MA_60257g0010

Description : (q9m4w3|ispf_catro : 299.0) 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplast precursor (EC 4.6.1.12) (MECPS) (MECDP-synthase) - Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) & (at1g63970 : 291.0) Encodes a protein with 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. The protein's activity was confirmed by heterologous expression of phenotypic complementation of the E. coli ispF mutant. Plants defective in this gene display an albino lethal phenotype.; isoprenoid F (ISPF); FUNCTIONS IN: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; INVOLVED IN: chlorophyll biosynthetic process, carotenoid biosynthetic process, response to light stimulus, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core (InterPro:IPR003526); Has 6449 Blast hits to 6448 proteins in 2092 species: Archae - 0; Bacteria - 4352; Metazoa - 0; Fungi - 4; Plants - 64; Viruses - 0; Other Eukaryotes - 2029 (source: NCBI BLink). & (reliability: 582.0) & (original description: no original description)

Gene families : OG_42_0006252 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0006252_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Picea release: MA_60257g0010
Cluster	HCCA clusters: Cluster_257

Target	Alias	Description	ECC score	Gene Family Method	Actions
A4A49_10799	No alias	2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,...	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006720	isoprenoid metabolic process	None	Extended
BP	GO:0006721	terpenoid metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008299	isoprenoid biosynthetic process	None	Extended
BP	GO:0008610	lipid biosynthetic process	None	Extended
MF	GO:0008685	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	IEA	InterProScan predictions
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016114	terpenoid biosynthetic process	IEA	InterProScan predictions
MF	GO:0016829	lyase activity	None	Extended
MF	GO:0016849	phosphorus-oxygen lyase activity	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0003333	amino acid transmembrane transport	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	IEP	Predicted GO
MF	GO:0004609	phosphatidylserine decarboxylase activity	IEP	Predicted GO
MF	GO:0005092	GDP-dissociation inhibitor activity	IEP	Predicted GO
MF	GO:0005094	Rho GDP-dissociation inhibitor activity	IEP	Predicted GO
CC	GO:0005779	integral component of peroxisomal membrane	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006417	regulation of translation	IEP	Predicted GO
BP	GO:0006448	regulation of translational elongation	IEP	Predicted GO
BP	GO:0006449	regulation of translational termination	IEP	Predicted GO
BP	GO:0006452	translational frameshifting	IEP	Predicted GO
BP	GO:0006528	asparagine metabolic process	IEP	Predicted GO
BP	GO:0006529	asparagine biosynthetic process	IEP	Predicted GO
BP	GO:0006644	phospholipid metabolic process	IEP	Predicted GO
BP	GO:0006865	amino acid transport	IEP	Predicted GO
BP	GO:0006996	organelle organization	IEP	Predicted GO
MF	GO:0008135	translation factor activity, RNA binding	IEP	Predicted GO
BP	GO:0008654	phospholipid biosynthetic process	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009891	positive regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0009893	positive regulation of metabolic process	IEP	Predicted GO
BP	GO:0010557	positive regulation of macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0010604	positive regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Predicted GO
BP	GO:0010628	positive regulation of gene expression	IEP	Predicted GO
BP	GO:0015711	organic anion transport	IEP	Predicted GO
BP	GO:0015849	organic acid transport	IEP	Predicted GO
BP	GO:0016559	peroxisome fission	IEP	Predicted GO
MF	GO:0016831	carboxy-lyase activity	IEP	Predicted GO
MF	GO:0016879	ligase activity, forming carbon-nitrogen bonds	IEP	Predicted GO
MF	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEP	Predicted GO
MF	GO:0030695	GTPase regulator activity	IEP	Predicted GO
CC	GO:0031231	intrinsic component of peroxisomal membrane	IEP	Predicted GO
CC	GO:0031300	intrinsic component of organelle membrane	IEP	Predicted GO
CC	GO:0031301	integral component of organelle membrane	IEP	Predicted GO
BP	GO:0031325	positive regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031328	positive regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0032268	regulation of cellular protein metabolic process	IEP	Predicted GO
BP	GO:0032270	positive regulation of cellular protein metabolic process	IEP	Predicted GO
BP	GO:0034248	regulation of cellular amide metabolic process	IEP	Predicted GO
BP	GO:0034250	positive regulation of cellular amide metabolic process	IEP	Predicted GO
MF	GO:0043021	ribonucleoprotein complex binding	IEP	Predicted GO
MF	GO:0043022	ribosome binding	IEP	Predicted GO
BP	GO:0043243	positive regulation of protein complex disassembly	IEP	Predicted GO
BP	GO:0043244	regulation of protein complex disassembly	IEP	Predicted GO
CC	GO:0044438	microbody part	IEP	Predicted GO
CC	GO:0044439	peroxisomal part	IEP	Predicted GO
MF	GO:0044877	protein-containing complex binding	IEP	Predicted GO
BP	GO:0045727	positive regulation of translation	IEP	Predicted GO
BP	GO:0045901	positive regulation of translational elongation	IEP	Predicted GO
BP	GO:0045905	positive regulation of translational termination	IEP	Predicted GO
BP	GO:0046942	carboxylic acid transport	IEP	Predicted GO
BP	GO:0048285	organelle fission	IEP	Predicted GO
BP	GO:0048518	positive regulation of biological process	IEP	Predicted GO
BP	GO:0048522	positive regulation of cellular process	IEP	Predicted GO
BP	GO:0051128	regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051130	positive regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051173	positive regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051246	regulation of protein metabolic process	IEP	Predicted GO
BP	GO:0051247	positive regulation of protein metabolic process	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
MF	GO:0060589	nucleoside-triphosphatase regulator activity	IEP	Predicted GO
BP	GO:0098656	anion transmembrane transport	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
BP	GO:1903825	organic acid transmembrane transport	IEP	Predicted GO
BP	GO:1905039	carboxylic acid transmembrane transport	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003526	MECDP_synthase	85	238

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MA_60257g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation