Kfl00059_0170 (kfl00059_0170_v1.1)

Aliases : kfl00059_0170_v1.1

Description : (at3g01120 : 523.0) encodes a cystathionine gamma-synthase, which performs the first committed step in methionine biosynthesis. A conserved motif of 13 amino acids in the first exon is required for posttranscriptional autoregulation. This enzyme shares the same substrate as threonine synthase (TS) and its absence transcriptionally affects 8 genes in the genome.; METHIONINE OVERACCUMULATION 1 (MTO1); FUNCTIONS IN: cystathionine gamma-synthase activity; INVOLVED IN: methionine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT1G33320.1); Has 21364 Blast hits to 20702 proteins in 2452 species: Archae - 220; Bacteria - 11705; Metazoa - 241; Fungi - 842; Plants - 284; Viruses - 13; Other Eukaryotes - 8059 (source: NCBI BLink). & (reliability: 1046.0) & (original description: no original description)

Gene families : OG_42_0001443 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001443_tree

Sequence : coding (download), protein (download)

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Type	Description	Actions
Neighborhood	Klebsormidium release: Kfl00059_0170
Cluster	HCCA clusters: Cluster_64

Target	Alias	Description	ECC score	Gene Family Method
A4A49_62545	No alias	cystathionine gamma-synthase 1, chloroplastic	0.02	Orthogroups_2024-Update
At1g33320	No alias	Probable cystathionine gamma-synthase 2...	0.03	Orthogroups_2024-Update
Bradi1g61260	No alias	Pyridoxal phosphate (PLP)-dependent transferases...	0.02	Orthogroups_2024-Update
evm.model.tig00021319.47	No alias	(at3g01120 : 138.0) encodes a cystathionine...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0008144	drug binding	None	Extended
MF	GO:0019842	vitamin binding	None	Extended
MF	GO:0030170	pyridoxal phosphate binding	IEA	InterProScan predictions
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
MF	GO:0070279	vitamin B6 binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0001871	pattern binding	IEP	Predicted GO
MF	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity	IEP	Predicted GO
BP	GO:0006694	steroid biosynthetic process	IEP	Predicted GO
BP	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0008173	RNA methyltransferase activity	IEP	Predicted GO
BP	GO:0008202	steroid metabolic process	IEP	Predicted GO
MF	GO:0008536	Ran GTPase binding	IEP	Predicted GO
BP	GO:0009116	nucleoside metabolic process	IEP	Predicted GO
MF	GO:0016229	steroid dehydrogenase activity	IEP	Predicted GO
MF	GO:0017016	Ras GTPase binding	IEP	Predicted GO
CC	GO:0019008	molybdopterin synthase complex	IEP	Predicted GO
BP	GO:0019720	Mo-molybdopterin cofactor metabolic process	IEP	Predicted GO
MF	GO:0019899	enzyme binding	IEP	Predicted GO
MF	GO:0030246	carbohydrate binding	IEP	Predicted GO
MF	GO:0030247	polysaccharide binding	IEP	Predicted GO
MF	GO:0031267	small GTPase binding	IEP	Predicted GO
MF	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
BP	GO:0043545	molybdopterin cofactor metabolic process	IEP	Predicted GO
MF	GO:0051020	GTPase binding	IEP	Predicted GO
BP	GO:0051189	prosthetic group metabolic process	IEP	Predicted GO
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
BP	GO:1901657	glycosyl compound metabolic process	IEP	Predicted GO
MF	GO:2001070	starch binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000277	Cys/Met-Metab_PyrdxlP-dep_enz	139	521

External Links

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Kfl00059_0170 (kfl00059_0170_v1.1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation