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Kfl00608_0080 (kfl00608_0080_v1.1)


Aliases : kfl00608_0080_v1.1

Description : (at1g68760 : 137.0) Encodes a cytosol-localized nudix hydrolase that hydrolyzes 8-oxo-(d)GTP to its monophosphate form. This protective mechanism prevents the misincorporation of these oxidized nucleotides into DNA and RNA. NUDX1 also has a low level of dihydroneopterin triphosphate pyrophosphatase activity in vitro and may participate in the folate synthesis pathway.; nudix hydrolase 1 (NUDX1); FUNCTIONS IN: hydrolase activity, dihydroneopterin triphosphate pyrophosphohydrolase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; INVOLVED IN: response to DNA damage stimulus; LOCATED IN: cytosol; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase (InterPro:IPR020476), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 6319 Blast hits to 6317 proteins in 1575 species: Archae - 191; Bacteria - 5327; Metazoa - 193; Fungi - 66; Plants - 51; Viruses - 14; Other Eukaryotes - 477 (source: NCBI BLink). & (reliability: 274.0) & (original description: no original description)


Gene families : OG_42_0008511 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0008511_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Klebsormidium release: Kfl00608_0080
Cluster HCCA clusters: Cluster_58

Target Alias Description ECC score Gene Family Method Actions
A4A49_36818 No alias nudix hydrolase 1 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source
MF GO:0016787 hydrolase activity IEA InterProScan predictions
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Type GO Term Name Evidence Source
CC GO:0005783 endoplasmic reticulum IEP Predicted GO
BP GO:0006511 ubiquitin-dependent protein catabolic process IEP Predicted GO
BP GO:0006790 sulfur compound metabolic process IEP Predicted GO
MF GO:0008199 ferric iron binding IEP Predicted GO
BP GO:0016226 iron-sulfur cluster assembly IEP Predicted GO
BP GO:0019941 modification-dependent protein catabolic process IEP Predicted GO
BP GO:0031163 metallo-sulfur cluster assembly IEP Predicted GO
BP GO:0043632 modification-dependent macromolecule catabolic process IEP Predicted GO
InterPro domains Description Start Stop
IPR000086 NUDIX_hydrolase_dom 13 128
No external refs found!