evm.model.tig00020629.95


Description : (at1g78870 : 211.0) UBC35/UBC13A encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UBC35/UBC13A can form diubiquitin and triubiquitin chains in combination with MMZ1,2,3,4/(UEV1A,B,C,D) in vitro. It can also functionally complement an mms2 ubc13 mutation in budding yeast by increasing the double mutant's viability in the presence of the DNA damaging agent MMS, when it is co-expressed with MMZ / UEV1 genes. A wild type phenotype is restored with MMZ3/UEV1C and MMZ4/UEV1D, but only partial complementation is achieved with MMZ1/UEV1A or MMZ2/UEV1B.; ubiquitin-conjugating enzyme 35 (UBC35); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: root epidermal cell differentiation, response to cadmium ion, postreplication repair, response to iron ion, ubiquitin-dependent protein catabolic process; LOCATED IN: UBC13-MMS2 complex; EXPRESSED IN: male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 36 (TAIR:AT1G16890.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). & (p25866|ubc2_wheat : 98.2) Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) - Triticum aestivum (Wheat) & (reliability: 422.0) & (original description: no original description)


Gene families : OG_42_0002519 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002519_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Cyanophora release: evm.model.tig00020629.95
Cluster HCCA clusters: Cluster_135

Target Alias Description ECC score Gene Family Method Actions
116003 No alias ubiquitin-conjugating enzyme 35 0.01 Orthogroups_2024-Update
HORVU5Hr1G055360.2 No alias E2 ubiquitin-conjugating enzyme 0.03 Orthogroups_2024-Update
Kfl00591_0110 kfl00591_0110_v1.1 (at1g78870 : 291.0) UBC35/UBC13A encodes a protein that... 0.03 Orthogroups_2024-Update
Seita.2G173600.1 No alias E2 ubiquitin-conjugating enzyme 0.01 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence

Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Predicted GO
MF GO:0001882 nucleoside binding IEP Predicted GO
MF GO:0001883 purine nucleoside binding IEP Predicted GO
MF GO:0003674 molecular_function IEP Predicted GO
MF GO:0003824 catalytic activity IEP Predicted GO
MF GO:0003924 GTPase activity IEP Predicted GO
MF GO:0004129 cytochrome-c oxidase activity IEP Predicted GO
MF GO:0005488 binding IEP Predicted GO
MF GO:0005525 GTP binding IEP Predicted GO
CC GO:0005575 cellular_component IEP Predicted GO
CC GO:0005643 nuclear pore IEP Predicted GO
CC GO:0005681 spliceosomal complex IEP Predicted GO
CC GO:0005743 mitochondrial inner membrane IEP Predicted GO
CC GO:0005751 mitochondrial respiratory chain complex IV IEP Predicted GO
BP GO:0006605 protein targeting IEP Predicted GO
BP GO:0006612 protein targeting to membrane IEP Predicted GO
BP GO:0006613 cotranslational protein targeting to membrane IEP Predicted GO
BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEP Predicted GO
BP GO:0007155 cell adhesion IEP Predicted GO
MF GO:0008312 7S RNA binding IEP Predicted GO
MF GO:0008324 cation transmembrane transporter activity IEP Predicted GO
BP GO:0008380 RNA splicing IEP Predicted GO
MF GO:0009055 electron transfer activity IEP Predicted GO
MF GO:0015002 heme-copper terminal oxidase activity IEP Predicted GO
MF GO:0015077 monovalent inorganic cation transmembrane transporter activity IEP Predicted GO
MF GO:0015078 proton transmembrane transporter activity IEP Predicted GO
MF GO:0016462 pyrophosphatase activity IEP Predicted GO
MF GO:0016491 oxidoreductase activity IEP Predicted GO
MF GO:0016675 oxidoreductase activity, acting on a heme group of donors IEP Predicted GO
MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor IEP Predicted GO
MF GO:0016787 hydrolase activity IEP Predicted GO
MF GO:0016817 hydrolase activity, acting on acid anhydrides IEP Predicted GO
MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEP Predicted GO
MF GO:0017076 purine nucleotide binding IEP Predicted GO
MF GO:0017111 nucleoside-triphosphatase activity IEP Predicted GO
MF GO:0019001 guanyl nucleotide binding IEP Predicted GO
BP GO:0019725 cellular homeostasis IEP Predicted GO
CC GO:0019866 organelle inner membrane IEP Predicted GO
BP GO:0022610 biological adhesion IEP Predicted GO
MF GO:0022890 inorganic cation transmembrane transporter activity IEP Predicted GO
CC GO:0031090 organelle membrane IEP Predicted GO
CC GO:0031966 mitochondrial membrane IEP Predicted GO
MF GO:0032549 ribonucleoside binding IEP Predicted GO
MF GO:0032550 purine ribonucleoside binding IEP Predicted GO
MF GO:0032553 ribonucleotide binding IEP Predicted GO
MF GO:0032555 purine ribonucleotide binding IEP Predicted GO
MF GO:0032561 guanyl ribonucleotide binding IEP Predicted GO
CC GO:0032991 protein-containing complex IEP Predicted GO
BP GO:0033365 protein localization to organelle IEP Predicted GO
BP GO:0034613 cellular protein localization IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
MF GO:0036094 small molecule binding IEP Predicted GO
BP GO:0042592 homeostatic process IEP Predicted GO
MF GO:0043167 ion binding IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044428 nuclear part IEP Predicted GO
CC GO:0044429 mitochondrial part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044455 mitochondrial membrane part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
BP GO:0045047 protein targeting to ER IEP Predicted GO
CC GO:0045277 respiratory chain complex IV IEP Predicted GO
BP GO:0045454 cell redox homeostasis IEP Predicted GO
BP GO:0046907 intracellular transport IEP Predicted GO
CC GO:0048500 signal recognition particle IEP Predicted GO
BP GO:0051641 cellular localization IEP Predicted GO
BP GO:0051649 establishment of localization in cell IEP Predicted GO
BP GO:0065008 regulation of biological quality IEP Predicted GO
CC GO:0070069 cytochrome complex IEP Predicted GO
BP GO:0070727 cellular macromolecule localization IEP Predicted GO
BP GO:0070972 protein localization to endoplasmic reticulum IEP Predicted GO
BP GO:0072594 establishment of protein localization to organelle IEP Predicted GO
BP GO:0072599 establishment of protein localization to endoplasmic reticulum IEP Predicted GO
BP GO:0072657 protein localization to membrane IEP Predicted GO
BP GO:0090150 establishment of protein localization to membrane IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0097367 carbohydrate derivative binding IEP Predicted GO
CC GO:0098798 mitochondrial protein complex IEP Predicted GO
CC GO:0098800 inner mitochondrial membrane protein complex IEP Predicted GO
CC GO:0098803 respiratory chain complex IEP Predicted GO
MF GO:1901265 nucleoside phosphate binding IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO
CC GO:1990904 ribonucleoprotein complex IEP Predicted GO
InterPro domains Description Start Stop
IPR000608 UBQ-conjugat_E2 58 118
IPR000608 UBQ-conjugat_E2 8 57
No external refs found!