09114|ilv2_tobac : 698.0) Acetolactate synthase 2, chloroplast precursor (EC 2.2.1.6) (Acetolactate synthase II) (Acetohydroxy-acid synthase II) (ALS II) - Nicotiana tabacum (Common tobacco) & (reliability: 1396.0) & (original description: no original description)


Gene families : OG_42_0003559 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003559_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Cyanophora release: evm.model.tig00020516.21
Cluster HCCA clusters: Cluster_26

Target Alias Description ECC score Gene Family Method Actions
Bradi3g44130 No alias chlorsulfuron/imidazolinone resistant 1 0.02 Orthogroups_2024-Update
Brara.A02375.1 No alias catalytic component of acetolactate synthase complex &... 0.02 Orthogroups_2024-Update
Glyma.13G241000 No alias chlorsulfuron/imidazolinone resistant 1 0.01 Orthogroups_2024-Update
MA_112542g0010 No alias (p09342|ilv1_tobac : 916.0) Acetolactate synthase 1,... 0.01 Orthogroups_2024-Update
Mp7g01940.1 No alias catalytic subunit of acetolactate synthase complex.... 0.01 Orthogroups_2024-Update
Potri.012G098300 No alias chlorsulfuron/imidazolinone resistant 1 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEA InterProScan predictions
MF GO:0003824 catalytic activity IEA InterProScan predictions
MF GO:0030976 thiamine pyrophosphate binding IEA InterProScan predictions
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Type GO Term Name Evidence Source
BP GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEP Predicted GO
BP GO:0000956 nuclear-transcribed mRNA catabolic process IEP Predicted GO
MF GO:0003743 translation initiation factor activity IEP Predicted GO
MF GO:0004175 endopeptidase activity IEP Predicted GO
MF GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity IEP Predicted GO
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Predicted GO
MF GO:0004813 alanine-tRNA ligase activity IEP Predicted GO
MF GO:0004827 proline-tRNA ligase activity IEP Predicted GO
MF GO:0005215 transporter activity IEP Predicted GO
CC GO:0005737 cytoplasm IEP Predicted GO
CC GO:0005852 eukaryotic translation initiation factor 3 complex IEP Predicted GO
BP GO:0005975 carbohydrate metabolic process IEP Predicted GO
BP GO:0006072 glycerol-3-phosphate metabolic process IEP Predicted GO
BP GO:0006082 organic acid metabolic process IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006399 tRNA metabolic process IEP Predicted GO
BP GO:0006401 RNA catabolic process IEP Predicted GO
BP GO:0006402 mRNA catabolic process IEP Predicted GO
BP GO:0006418 tRNA aminoacylation for protein translation IEP Predicted GO
BP GO:0006419 alanyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006433 prolyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006520 cellular amino acid metabolic process IEP Predicted GO
BP GO:0006605 protein targeting IEP Predicted GO
BP GO:0006612 protein targeting to membrane IEP Predicted GO
BP GO:0006613 cotranslational protein targeting to membrane IEP Predicted GO
BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEP Predicted GO
BP GO:0006629 lipid metabolic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006810 transport IEP Predicted GO
BP GO:0006811 ion transport IEP Predicted GO
BP GO:0006812 cation transport IEP Predicted GO
BP GO:0008150 biological_process IEP Predicted GO
BP GO:0008152 metabolic process IEP Predicted GO
MF GO:0008324 cation transmembrane transporter activity IEP Predicted GO
MF GO:0008374 O-acyltransferase activity IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009892 negative regulation of metabolic process IEP Predicted GO
BP GO:0010605 negative regulation of macromolecule metabolic process IEP Predicted GO
BP GO:0010629 negative regulation of gene expression IEP Predicted GO
MF GO:0015075 ion transmembrane transporter activity IEP Predicted GO
MF GO:0015297 antiporter activity IEP Predicted GO
MF GO:0015298 solute:cation antiporter activity IEP Predicted GO
MF GO:0015299 solute:proton antiporter activity IEP Predicted GO
MF GO:0015318 inorganic molecular entity transmembrane transporter activity IEP Predicted GO
CC GO:0016020 membrane IEP Predicted GO
BP GO:0016070 RNA metabolic process IEP Predicted GO
MF GO:0016874 ligase activity IEP Predicted GO
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Predicted GO
BP GO:0019752 carboxylic acid metabolic process IEP Predicted GO
MF GO:0022857 transmembrane transporter activity IEP Predicted GO
MF GO:0022890 inorganic cation transmembrane transporter activity IEP Predicted GO
BP GO:0030001 metal ion transport IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034613 cellular protein localization IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034660 ncRNA metabolic process IEP Predicted GO
BP GO:0043038 amino acid activation IEP Predicted GO
BP GO:0043039 tRNA aminoacylation IEP Predicted GO
BP GO:0043436 oxoacid metabolic process IEP Predicted GO
BP GO:0044238 primary metabolic process IEP Predicted GO
BP GO:0044281 small molecule metabolic process IEP Predicted GO
BP GO:0045047 protein targeting to ER IEP Predicted GO
BP GO:0046168 glycerol-3-phosphate catabolic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
MF GO:0046873 metal ion transmembrane transporter activity IEP Predicted GO
BP GO:0048519 negative regulation of biological process IEP Predicted GO
BP GO:0051179 localization IEP Predicted GO
BP GO:0051234 establishment of localization IEP Predicted GO
BP GO:0052646 alditol phosphate metabolic process IEP Predicted GO
BP GO:0055085 transmembrane transport IEP Predicted GO
BP GO:0070727 cellular macromolecule localization IEP Predicted GO
BP GO:0070972 protein localization to endoplasmic reticulum IEP Predicted GO
BP GO:0071704 organic substance metabolic process IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
BP GO:0072599 establishment of protein localization to endoplasmic reticulum IEP Predicted GO
BP GO:0072657 protein localization to membrane IEP Predicted GO
BP GO:0090150 establishment of protein localization to membrane IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
MF GO:0140098 catalytic activity, acting on RNA IEP Predicted GO
MF GO:0140101 catalytic activity, acting on a tRNA IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901136 carbohydrate derivative catabolic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
InterPro domains Description Start Stop
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom 115 267
IPR012000 Thiamin_PyroP_enz_cen_dom 284 416
IPR011766 TPP_enzyme-bd_C 485 639
No external refs found!