Kfl00299_0060 (kfl00299_0060_v1.1)

Aliases : kfl00299_0060_v1.1

Description : (p37221|maom_soltu : 666.0) NAD-dependent malic enzyme 62 kDa isoform, mitochondrial precursor (EC 1.1.1.39) (NAD-ME) - Solanum tuberosum (Potato) & (at2g13560 : 653.0) Encodes an NAD-dependent malic enzyme (NAD-ME) that does not act on oxaloacetate, indicating that it belongs to EC 1.1.1.39. It is a member of the alpha family of NAD-MEs in plants. It appears to function as a homodimer or as a heterodimer with the beta-type NAD-ME2 (At4g00570). NAD-ME1 transcript and protein levels are higher during the night than during the day.; NAD-dependent malic enzyme 1 (NAD-ME1); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress, malate metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD-dependent malic enzyme 2 (TAIR:AT4G00570.1); Has 9465 Blast hits to 9448 proteins in 2440 species: Archae - 143; Bacteria - 6328; Metazoa - 607; Fungi - 221; Plants - 457; Viruses - 0; Other Eukaryotes - 1709 (source: NCBI BLink). & (reliability: 1306.0) & (original description: no original description)

Gene families : OG_42_0002866 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002866_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Klebsormidium release: Kfl00299_0060
Cluster	HCCA clusters: Cluster_55

Target	Alias	Description	ECC score	Gene Family Method	Actions
At2g13560	No alias	NAD-dependent malic enzyme 1, mitochondrial...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004470	malic enzyme activity	None	Extended
MF	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016615	malate dehydrogenase activity	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	None	Extended
MF	GO:0051287	NAD binding	IEA	InterProScan predictions
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0002161	aminoacyl-tRNA editing activity	IEP	Predicted GO
MF	GO:0004518	nuclease activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0004832	valine-tRNA ligase activity	IEP	Predicted GO
CC	GO:0005737	cytoplasm	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006891	intra-Golgi vesicle-mediated transport	IEP	Predicted GO
BP	GO:0007186	G protein-coupled receptor signaling pathway	IEP	Predicted GO
BP	GO:0016070	RNA metabolic process	IEP	Predicted GO
MF	GO:0016788	hydrolase activity, acting on ester bonds	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
CC	GO:0017119	Golgi transport complex	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0031683	G-protein beta/gamma-subunit complex binding	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
MF	GO:0044877	protein-containing complex binding	IEP	Predicted GO
MF	GO:0051499	D-aminoacyl-tRNA deacylase activity	IEP	Predicted GO
MF	GO:0052689	carboxylic ester hydrolase activity	IEP	Predicted GO
CC	GO:0099023	tethering complex	IEP	Predicted GO
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR012302	Malic_NAD-bd	261	524
IPR012301	Malic_N_dom	71	251

External Links

No external refs found!

Kfl00299_0060 (kfl00299_0060_v1.1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation