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  5. Kfl00072_0060

Kfl00072_0060 (kfl00072_0060_v1.1,...)


Aliases : kfl00072_0060_v1.1, kfl00072_0060_v1.1

Description : (at1g57820 : 631.0) Encodes a 645-amino acid methylcytosine-binding protein with a PHD domain, two RING finger domains, and an SRA domain that is involved in centromere heterochromatinization. This protein functions as an E3 ubiquitin ligase in vitro. The protein has been shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the former. It plays a role in the establishment/maintenance of chromatin structure during cell division and is localized in the nucleus. Plants over-expressing VIM1/ORTH2 show an inhibition in root growth and a delay in flowering. Both over-expression of GFP:ORTH2 and loss of ORTH2/VIM1 lead to decreased levels of DNA methylation. GFP:ORTH2 over-expressers also have increased levels of FWA transcripts.; VARIANT IN METHYLATION 1 (VIM1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), SRA-YDG (InterPro:IPR003105), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: zinc finger (C3HC4-type RING finger) family protein (TAIR:AT1G57800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). & (reliability: 1262.0) & (original description: no original description)


Gene families : OG_42_0002900 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002900_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Klebsormidium release: Kfl00072_0060
Cluster HCCA clusters: Cluster_38

Target Alias Description ECC score Gene Family Method Actions
At1g57820 No alias E3 ubiquitin-protein ligase ORTHRUS 2... 0.05 Orthogroups_2024-Update
Brara.G02568.1 No alias regulatory E3 ubiquitin ligase (ORTH/VIM) of... 0.02 Orthogroups_2024-Update
Cre03.g163850 No alias Zinc finger (C3HC4-type RING finger) family protein 0.09 Orthogroups_2024-Update
Glyma.02G309100 No alias Zinc finger (C3HC4-type RING finger) family protein 0.02 Orthogroups_2024-Update
Glyma.14G003700 No alias Zinc finger (C3HC4-type RING finger) family protein 0.04 Orthogroups_2024-Update
Solyc05g023680 No alias RING-finger E3 ubiquitin ligase, putative (AHRD V3.3 ***... 0.07 Orthogroups_2024-Update
Sopen05g018290 No alias SAD/SRA domain 0.02 Orthogroups_2024-Update
evm.model.tig00001024.15 No alias (at1g57820 : 133.0) Encodes a 645-amino acid... 0.05 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Predicted GO
BP GO:0000723 telomere maintenance IEP Predicted GO
BP GO:0000724 double-strand break repair via homologous recombination IEP Predicted GO
BP GO:0000725 recombinational repair IEP Predicted GO
CC GO:0000781 chromosome, telomeric region IEP Predicted GO
CC GO:0000784 nuclear chromosome, telomeric region IEP Predicted GO
CC GO:0000796 condensin complex IEP Predicted GO
MF GO:0003676 nucleic acid binding IEP Predicted GO
MF GO:0003677 DNA binding IEP Predicted GO
MF GO:0003678 DNA helicase activity IEP Predicted GO
MF GO:0003689 DNA clamp loader activity IEP Predicted GO
MF GO:0003887 DNA-directed DNA polymerase activity IEP Predicted GO
MF GO:0003896 DNA primase activity IEP Predicted GO
MF GO:0003899 DNA-directed 5'-3' RNA polymerase activity IEP Predicted GO
MF GO:0004003 ATP-dependent DNA helicase activity IEP Predicted GO
MF GO:0004386 helicase activity IEP Predicted GO
MF GO:0005488 binding IEP Predicted GO
MF GO:0005524 ATP binding IEP Predicted GO
CC GO:0005634 nucleus IEP Predicted GO
CC GO:0005663 DNA replication factor C complex IEP Predicted GO
CC GO:0005694 chromosome IEP Predicted GO
BP GO:0006139 nucleobase-containing compound metabolic process IEP Predicted GO
BP GO:0006259 DNA metabolic process IEP Predicted GO
BP GO:0006260 DNA replication IEP Predicted GO
BP GO:0006269 DNA replication, synthesis of RNA primer IEP Predicted GO
BP GO:0006270 DNA replication initiation IEP Predicted GO
BP GO:0006281 DNA repair IEP Predicted GO
BP GO:0006298 mismatch repair IEP Predicted GO
BP GO:0006302 double-strand break repair IEP Predicted GO
BP GO:0006323 DNA packaging IEP Predicted GO
BP GO:0006401 RNA catabolic process IEP Predicted GO
BP GO:0006725 cellular aromatic compound metabolic process IEP Predicted GO
BP GO:0006807 nitrogen compound metabolic process IEP Predicted GO
BP GO:0006950 response to stress IEP Predicted GO
BP GO:0006974 cellular response to DNA damage stimulus IEP Predicted GO
BP GO:0006996 organelle organization IEP Predicted GO
BP GO:0007062 sister chromatid cohesion IEP Predicted GO
BP GO:0007064 mitotic sister chromatid cohesion IEP Predicted GO
BP GO:0007076 mitotic chromosome condensation IEP Predicted GO
MF GO:0008026 ATP-dependent helicase activity IEP Predicted GO
MF GO:0008094 DNA-dependent ATPase activity IEP Predicted GO
MF GO:0008144 drug binding IEP Predicted GO
BP GO:0009058 biosynthetic process IEP Predicted GO
BP GO:0009059 macromolecule biosynthetic process IEP Predicted GO
BP GO:0009987 cellular process IEP Predicted GO
BP GO:0016043 cellular component organization IEP Predicted GO
MF GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEP Predicted GO
MF GO:0016779 nucleotidyltransferase activity IEP Predicted GO
MF GO:0016846 carbon-sulfur lyase activity IEP Predicted GO
MF GO:0017076 purine nucleotide binding IEP Predicted GO
MF GO:0019207 kinase regulator activity IEP Predicted GO
MF GO:0019887 protein kinase regulator activity IEP Predicted GO
BP GO:0022402 cell cycle process IEP Predicted GO
BP GO:0030261 chromosome condensation IEP Predicted GO
MF GO:0030554 adenyl nucleotide binding IEP Predicted GO
MF GO:0030983 mismatched DNA binding IEP Predicted GO
CC GO:0031390 Ctf18 RFC-like complex IEP Predicted GO
BP GO:0032200 telomere organization IEP Predicted GO
CC GO:0032299 ribonuclease H2 complex IEP Predicted GO
MF GO:0032553 ribonucleotide binding IEP Predicted GO
MF GO:0032555 purine ribonucleotide binding IEP Predicted GO
MF GO:0032559 adenyl ribonucleotide binding IEP Predicted GO
MF GO:0033170 protein-DNA loading ATPase activity IEP Predicted GO
BP GO:0033554 cellular response to stress IEP Predicted GO
MF GO:0034061 DNA polymerase activity IEP Predicted GO
MF GO:0034062 5'-3' RNA polymerase activity IEP Predicted GO
BP GO:0034641 cellular nitrogen compound metabolic process IEP Predicted GO
BP GO:0034645 cellular macromolecule biosynthetic process IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
MF GO:0036094 small molecule binding IEP Predicted GO
MF GO:0042623 ATPase activity, coupled IEP Predicted GO
MF GO:0043138 3'-5' DNA helicase activity IEP Predicted GO
MF GO:0043140 ATP-dependent 3'-5' DNA helicase activity IEP Predicted GO
MF GO:0043167 ion binding IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
CC GO:0043226 organelle IEP Predicted GO
CC GO:0043227 membrane-bounded organelle IEP Predicted GO
CC GO:0043229 intracellular organelle IEP Predicted GO
CC GO:0043231 intracellular membrane-bounded organelle IEP Predicted GO
BP GO:0044237 cellular metabolic process IEP Predicted GO
BP GO:0044238 primary metabolic process IEP Predicted GO
BP GO:0044249 cellular biosynthetic process IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
CC GO:0044422 organelle part IEP Predicted GO
CC GO:0044424 intracellular part IEP Predicted GO
CC GO:0044427 chromosomal part IEP Predicted GO
CC GO:0044446 intracellular organelle part IEP Predicted GO
CC GO:0044464 cell part IEP Predicted GO
CC GO:0044815 DNA packaging complex IEP Predicted GO
BP GO:0046483 heterocycle metabolic process IEP Predicted GO
BP GO:0050896 response to stimulus IEP Predicted GO
BP GO:0051276 chromosome organization IEP Predicted GO
BP GO:0051716 cellular response to stimulus IEP Predicted GO
BP GO:0060249 anatomical structure homeostasis IEP Predicted GO
MF GO:0070035 purine NTP-dependent helicase activity IEP Predicted GO
BP GO:0071704 organic substance metabolic process IEP Predicted GO
BP GO:0071840 cellular component organization or biogenesis IEP Predicted GO
BP GO:0090304 nucleic acid metabolic process IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0097367 carbohydrate derivative binding IEP Predicted GO
MF GO:0097747 RNA polymerase activity IEP Predicted GO
CC GO:0098687 chromosomal region IEP Predicted GO
MF GO:0140097 catalytic activity, acting on DNA IEP Predicted GO
MF GO:1901265 nucleoside phosphate binding IEP Predicted GO
BP GO:1901360 organic cyclic compound metabolic process IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO
BP GO:1901576 organic substance biosynthetic process IEP Predicted GO
BP GO:1903047 mitotic cell cycle process IEP Predicted GO
InterPro domains Description Start Stop
IPR003105 SRA_YDG 255 403
IPR027370 Znf-RING_LisH 124 162
IPR027370 Znf-RING_LisH 488 516
No external refs found!