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  5. Kfl00272_0030

Kfl00272_0030 (kfl00272_0030_v1.1)


Aliases : kfl00272_0030_v1.1

Description : (at1g74040 : 762.0) Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).; 2-isopropylmalate synthase 1 (IMS1); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: methylthioalkylmalate synthase-like 4 (TAIR:AT1G18500.1); Has 16891 Blast hits to 16883 proteins in 2449 species: Archae - 499; Bacteria - 8886; Metazoa - 193; Fungi - 474; Plants - 279; Viruses - 0; Other Eukaryotes - 6560 (source: NCBI BLink). & (q39891|leu1_soybn : 622.0) Probable 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase) (Late nodulin 56) (N-56) - Glycine max (Soybean) & (reliability: 1524.0) & (original description: no original description)


Gene families : OG_42_0001355 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001355_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Klebsormidium release: Kfl00272_0030
Cluster HCCA clusters: Cluster_64

Target Alias Description ECC score Gene Family Method Actions
173046 No alias methylthioalkylmalate synthase-like 4 0.02 Orthogroups_2024-Update
413264 No alias 2-isopropylmalate synthase 1 0.03 Orthogroups_2024-Update
A4A49_09209 No alias 2-isopropylmalate synthase a 0.03 Orthogroups_2024-Update
Brara.F01305.1 No alias 2-isopropylmalate synthase *(IPMS) & EC_2.3 acyltransferase 0.02 Orthogroups_2024-Update
Glyma.10G295400 No alias 2-isopropylmalate synthase 1 0.03 Orthogroups_2024-Update
Seita.8G026900.1 No alias 2-isopropylmalate synthase *(IPMS) & EC_2.3 acyltransferase 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source
MF GO:0003824 catalytic activity IEA InterProScan predictions
MF GO:0003852 2-isopropylmalate synthase activity IEA InterProScan predictions
BP GO:0009098 leucine biosynthetic process IEA InterProScan predictions
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Type GO Term Name Evidence Source
MF GO:0000062 fatty-acyl-CoA binding IEP Predicted GO
MF GO:0000166 nucleotide binding IEP Predicted GO
BP GO:0000271 polysaccharide biosynthetic process IEP Predicted GO
MF GO:0003989 acetyl-CoA carboxylase activity IEP Predicted GO
MF GO:0004743 pyruvate kinase activity IEP Predicted GO
MF GO:0005488 binding IEP Predicted GO
MF GO:0005524 ATP binding IEP Predicted GO
BP GO:0006073 cellular glucan metabolic process IEP Predicted GO
BP GO:0006753 nucleoside phosphate metabolic process IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0006814 sodium ion transport IEP Predicted GO
MF GO:0008144 drug binding IEP Predicted GO
MF GO:0008252 nucleotidase activity IEP Predicted GO
MF GO:0008253 5'-nucleotidase activity IEP Predicted GO
MF GO:0008658 penicillin binding IEP Predicted GO
BP GO:0009056 catabolic process IEP Predicted GO
BP GO:0009117 nucleotide metabolic process IEP Predicted GO
BP GO:0009166 nucleotide catabolic process IEP Predicted GO
BP GO:0009250 glucan biosynthetic process IEP Predicted GO
BP GO:0009262 deoxyribonucleotide metabolic process IEP Predicted GO
BP GO:0009264 deoxyribonucleotide catabolic process IEP Predicted GO
BP GO:0016310 phosphorylation IEP Predicted GO
MF GO:0016421 CoA carboxylase activity IEP Predicted GO
MF GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEP Predicted GO
MF GO:0016759 cellulose synthase activity IEP Predicted GO
MF GO:0016760 cellulose synthase (UDP-forming) activity IEP Predicted GO
MF GO:0016791 phosphatase activity IEP Predicted GO
MF GO:0016885 ligase activity, forming carbon-carbon bonds IEP Predicted GO
MF GO:0017076 purine nucleotide binding IEP Predicted GO
BP GO:0019439 aromatic compound catabolic process IEP Predicted GO
BP GO:0019637 organophosphate metabolic process IEP Predicted GO
BP GO:0030243 cellulose metabolic process IEP Predicted GO
BP GO:0030244 cellulose biosynthetic process IEP Predicted GO
MF GO:0030554 adenyl nucleotide binding IEP Predicted GO
MF GO:0030955 potassium ion binding IEP Predicted GO
MF GO:0031406 carboxylic acid binding IEP Predicted GO
MF GO:0031420 alkali metal ion binding IEP Predicted GO
MF GO:0032553 ribonucleotide binding IEP Predicted GO
MF GO:0032555 purine ribonucleotide binding IEP Predicted GO
MF GO:0032559 adenyl ribonucleotide binding IEP Predicted GO
BP GO:0032787 monocarboxylic acid metabolic process IEP Predicted GO
MF GO:0033218 amide binding IEP Predicted GO
MF GO:0033293 monocarboxylic acid binding IEP Predicted GO
BP GO:0033692 cellular polysaccharide biosynthetic process IEP Predicted GO
MF GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity IEP Predicted GO
BP GO:0034404 nucleobase-containing small molecule biosynthetic process IEP Predicted GO
BP GO:0034655 nucleobase-containing compound catabolic process IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
MF GO:0036094 small molecule binding IEP Predicted GO
MF GO:0043167 ion binding IEP Predicted GO
MF GO:0043168 anion binding IEP Predicted GO
MF GO:0043177 organic acid binding IEP Predicted GO
BP GO:0044042 glucan metabolic process IEP Predicted GO
BP GO:0044248 cellular catabolic process IEP Predicted GO
BP GO:0044264 cellular polysaccharide metabolic process IEP Predicted GO
BP GO:0044270 cellular nitrogen compound catabolic process IEP Predicted GO
BP GO:0046434 organophosphate catabolic process IEP Predicted GO
BP GO:0046700 heterocycle catabolic process IEP Predicted GO
BP GO:0051180 vitamin transport IEP Predicted GO
BP GO:0051273 beta-glucan metabolic process IEP Predicted GO
BP GO:0051274 beta-glucan biosynthetic process IEP Predicted GO
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Predicted GO
BP GO:0072330 monocarboxylic acid biosynthetic process IEP Predicted GO
MF GO:0090482 vitamin transmembrane transporter activity IEP Predicted GO
MF GO:0097159 organic cyclic compound binding IEP Predicted GO
MF GO:0097367 carbohydrate derivative binding IEP Predicted GO
BP GO:1901135 carbohydrate derivative metabolic process IEP Predicted GO
BP GO:1901136 carbohydrate derivative catabolic process IEP Predicted GO
MF GO:1901265 nucleoside phosphate binding IEP Predicted GO
BP GO:1901292 nucleoside phosphate catabolic process IEP Predicted GO
BP GO:1901361 organic cyclic compound catabolic process IEP Predicted GO
MF GO:1901363 heterocyclic compound binding IEP Predicted GO
MF GO:1901567 fatty acid derivative binding IEP Predicted GO
BP GO:1901575 organic substance catabolic process IEP Predicted GO
MF GO:1901681 sulfur compound binding IEP Predicted GO
InterPro domains Description Start Stop
IPR000891 PYR_CT 117 396
IPR013709 2-isopropylmalate_synth_dimer 496 641
No external refs found!