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  5. Kfl00066_0210

Kfl00066_0210 (kfl00066_0210_v1.1)


Aliases : kfl00066_0210_v1.1

Description : (at4g22970 : 243.0) Encodes a separase (ESP), homologous to human and mouse separase protein. Separase is a capase family protease required for the release of sister chromatid cohesion during meiosis and mitosis. Arabidopsis separase contains a predicted 2Fe2S-ferredoxin domain that is not present in the proteins of other organisms. Also contains a putative EF-hand calcium binding domain. Mutant seeds exhibited embryo arrest at the globular stage. The endosperm also exhibited a weak titan-like phenotype. Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exhibited alterations in chromosome segregation during meiosis I and II that resulted in polyads containing from one to eight microspores. Plays an essential role in embryo development. Required for the removal of cohesin from meiotic chromosomes and establishment of meiotic nuclear domains. This gene was also identified through the rsw4 mutant. Lines carrying recessive, temperature-sensitive mutations exhibit reduced anisotropic growth at 30 degrees Celsius. Microtubules and cellulose microfibrils are not depleted or disoriented in the mutants at the restrictive temperature.; homolog of separase (ESP); FUNCTIONS IN: peptidase activity; INVOLVED IN: meiotic chromosome separation, chromosome separation, embryo development ending in seed dormancy, positive regulation of sister chromatid cohesion, endosperm development; LOCATED IN: nucleus; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C50, separase (InterPro:IPR005314); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT5G28550.1). & (reliability: 486.0) & (original description: no original description)


Gene families : OG_42_0004157 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004157_tree

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Klebsormidium release: Kfl00066_0210
Cluster HCCA clusters: Cluster_38

Target Alias Description ECC score Gene Family Method Actions
Brara.A01307.1 No alias protease separase *(AESP) & separase *(ESP1) 0.02 Orthogroups_2024-Update
Cre01.g029200 No alias homolog of separase 0.05 Orthogroups_2024-Update
Glyma.08G184200 No alias homolog of separase 0.04 Orthogroups_2024-Update
Glyma.15G048100 No alias homolog of separase 0.04 Orthogroups_2024-Update
Sobic.004G095200.1 No alias protease separase *(AESP) & separase *(ESP1) 0.03 Orthogroups_2024-Update
evm.model.contig_2500.8 No alias (at4g22970 : 114.0) Encodes a separase (ESP), homologous... 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Predicted GO
MF GO:0003678 DNA helicase activity IEP Predicted GO
MF GO:0003682 chromatin binding IEP Predicted GO
MF GO:0003887 DNA-directed DNA polymerase activity IEP Predicted GO
MF GO:0004003 ATP-dependent DNA helicase activity IEP Predicted GO
MF GO:0004386 helicase activity IEP Predicted GO
MF GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEP Predicted GO
MF GO:0005524 ATP binding IEP Predicted GO
CC GO:0005634 nucleus IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006259 DNA metabolic process IEP Predicted GO
BP GO:0006260 DNA replication IEP Predicted GO
BP GO:0006270 DNA replication initiation IEP Predicted GO
BP GO:0006275 regulation of DNA replication IEP Predicted GO
BP GO:0006281 DNA repair IEP Predicted GO
BP GO:0006333 chromatin assembly or disassembly IEP Predicted GO
BP GO:0006515 protein quality control for misfolded or incompletely synthesized proteins IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006974 cellular response to DNA damage stimulus IEP Predicted GO
MF GO:0008026 ATP-dependent helicase activity IEP Predicted GO
MF GO:0008094 DNA-dependent ATPase activity IEP Predicted GO
MF GO:0008144 drug binding IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0010498 proteasomal protein catabolic process IEP Predicted GO
MF GO:0016725 oxidoreductase activity, acting on CH or CH2 groups IEP Predicted GO
MF GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor IEP Predicted GO
MF GO:0017076 purine nucleotide binding IEP Predicted GO
BP GO:0030163 protein catabolic process IEP Predicted GO
MF GO:0030554 adenyl nucleotide binding IEP Predicted GO
BP GO:0031144 proteasome localization IEP Predicted GO
BP GO:0031503 protein-containing complex localization IEP Predicted GO
MF GO:0032553 ribonucleotide binding IEP Predicted GO
MF GO:0032555 purine ribonucleotide binding IEP Predicted GO
MF GO:0032559 adenyl ribonucleotide binding IEP Predicted GO
BP GO:0033554 cellular response to stress IEP Predicted GO
MF GO:0034061 DNA polymerase activity IEP Predicted GO
BP GO:0034629 cellular protein-containing complex localization IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
MF GO:0036094 small molecule binding IEP Predicted GO
MF GO:0042623 ATPase activity, coupled IEP Predicted GO
MF GO:0043138 3'-5' DNA helicase activity IEP Predicted GO
MF GO:0043140 ATP-dependent 3'-5' DNA helicase activity IEP Predicted GO
BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEP Predicted GO
MF GO:0043167 ion binding IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
CC GO:0043226 organelle IEP Predicted GO
CC GO:0043227 membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043231 intracellular membrane-bounded organelle IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0051052 regulation of DNA metabolic process IEP Predicted GO
BP GO:0051716 cellular response to stimulus IEP Predicted GO
MF GO:0061731 ribonucleoside-diphosphate reductase activity IEP Predicted GO
MF GO:0070035 purine NTP-dependent helicase activity IEP Predicted GO
BP GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0097367 carbohydrate derivative binding IEP Predicted GO
MF GO:0140097 catalytic activity, acting on DNA IEP Predicted GO
MF GO:1901265 nucleoside phosphate binding IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO

No InterPro domains available for this sequence

No external refs found!