MA_10434957g0010

Description : (at2g36910 : 575.0) Belongs to the family of ATP-binding cassette (ABC) transporters. Also known as AtMDR1.Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Exerts nonredundant, partially overlapping functions with the ABC transporter encoded by AT3G28860. PGP1 mediates cellular efflux of IAA and interacts with PIN genes that may confer an accelerated vectoral component to PGP-mediated transport. The non-polar localization of PGP1 at root and shoot apices, where IAA gradient-driven transport is impaired, may be required to confer directionality to auxin transport in those tissues.; ATP binding cassette subfamily B1 (ABCB1); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, calmodulin binding, auxin efflux transmembrane transporter activity; INVOLVED IN: in 10 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B19 (TAIR:AT3G28860.1); Has 825599 Blast hits to 386427 proteins in 4134 species: Archae - 14573; Bacteria - 644325; Metazoa - 17752; Fungi - 12077; Plants - 9020; Viruses - 35; Other Eukaryotes - 127817 (source: NCBI BLink). & (q6yuu5|mdr_orysa : 378.0) Putative multidrug resistance protein (P-glycoprotein) - Oryza sativa (Rice) & (reliability: 1150.0) & (original description: no original description)

Gene families : OG_42_0000040 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000040_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_10434957g0010
Cluster	HCCA clusters: Cluster_1

Target	Alias	Description	ECC score	Gene Family Method
At5g46540	No alias	ABC transporter B family member 7...	0.02	Orthogroups_2024-Update
GRMZM2G085111	No alias	P-glycoprotein 21	0.03	Orthogroups_2024-Update
GRMZM2G111462	No alias	ABC transporter family protein	0.02	Orthogroups_2024-Update
Glyma.13G118500	No alias	P-glycoprotein 11	0.02	Orthogroups_2024-Update
Mp2g02910.1	No alias	auxin efflux transporter (ABCB19). subfamily ABCB transporter	0.02	Orthogroups_2024-Update
Mp2g11920.1	No alias	subfamily ABCB transporter	0.02	Orthogroups_2024-Update
Potri.002G019600	No alias	P-glycoprotein 13	0.03	Orthogroups_2024-Update
Potri.002G187500	No alias	ATP binding cassette subfamily B4	0.03	Orthogroups_2024-Update
Seita.1G280600.1	No alias	subfamily ABCB transporter	0.03	Orthogroups_2024-Update
Sopen02g032160	No alias	ABC transporter transmembrane region	0.02	Orthogroups_2024-Update
evm.model.tig00020952.7	No alias	(at4g25960 : 162.0) P-glycoprotein 2 (PGP2); FUNCTIONS...	0.01	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005215	transporter activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0006810	transport	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
MF	GO:0015399	primary active transmembrane transporter activity	None	Extended
MF	GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	None	Extended
CC	GO:0016021	integral component of membrane	IEA	InterProScan predictions
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IEA	InterProScan predictions
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0022804	active transmembrane transporter activity	None	Extended
MF	GO:0022857	transmembrane transporter activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA	InterProScan predictions
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0043492	ATPase activity, coupled to movement of substances	None	Extended
CC	GO:0044425	membrane part	None	Extended
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended
BP	GO:0055085	transmembrane transport	IEA	InterProScan predictions
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004664	prephenate dehydratase activity	IEP	Predicted GO
CC	GO:0005694	chromosome	IEP	Predicted GO
CC	GO:0005875	microtubule associated complex	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006558	L-phenylalanine metabolic process	IEP	Predicted GO
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006787	porphyrin-containing compound catabolic process	IEP	Predicted GO
MF	GO:0008373	sialyltransferase activity	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	Predicted GO
BP	GO:0009073	aromatic amino acid family biosynthetic process	IEP	Predicted GO
BP	GO:0009094	L-phenylalanine biosynthetic process	IEP	Predicted GO
BP	GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway	IEP	Predicted GO
CC	GO:0009523	photosystem II	IEP	Predicted GO
CC	GO:0009654	photosystem II oxygen evolving complex	IEP	Predicted GO
BP	GO:0010109	regulation of photosynthesis	IEP	Predicted GO
BP	GO:0010207	photosystem II assembly	IEP	Predicted GO
MF	GO:0010242	oxygen evolving activity	IEP	Predicted GO
BP	GO:0015994	chlorophyll metabolic process	IEP	Predicted GO
BP	GO:0015996	chlorophyll catabolic process	IEP	Predicted GO
BP	GO:0016053	organic acid biosynthetic process	IEP	Predicted GO
MF	GO:0016835	carbon-oxygen lyase activity	IEP	Predicted GO
MF	GO:0016836	hydro-lyase activity	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
CC	GO:0030286	dynein complex	IEP	Predicted GO
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Predicted GO
BP	GO:0033015	tetrapyrrole catabolic process	IEP	Predicted GO
BP	GO:0042440	pigment metabolic process	IEP	Predicted GO
BP	GO:0042548	regulation of photosynthesis, light reaction	IEP	Predicted GO
BP	GO:0042549	photosystem II stabilization	IEP	Predicted GO
BP	GO:0043467	regulation of generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0043933	protein-containing complex subunit organization	IEP	Predicted GO
CC	GO:0044430	cytoskeletal part	IEP	Predicted GO
CC	GO:0044436	thylakoid part	IEP	Predicted GO
BP	GO:0046149	pigment catabolic process	IEP	Predicted GO
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Predicted GO
MF	GO:0047746	chlorophyllase activity	IEP	Predicted GO
BP	GO:0051187	cofactor catabolic process	IEP	Predicted GO
BP	GO:0051259	protein complex oligomerization	IEP	Predicted GO
BP	GO:0051260	protein homooligomerization	IEP	Predicted GO
BP	GO:0065003	protein-containing complex assembly	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
BP	GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	IEP	Predicted GO
BP	GO:1902223	erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
CC	GO:1990204	oxidoreductase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR011527	ABC1_TM_dom	12	108
IPR003439	ABC_transporter-like	179	330

External Links

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MA_10434957g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation