MA_16234g0010

Description : (o64966|hmdh1_goshi : 475.0) 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (EC 1.1.1.34) (HMG-CoA reductase 1) - Gossypium hirsutum (Upland cotton) & (at1g76490 : 459.0) Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine; hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink). & (reliability: 918.0) & (original description: no original description)

Gene families : OG_42_0001334 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001334_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_16234g0010
Cluster	HCCA clusters: Cluster_282

Target	Alias	Description	ECC score	Gene Family Method
Glyma.11G088000	No alias	hydroxy methylglutaryl CoA reductase 1	0.01	Orthogroups_2024-Update
HORVU7Hr1G051260.3	No alias	3-hydroxy-3-methylglutaryl-CoA reductase & EC_1.1...	0.02	Orthogroups_2024-Update
MA_10426891g0010	No alias	(o64966\|hmdh1_goshi : 518.0)...	0.05	Orthogroups_2024-Update
PSME_00003399-RA	No alias	(q01559\|hmdh_nicsy : 734.0)...	0.04	Orthogroups_2024-Update
PSME_00003404-RA	No alias	(p48020\|hmdh1_soltu : 749.0)...	0.04	Orthogroups_2024-Update
Pp1s61_10V6	No alias	3-hydroxy-3-methylglutaryl coenzyme a reductase	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0015936	coenzyme A metabolic process	IEA	InterProScan predictions
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0033865	nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	IEA	InterProScan predictions
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004144	diacylglycerol O-acyltransferase activity	IEP	Predicted GO
MF	GO:0004857	enzyme inhibitor activity	IEP	Predicted GO
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0004867	serine-type endopeptidase inhibitor activity	IEP	Predicted GO
BP	GO:0006820	anion transport	IEP	Predicted GO
BP	GO:0006835	dicarboxylic acid transport	IEP	Predicted GO
BP	GO:0006950	response to stress	IEP	Predicted GO
BP	GO:0006952	defense response	IEP	Predicted GO
MF	GO:0008374	O-acyltransferase activity	IEP	Predicted GO
BP	GO:0009605	response to external stimulus	IEP	Predicted GO
BP	GO:0009607	response to biotic stimulus	IEP	Predicted GO
BP	GO:0009617	response to bacterium	IEP	Predicted GO
BP	GO:0009620	response to fungus	IEP	Predicted GO
BP	GO:0009719	response to endogenous stimulus	IEP	Predicted GO
BP	GO:0009725	response to hormone	IEP	Predicted GO
BP	GO:0009733	response to auxin	IEP	Predicted GO
BP	GO:0010033	response to organic substance	IEP	Predicted GO
BP	GO:0015711	organic anion transport	IEP	Predicted GO
BP	GO:0015740	C4-dicarboxylate transport	IEP	Predicted GO
BP	GO:0015743	malate transport	IEP	Predicted GO
BP	GO:0015849	organic acid transport	IEP	Predicted GO
MF	GO:0016411	acylglycerol O-acyltransferase activity	IEP	Predicted GO
MF	GO:0030234	enzyme regulator activity	IEP	Predicted GO
MF	GO:0030414	peptidase inhibitor activity	IEP	Predicted GO
BP	GO:0040008	regulation of growth	IEP	Predicted GO
BP	GO:0042221	response to chemical	IEP	Predicted GO
BP	GO:0042742	defense response to bacterium	IEP	Predicted GO
BP	GO:0043207	response to external biotic stimulus	IEP	Predicted GO
BP	GO:0045017	glycerolipid biosynthetic process	IEP	Predicted GO
BP	GO:0045926	negative regulation of growth	IEP	Predicted GO
BP	GO:0046486	glycerolipid metabolic process	IEP	Predicted GO
BP	GO:0046942	carboxylic acid transport	IEP	Predicted GO
BP	GO:0048519	negative regulation of biological process	IEP	Predicted GO
BP	GO:0050832	defense response to fungus	IEP	Predicted GO
BP	GO:0050896	response to stimulus	IEP	Predicted GO
BP	GO:0051704	multi-organism process	IEP	Predicted GO
BP	GO:0051707	response to other organism	IEP	Predicted GO
MF	GO:0061134	peptidase regulator activity	IEP	Predicted GO
MF	GO:0061135	endopeptidase regulator activity	IEP	Predicted GO
BP	GO:0098542	defense response to other organism	IEP	Predicted GO
MF	GO:0098772	molecular function regulator	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002202	HMG_CoA_Rdtase	260	449
IPR002202	HMG_CoA_Rdtase	447	556

External Links

No external refs found!

MA_16234g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation