MA_10090g0010

Description : (q42699|mete_catro : 1086.0) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Vitamin-B12-independent methionine synthase isozyme) (Cobalamin-independent methionine synthase isozyme) - Catharanthus roseus (Rosy periwinkle) (Madag & (at5g17920 : 908.0) Encodes a cytosolic cobalamin-independent methionine synthase, involved in methionine regeneration via the activated methyl cycle (SAM cycle). The protein undergoes thiolation following treatment with the oxidant tert-butylhydroperoxide.; COBALAMIN-INDEPENDENT METHIONINE SYNTHASE (ATCIMS); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to zinc ion, response to salt stress, methionine biosynthetic process; LOCATED IN: in 6 components; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: methionine synthase 2 (TAIR:AT3G03780.3); Has 4442 Blast hits to 4434 proteins in 1682 species: Archae - 183; Bacteria - 3246; Metazoa - 14; Fungi - 206; Plants - 251; Viruses - 2; Other Eukaryotes - 540 (source: NCBI BLink). & (reliability: 1684.0) & (original description: no original description)

Gene families : OG_42_0002037 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002037_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_10090g0010
Cluster	HCCA clusters: Cluster_243

Target	Alias	Description	ECC score	Gene Family Method
Bradi1g13290	No alias	Cobalamin-independent synthase family protein	0.03	Orthogroups_2024-Update
Bradi4g01200	No alias	Cobalamin-independent synthase family protein	0.02	Orthogroups_2024-Update
Cre03.g180750	No alias	methionine synthase 3	0.03	Orthogroups_2024-Update
GRMZM2G112149	No alias	Cobalamin-independent synthase family protein	0.03	Orthogroups_2024-Update
GRMZM2G165747	No alias	Cobalamin-independent synthase family protein	0.03	Orthogroups_2024-Update
PSME_00023768-RA	No alias	(at5g17920 : 1243.0) Encodes a cytosolic...	0.03	Orthogroups_2024-Update
Pp1s33_110V6	No alias	vitamin-b12 independent methionine...	0.03	Orthogroups_2024-Update
Pp1s399_19V6	No alias	vitamin-b12 independent methionine...	0.02	Orthogroups_2024-Update
Seita.3G035500.1	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	None	Extended
BP	GO:0000097	sulfur amino acid biosynthetic process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006555	methionine metabolic process	None	Extended
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
MF	GO:0008172	S-methyltransferase activity	None	Extended
MF	GO:0008270	zinc ion binding	IEA	InterProScan predictions
BP	GO:0008652	cellular amino acid biosynthetic process	IEA	InterProScan predictions
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009066	aspartate family amino acid metabolic process	None	Extended
BP	GO:0009067	aspartate family amino acid biosynthetic process	None	Extended
BP	GO:0009086	methionine biosynthetic process	IEA	InterProScan predictions
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044272	sulfur compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901605	alpha-amino acid metabolic process	None	Extended
BP	GO:1901607	alpha-amino acid biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003678	DNA helicase activity	IEP	Predicted GO
MF	GO:0003684	damaged DNA binding	IEP	Predicted GO
MF	GO:0004332	fructose-bisphosphate aldolase activity	IEP	Predicted GO
MF	GO:0004427	inorganic diphosphatase activity	IEP	Predicted GO
MF	GO:0004455	ketol-acid reductoisomerase activity	IEP	Predicted GO
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
BP	GO:0006081	cellular aldehyde metabolic process	IEP	Predicted GO
BP	GO:0006098	pentose-phosphate shunt	IEP	Predicted GO
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006289	nucleotide-excision repair	IEP	Predicted GO
BP	GO:0006606	protein import into nucleus	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006739	NADP metabolic process	IEP	Predicted GO
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Predicted GO
BP	GO:0006810	transport	IEP	Predicted GO
BP	GO:0006886	intracellular protein transport	IEP	Predicted GO
BP	GO:0006913	nucleocytoplasmic transport	IEP	Predicted GO
BP	GO:0008104	protein localization	IEP	Predicted GO
BP	GO:0009081	branched-chain amino acid metabolic process	IEP	Predicted GO
BP	GO:0009082	branched-chain amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009117	nucleotide metabolic process	IEP	Predicted GO
MF	GO:0009678	hydrogen-translocating pyrophosphatase activity	IEP	Predicted GO
BP	GO:0010498	proteasomal protein catabolic process	IEP	Predicted GO
BP	GO:0015031	protein transport	IEP	Predicted GO
MF	GO:0015298	solute:cation antiporter activity	IEP	Predicted GO
MF	GO:0015299	solute:proton antiporter activity	IEP	Predicted GO
BP	GO:0015833	peptide transport	IEP	Predicted GO
CC	GO:0016021	integral component of membrane	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016746	transferase activity, transferring acyl groups	IEP	Predicted GO
MF	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	IEP	Predicted GO
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Predicted GO
MF	GO:0016832	aldehyde-lyase activity	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019682	glyceraldehyde-3-phosphate metabolic process	IEP	Predicted GO
BP	GO:0019693	ribose phosphate metabolic process	IEP	Predicted GO
MF	GO:0022857	transmembrane transporter activity	IEP	Predicted GO
CC	GO:0030117	membrane coat	IEP	Predicted GO
CC	GO:0030118	clathrin coat	IEP	Predicted GO
CC	GO:0030120	vesicle coat	IEP	Predicted GO
CC	GO:0030125	clathrin vesicle coat	IEP	Predicted GO
CC	GO:0030130	clathrin coat of trans-Golgi network vesicle	IEP	Predicted GO
CC	GO:0030132	clathrin coat of coated pit	IEP	Predicted GO
BP	GO:0030163	protein catabolic process	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
CC	GO:0031224	intrinsic component of membrane	IEP	Predicted GO
BP	GO:0033036	macromolecule localization	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0034504	protein localization to nucleus	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0042886	amide transport	IEP	Predicted GO
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
CC	GO:0044431	Golgi apparatus part	IEP	Predicted GO
CC	GO:0044433	cytoplasmic vesicle part	IEP	Predicted GO
CC	GO:0044459	plasma membrane part	IEP	Predicted GO
BP	GO:0045184	establishment of protein localization	IEP	Predicted GO
BP	GO:0046483	heterocycle metabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046907	intracellular transport	IEP	Predicted GO
MF	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Predicted GO
BP	GO:0051169	nuclear transport	IEP	Predicted GO
BP	GO:0051170	import into nucleus	IEP	Predicted GO
BP	GO:0051179	localization	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051234	establishment of localization	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0051641	cellular localization	IEP	Predicted GO
BP	GO:0051649	establishment of localization in cell	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Predicted GO
MF	GO:0061608	nuclear import signal receptor activity	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0071702	organic substance transport	IEP	Predicted GO
BP	GO:0071705	nitrogen compound transport	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
CC	GO:0098797	plasma membrane protein complex	IEP	Predicted GO
MF	GO:0140104	molecular carrier activity	IEP	Predicted GO
MF	GO:0140142	nucleocytoplasmic carrier activity	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002629	Met_Synth_C/arc	545	681
IPR002629	Met_Synth_C/arc	433	543
IPR013215	Cbl-indep_Met_Synth_N	3	317

External Links

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MA_10090g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation