evm.model.tig00020563.190

Description : (at5g46210 : 239.0) Arabidopsis CULLIN4 (CUL4) forms an E3 ubiquitin ligase with the CDD complex and a common catalytic subunit RBX1 in mediating light control of development. This CUL4-based E3 ligase is essential for the repression of photomorphogenesis. The partial loss of CUL4 function resulted in a constitutive photomorphogenic phenotype with respect to morphogenesis and light-regulated gene expression. CUL4 exhibits a synergistic genetic interaction with COP10 and DET1.; cullin4 (CUL4); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin homology (InterPro:IPR016158), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin, N-terminal (InterPro:IPR001373), Cullin, conserved site (InterPro:IPR016157), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 3B (TAIR:AT1G69670.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink). & (reliability: 478.0) & (original description: no original description)

Gene families : OG_42_0003492 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003492_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Cyanophora release: evm.model.tig00020563.190
Cluster	HCCA clusters: Cluster_22

Target	Alias	Description	ECC score	Gene Family Method
Brara.F03635.1	No alias	scaffold component *(CUL4) of CUL4-DDB1 ubiquitination complexes	0.02	Orthogroups_2024-Update
Glyma.13G218500	No alias	cullin4	0.01	Orthogroups_2024-Update
Glyma.13G218600	No alias	cullin4	0.01	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	InterProScan predictions
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009057	macromolecule catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0019899	enzyme binding	None	Extended
BP	GO:0019941	modification-dependent protein catabolic process	None	Extended
MF	GO:0031625	ubiquitin protein ligase binding	IEA	InterProScan predictions
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043632	modification-dependent macromolecule catabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044265	cellular macromolecule catabolic process	None	Extended
MF	GO:0044389	ubiquitin-like protein ligase binding	None	Extended
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
BP	GO:0000413	protein peptidyl-prolyl isomerization	IEP	Predicted GO
MF	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0004357	glutamate-cysteine ligase activity	IEP	Predicted GO
MF	GO:0004674	protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0004784	superoxide dismutase activity	IEP	Predicted GO
MF	GO:0005096	GTPase activator activity	IEP	Predicted GO
CC	GO:0005783	endoplasmic reticulum	IEP	Predicted GO
BP	GO:0006352	DNA-templated transcription, initiation	IEP	Predicted GO
BP	GO:0006367	transcription initiation from RNA polymerase II promoter	IEP	Predicted GO
BP	GO:0006464	cellular protein modification process	IEP	Predicted GO
BP	GO:0006575	cellular modified amino acid metabolic process	IEP	Predicted GO
BP	GO:0006605	protein targeting	IEP	Predicted GO
BP	GO:0006612	protein targeting to membrane	IEP	Predicted GO
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006749	glutathione metabolic process	IEP	Predicted GO
BP	GO:0006750	glutathione biosynthetic process	IEP	Predicted GO
BP	GO:0006790	sulfur compound metabolic process	IEP	Predicted GO
BP	GO:0006801	superoxide metabolic process	IEP	Predicted GO
MF	GO:0008047	enzyme activator activity	IEP	Predicted GO
MF	GO:0008312	7S RNA binding	IEP	Predicted GO
MF	GO:0008641	ubiquitin-like modifier activating enzyme activity	IEP	Predicted GO
MF	GO:0016209	antioxidant activity	IEP	Predicted GO
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Predicted GO
MF	GO:0016853	isomerase activity	IEP	Predicted GO
MF	GO:0016859	cis-trans isomerase activity	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016877	ligase activity, forming carbon-sulfur bonds	IEP	Predicted GO
MF	GO:0016879	ligase activity, forming carbon-nitrogen bonds	IEP	Predicted GO
MF	GO:0016881	acid-amino acid ligase activity	IEP	Predicted GO
BP	GO:0018193	peptidyl-amino acid modification	IEP	Predicted GO
BP	GO:0018208	peptidyl-proline modification	IEP	Predicted GO
BP	GO:0019184	nonribosomal peptide biosynthetic process	IEP	Predicted GO
MF	GO:0030695	GTPase regulator activity	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0036211	protein modification process	IEP	Predicted GO
BP	GO:0042398	cellular modified amino acid biosynthetic process	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
BP	GO:0043412	macromolecule modification	IEP	Predicted GO
BP	GO:0044272	sulfur compound biosynthetic process	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
BP	GO:0045047	protein targeting to ER	IEP	Predicted GO
CC	GO:0048500	signal recognition particle	IEP	Predicted GO
MF	GO:0060589	nucleoside-triphosphatase regulator activity	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Predicted GO
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Predicted GO
BP	GO:0072657	protein localization to membrane	IEP	Predicted GO
BP	GO:0090150	establishment of protein localization to membrane	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR019559	Cullin_neddylation_domain	115	175
IPR001373	Cullin_N	2	84

External Links

No external refs found!

evm.model.tig00020563.190

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation