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- Kfl00280_0170
Kfl00280_0170 (kfl00280_0170_v1.1,...)
Aliases : kfl00280_0170_v1.1, kfl00280_0170_v1.1
Description : "(at3g44200 : 388.0) Encodes AtNek5, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.Interacts physically with plant kinesins ARK1 and ARK2. Mutants show defects in root epidermal cell morphology, trichome branching and other epidermal cell abnormalities suggesting a rol e in epidermal cell differentiation. NEK6 co-localizes with cortical microtubules.; ""NIMA (never in mitosis, gene A)-related 6"" (NEK6); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: microtubule-based process, epidermal cell differentiation; LOCATED IN: cortical microtubule; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related serine/threonine kinase 1 (TAIR:AT1G54510.3); Has 127749 Blast hits to 124714 proteins in 4408 species: Archae - 106; Bacteria - 14910; Metazoa - 47444; Fungi - 12949; Plants - 30417; Viruses - 519; Other Eukaryotes - 21404 (source: NCBI BLink). & (q5qn75|m2k1_orysa : 138.0) Mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK1) (OsMEK1) - Oryza sativa (Rice) & (reliability: 714.0) & (original description: no original description)"
Expression Profile
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Klebsormidium release: Kfl00280_0170 | |
| Cluster | HCCA clusters: Cluster_94 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| Brara.C03074.1 | No alias | NEK protein kinase & EC_2.7 transferase transferring... | 0.03 | Orthogroups_2024-Update | |
| MA_127019g0010 | No alias | "(at3g44200 : 469.0) Encodes AtNek5, a member of the... | 0.02 | Orthogroups_2024-Update | |
| Potri.003G205400 | No alias | NIMA-related kinase 5 | 0.02 | Orthogroups_2024-Update | |
| Seita.1G214200.1 | No alias | NEK protein kinase & EC_2.7 transferase transferring... | 0.02 | Orthogroups_2024-Update | |
| Seita.3G226000.1 | No alias | NEK protein kinase & EC_2.7 transferase transferring... | 0.03 | Orthogroups_2024-Update | |
| Solyc11g071980 | No alias | No description available | 0.02 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | None | Extended |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0004672 | protein kinase activity | IEA | InterProScan predictions |
| MF | GO:0005488 | binding | None | Extended |
| MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
| BP | GO:0006464 | cellular protein modification process | None | Extended |
| BP | GO:0006468 | protein phosphorylation | IEA | InterProScan predictions |
| BP | GO:0006793 | phosphorus metabolic process | None | Extended |
| BP | GO:0006796 | phosphate-containing compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| MF | GO:0008144 | drug binding | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0016301 | kinase activity | None | Extended |
| BP | GO:0016310 | phosphorylation | None | Extended |
| MF | GO:0016740 | transferase activity | None | Extended |
| MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | None | Extended |
| MF | GO:0016773 | phosphotransferase activity, alcohol group as acceptor | None | Extended |
| MF | GO:0017076 | purine nucleotide binding | None | Extended |
| BP | GO:0019538 | protein metabolic process | None | Extended |
| MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
| MF | GO:0032553 | ribonucleotide binding | None | Extended |
| MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
| MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
| MF | GO:0036094 | small molecule binding | None | Extended |
| BP | GO:0036211 | protein modification process | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043168 | anion binding | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| BP | GO:0043412 | macromolecule modification | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| BP | GO:0044267 | cellular protein metabolic process | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
| MF | GO:0140096 | catalytic activity, acting on a protein | None | Extended |
| MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| BP | GO:1901564 | organonitrogen compound metabolic process | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0004329 | formate-tetrahydrofolate ligase activity | IEP | Predicted GO |
| MF | GO:0004619 | phosphoglycerate mutase activity | IEP | Predicted GO |
| CC | GO:0005575 | cellular_component | IEP | Predicted GO |
| BP | GO:0005996 | monosaccharide metabolic process | IEP | Predicted GO |
| BP | GO:0006006 | glucose metabolic process | IEP | Predicted GO |
| BP | GO:0006007 | glucose catabolic process | IEP | Predicted GO |
| BP | GO:0006801 | superoxide metabolic process | IEP | Predicted GO |
| BP | GO:0006820 | anion transport | IEP | Predicted GO |
| MF | GO:0008483 | transaminase activity | IEP | Predicted GO |
| MF | GO:0008509 | anion transmembrane transporter activity | IEP | Predicted GO |
| MF | GO:0015098 | molybdate ion transmembrane transporter activity | IEP | Predicted GO |
| MF | GO:0015103 | inorganic anion transmembrane transporter activity | IEP | Predicted GO |
| BP | GO:0015689 | molybdate ion transport | IEP | Predicted GO |
| BP | GO:0015698 | inorganic anion transport | IEP | Predicted GO |
| BP | GO:0016052 | carbohydrate catabolic process | IEP | Predicted GO |
| MF | GO:0016769 | transferase activity, transferring nitrogenous groups | IEP | Predicted GO |
| MF | GO:0016866 | intramolecular transferase activity | IEP | Predicted GO |
| MF | GO:0016868 | intramolecular transferase activity, phosphotransferases | IEP | Predicted GO |
| MF | GO:0016879 | ligase activity, forming carbon-nitrogen bonds | IEP | Predicted GO |
| BP | GO:0019318 | hexose metabolic process | IEP | Predicted GO |
| BP | GO:0019320 | hexose catabolic process | IEP | Predicted GO |
| MF | GO:0030145 | manganese ion binding | IEP | Predicted GO |
| MF | GO:0030170 | pyridoxal phosphate binding | IEP | Predicted GO |
| BP | GO:0044282 | small molecule catabolic process | IEP | Predicted GO |
| BP | GO:0046365 | monosaccharide catabolic process | IEP | Predicted GO |
| MF | GO:0046983 | protein dimerization activity | IEP | Predicted GO |
| MF | GO:0070279 | vitamin B6 binding | IEP | Predicted GO |
| BP | GO:0072593 | reactive oxygen species metabolic process | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR000938 | CAP-Gly_domain | 1193 | 1257 |
| IPR000719 | Prot_kinase_dom | 22 | 276 |
