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  5. Kfl00018_0510

Kfl00018_0510 (kfl00018_0510_v1.1,...)


Aliases : kfl00018_0510_v1.1, kfl00018_0510_v1.1

Description : (at1g31230 : 1123.0) Encodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.; aspartate kinase-homoserine dehydrogenase i (AK-HSDH I); FUNCTIONS IN: homoserine dehydrogenase activity, aspartate kinase activity; INVOLVED IN: aspartate family amino acid biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Homoserine dehydrogenase, catalytic (InterPro:IPR001342), Amino acid-binding ACT (InterPro:IPR002912), Aspartate/homoserine dehydrogenase, NAD-binding (InterPro:IPR005106), Aspartate kinase, conserved site (InterPro:IPR018042), Bifunctional aspartokinase/homoserine dehydrogenase I (InterPro:IPR011147), NAD(P)-binding domain (InterPro:IPR016040), Aspartate kinase domain (InterPro:IPR001341), Homoserine dehydrogenase, conserved site (InterPro:IPR019811); BEST Arabidopsis thaliana protein match is: aspartate kinase-homoserine dehydrogenase ii (TAIR:AT4G19710.2); Has 17266 Blast hits to 16993 proteins in 2572 species: Archae - 397; Bacteria - 11403; Metazoa - 7; Fungi - 300; Plants - 257; Viruses - 0; Other Eukaryotes - 4902 (source: NCBI BLink). & (p49079|akh1_maize : 1072.0) Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplast precursor (AK-HD 1) (AK-HSDH 1) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)] - Zea mays (Maize) & (reliability: 2208.0) & (original description: no original description)


Gene families : OG_42_0003092 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003092_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Klebsormidium release: Kfl00018_0510
Cluster HCCA clusters: Cluster_123

Target Alias Description ECC score Gene Family Method Actions
Seita.2G165800.1 No alias bifunctional homoserine dehydrogenase and aspartate... 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source
BP GO:0006520 cellular amino acid metabolic process IEA InterProScan predictions
MF GO:0016491 oxidoreductase activity IEA InterProScan predictions
MF GO:0050661 NADP binding IEA InterProScan predictions
BP GO:0055114 oxidation-reduction process IEA InterProScan predictions
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Type GO Term Name Evidence Source
BP GO:0000105 histidine biosynthetic process IEP Predicted GO
MF GO:0000287 magnesium ion binding IEP Predicted GO
MF GO:0004055 argininosuccinate synthase activity IEP Predicted GO
MF GO:0004590 orotidine-5'-phosphate decarboxylase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0004749 ribose phosphate diphosphokinase activity IEP Predicted GO
BP GO:0006090 pyruvate metabolic process IEP Predicted GO
BP GO:0006096 glycolytic process IEP Predicted GO
BP GO:0006165 nucleoside diphosphate phosphorylation IEP Predicted GO
BP GO:0006206 pyrimidine nucleobase metabolic process IEP Predicted GO
BP GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process IEP Predicted GO
BP GO:0006525 arginine metabolic process IEP Predicted GO
BP GO:0006526 arginine biosynthetic process IEP Predicted GO
BP GO:0006547 histidine metabolic process IEP Predicted GO
BP GO:0006629 lipid metabolic process IEP Predicted GO
BP GO:0006694 steroid biosynthetic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006733 oxidoreduction coenzyme metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006757 ATP generation from ADP IEP Predicted GO
MF GO:0008168 methyltransferase activity IEP Predicted GO
BP GO:0008202 steroid metabolic process IEP Predicted GO
BP GO:0008652 cellular amino acid biosynthetic process IEP Predicted GO
BP GO:0009058 biosynthetic process IEP Predicted GO
BP GO:0009064 glutamine family amino acid metabolic process IEP Predicted GO
BP GO:0009072 aromatic amino acid family metabolic process IEP Predicted GO
BP GO:0009073 aromatic amino acid family biosynthetic process IEP Predicted GO
BP GO:0009084 glutamine family amino acid biosynthetic process IEP Predicted GO
BP GO:0009112 nucleobase metabolic process IEP Predicted GO
BP GO:0009116 nucleoside metabolic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009132 nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009135 purine nucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009165 nucleotide biosynthetic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009179 purine ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0009185 ribonucleoside diphosphate metabolic process IEP Predicted GO
BP GO:0016052 carbohydrate catabolic process IEP Predicted GO
BP GO:0016053 organic acid biosynthetic process IEP Predicted GO
BP GO:0016579 protein deubiquitination IEP Predicted GO
MF GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEP Predicted GO
MF GO:0016741 transferase activity, transferring one-carbon groups IEP Predicted GO
MF GO:0016778 diphosphotransferase activity IEP Predicted GO
MF GO:0016831 carboxy-lyase activity IEP Predicted GO
MF GO:0016879 ligase activity, forming carbon-nitrogen bonds IEP Predicted GO
BP GO:0018130 heterocycle biosynthetic process IEP Predicted GO
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Predicted GO
BP GO:0019362 pyridine nucleotide metabolic process IEP Predicted GO
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Predicted GO
BP GO:0019438 aromatic compound biosynthetic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
MF GO:0019783 ubiquitin-like protein-specific protease activity IEP Predicted GO
BP GO:0019856 pyrimidine nucleobase biosynthetic process IEP Predicted GO
MF GO:0030955 potassium ion binding IEP Predicted GO
MF GO:0031420 alkali metal ion binding IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
BP GO:0034654 nucleobase-containing compound biosynthetic process IEP Predicted GO
MF GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEP Predicted GO
BP GO:0042866 pyruvate biosynthetic process IEP Predicted GO
BP GO:0044249 cellular biosynthetic process IEP Predicted GO
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Predicted GO
BP GO:0044283 small molecule biosynthetic process IEP Predicted GO
BP GO:0046031 ADP metabolic process IEP Predicted GO
BP GO:0046112 nucleobase biosynthetic process IEP Predicted GO
BP GO:0046394 carboxylic acid biosynthetic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Predicted GO
BP GO:0046939 nucleotide phosphorylation IEP Predicted GO
BP GO:0052803 imidazole-containing compound metabolic process IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0070646 protein modification by small protein removal IEP Predicted GO
BP GO:0072524 pyridine-containing compound metabolic process IEP Predicted GO
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Predicted GO
BP GO:0072527 pyrimidine-containing compound metabolic process IEP Predicted GO
BP GO:0072528 pyrimidine-containing compound biosynthetic process IEP Predicted GO
BP GO:0090407 organophosphate biosynthetic process IEP Predicted GO
MF GO:0101005 ubiquitinyl hydrolase activity IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
BP GO:1901362 organic cyclic compound biosynthetic process IEP Predicted GO
BP GO:1901566 organonitrogen compound biosynthetic process IEP Predicted GO
BP GO:1901576 organic substance biosynthetic process IEP Predicted GO
BP GO:1901605 alpha-amino acid metabolic process IEP Predicted GO
BP GO:1901607 alpha-amino acid biosynthetic process IEP Predicted GO
BP GO:1901657 glycosyl compound metabolic process IEP Predicted GO
InterPro domains Description Start Stop
IPR001048 Asp/Glu/Uridylate_kinase 112 408
IPR001342 HDH_cat 748 946
IPR002912 ACT_dom 457 509
IPR002912 ACT_dom 539 587
IPR005106 Asp/hSer_DH_NAD-bd 605 740
No external refs found!