MA_134292g0010

Description : (at3g06860 : 971.0) Encodes a multifunctional protein. Involved in peroxisomal fatty acid beta oxidation. Loss-of-function mutant lacks hydroxyacyl-CoA dehydrogenase activity and have reduced levels of long-chain enoyl-CoA hydratase activity. The mutant has fewer but larger peroxisomes.; multifunctional protein 2 (MFP2); FUNCTIONS IN: enoyl-CoA hydratase activity, 3-hydroxyacyl-CoA dehydrogenase activity; INVOLVED IN: fatty acid beta-oxidation; LOCATED IN: nucleolus, cell wall, peroxisome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Enoyl-CoA hydratase/isomerase, conserved site (InterPro:IPR018376), 3-hydroxyacyl-CoA dehydrogenase, conserved site (InterPro:IPR006180), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), 3-hydroxyacyl-CoA dehydrogenase, NAD binding (InterPro:IPR006176), Crotonase, core (InterPro:IPR001753), 3-hydroxyacyl-CoA dehydrogenase, C-terminal (InterPro:IPR006108); BEST Arabidopsis thaliana protein match is: Enoyl-CoA hydratase/isomerase family (TAIR:AT4G29010.1); Has 46309 Blast hits to 45272 proteins in 2450 species: Archae - 810; Bacteria - 29664; Metazoa - 2011; Fungi - 1039; Plants - 666; Viruses - 0; Other Eukaryotes - 12119 (source: NCBI BLink). & (o49809|mfpa_brana : 968.0) Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3-2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase ( & (reliability: 1942.0) & (original description: no original description)

Gene families : OG_42_0001149 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001149_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_134292g0010
Cluster	HCCA clusters: Cluster_151

Target	Alias	Description	ECC score	Gene Family Method
Bradi3g10180	No alias	Enoyl-CoA hydratase/isomerase family	0.02	Orthogroups_2024-Update
Bradi4g28310	No alias	multifunctional protein 2	0.04	Orthogroups_2024-Update
Glyma.07G246300	No alias	multifunctional protein 2	0.03	Orthogroups_2024-Update
Glyma.09G191700	No alias	Enoyl-CoA hydratase/isomerase family	0.04	Orthogroups_2024-Update
HORVU6Hr1G021980.6	No alias	Unknown function	0.02	Orthogroups_2024-Update
Kfl00759_0070	kfl00759_0070_v1.1	(o49809\|mfpa_brana : 851.0) Glyoxysomal fatty acid...	0.01	Orthogroups_2024-Update
PSME_00011156-RA	No alias	(at3g06860 : 1007.0) Encodes a multifunctional protein....	0.04	Orthogroups_2024-Update
Pp1s75_175V6	No alias	peroxisomal fatty acid beta-oxidation multifunctional protein	0.03	Orthogroups_2024-Update
Sobic.004G124200.1	No alias	multifunctional enzyme *(MFP)	0.02	Orthogroups_2024-Update
Sopen06g003930	No alias	Enoyl-CoA hydratase/isomerase family	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	IEA	InterProScan predictions
MF	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	IEA	InterProScan predictions
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006631	fatty acid metabolic process	IEA	InterProScan predictions
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	IEA	InterProScan predictions
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0032787	monocarboxylic acid metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000502	proteasome complex	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003872	6-phosphofructokinase activity	IEP	Predicted GO
MF	GO:0003997	acyl-CoA oxidase activity	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004190	aspartic-type endopeptidase activity	IEP	Predicted GO
MF	GO:0004298	threonine-type endopeptidase activity	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
CC	GO:0005777	peroxisome	IEP	Predicted GO
CC	GO:0005839	proteasome core complex	IEP	Predicted GO
CC	GO:0005852	eukaryotic translation initiation factor 3 complex	IEP	Predicted GO
BP	GO:0006606	protein import into nucleus	IEP	Predicted GO
BP	GO:0006635	fatty acid beta-oxidation	IEP	Predicted GO
BP	GO:0006886	intracellular protein transport	IEP	Predicted GO
BP	GO:0006904	vesicle docking involved in exocytosis	IEP	Predicted GO
BP	GO:0006913	nucleocytoplasmic transport	IEP	Predicted GO
BP	GO:0008104	protein localization	IEP	Predicted GO
MF	GO:0008443	phosphofructokinase activity	IEP	Predicted GO
MF	GO:0008536	Ran GTPase binding	IEP	Predicted GO
MF	GO:0008641	ubiquitin-like modifier activating enzyme activity	IEP	Predicted GO
BP	GO:0009056	catabolic process	IEP	Predicted GO
BP	GO:0009062	fatty acid catabolic process	IEP	Predicted GO
BP	GO:0009894	regulation of catabolic process	IEP	Predicted GO
BP	GO:0015031	protein transport	IEP	Predicted GO
BP	GO:0015833	peptide transport	IEP	Predicted GO
BP	GO:0016042	lipid catabolic process	IEP	Predicted GO
BP	GO:0016054	organic acid catabolic process	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
MF	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	IEP	Predicted GO
MF	GO:0016877	ligase activity, forming carbon-sulfur bonds	IEP	Predicted GO
MF	GO:0017016	Ras GTPase binding	IEP	Predicted GO
BP	GO:0017038	protein import	IEP	Predicted GO
MF	GO:0019200	carbohydrate kinase activity	IEP	Predicted GO
BP	GO:0019395	fatty acid oxidation	IEP	Predicted GO
CC	GO:0019773	proteasome core complex, alpha-subunit complex	IEP	Predicted GO
MF	GO:0019899	enzyme binding	IEP	Predicted GO
BP	GO:0022406	membrane docking	IEP	Predicted GO
CC	GO:0030120	vesicle coat	IEP	Predicted GO
CC	GO:0030126	COPI vesicle coat	IEP	Predicted GO
BP	GO:0030258	lipid modification	IEP	Predicted GO
MF	GO:0031267	small GTPase binding	IEP	Predicted GO
MF	GO:0031369	translation initiation factor binding	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
BP	GO:0033036	macromolecule localization	IEP	Predicted GO
BP	GO:0033365	protein localization to organelle	IEP	Predicted GO
BP	GO:0034440	lipid oxidation	IEP	Predicted GO
BP	GO:0034504	protein localization to nucleus	IEP	Predicted GO
BP	GO:0034613	cellular protein localization	IEP	Predicted GO
BP	GO:0042176	regulation of protein catabolic process	IEP	Predicted GO
CC	GO:0042579	microbody	IEP	Predicted GO
BP	GO:0042886	amide transport	IEP	Predicted GO
BP	GO:0044242	cellular lipid catabolic process	IEP	Predicted GO
BP	GO:0044248	cellular catabolic process	IEP	Predicted GO
BP	GO:0044282	small molecule catabolic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044431	Golgi apparatus part	IEP	Predicted GO
CC	GO:0044433	cytoplasmic vesicle part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
BP	GO:0045184	establishment of protein localization	IEP	Predicted GO
BP	GO:0046395	carboxylic acid catabolic process	IEP	Predicted GO
BP	GO:0046907	intracellular transport	IEP	Predicted GO
BP	GO:0048278	vesicle docking	IEP	Predicted GO
MF	GO:0051020	GTPase binding	IEP	Predicted GO
BP	GO:0051169	nuclear transport	IEP	Predicted GO
BP	GO:0051170	import into nucleus	IEP	Predicted GO
BP	GO:0051179	localization	IEP	Predicted GO
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Predicted GO
BP	GO:0051640	organelle localization	IEP	Predicted GO
BP	GO:0051641	cellular localization	IEP	Predicted GO
BP	GO:0051649	establishment of localization in cell	IEP	Predicted GO
MF	GO:0061608	nuclear import signal receptor activity	IEP	Predicted GO
MF	GO:0070001	aspartic-type peptidase activity	IEP	Predicted GO
MF	GO:0070003	threonine-type peptidase activity	IEP	Predicted GO
BP	GO:0070727	cellular macromolecule localization	IEP	Predicted GO
BP	GO:0071702	organic substance transport	IEP	Predicted GO
BP	GO:0071705	nitrogen compound transport	IEP	Predicted GO
BP	GO:0072329	monocarboxylic acid catabolic process	IEP	Predicted GO
BP	GO:0072594	establishment of protein localization to organelle	IEP	Predicted GO
BP	GO:0140029	exocytic process	IEP	Predicted GO
BP	GO:0140056	organelle localization by membrane tethering	IEP	Predicted GO
MF	GO:0140104	molecular carrier activity	IEP	Predicted GO
MF	GO:0140142	nucleocytoplasmic carrier activity	IEP	Predicted GO
BP	GO:1901575	organic substance catabolic process	IEP	Predicted GO
CC	GO:1905368	peptidase complex	IEP	Predicted GO
CC	GO:1905369	endopeptidase complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006176	3-OHacyl-CoA_DH_NAD-bd	299	477
IPR001753	Enoyl-CoA_hydra/iso	30	194
IPR006108	3HC_DH_C	612	696
IPR006108	3HC_DH_C	480	573

External Links

No external refs found!

MA_134292g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation