Description : (at3g13300 : 208.0) Encodes VCS (VARICOSE). Involved in mRNA decapping. VCS forms a mRNA decapping complex with DCP1 (At1g08370) and DCP2 (At5g13570). Unlike DCP2, VCS itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. VCS is also required for leaf development.; VARICOSE (VCS); FUNCTIONS IN: protein homodimerization activity, nucleotide binding; INVOLVED IN: mRNA catabolic process, deadenylation-independent decapping of nuclear-transcribed mRNA, leaf morphogenesis; LOCATED IN: cytosol, nucleus, cytoplasmic mRNA processing body; EXPRESSED IN: whole plant, guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat 2 (InterPro:IPR019782), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: varicose-related (TAIR:AT3G13290.1); Has 885 Blast hits to 799 proteins in 264 species: Archae - 2; Bacteria - 218; Metazoa - 230; Fungi - 185; Plants - 114; Viruses - 4; Other Eukaryotes - 132 (source: NCBI BLink). & (reliability: 416.0) & (original description: no original description)
Gene families : OG_42_0001770 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001770_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
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Neighborhood | Picea release: MA_6918297g0010 | |
Cluster | HCCA clusters: Cluster_30 |
Type | GO Term | Name | Evidence | Source |
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No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
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CC | GO:0005739 | mitochondrion | IEP | Predicted GO |
BP | GO:0030001 | metal ion transport | IEP | Predicted GO |
CC | GO:0031225 | anchored component of membrane | IEP | Predicted GO |
CC | GO:0031226 | intrinsic component of plasma membrane | IEP | Predicted GO |
CC | GO:0044459 | plasma membrane part | IEP | Predicted GO |
CC | GO:0046658 | anchored component of plasma membrane | IEP | Predicted GO |
No InterPro domains available for this sequence
No external refs found! |