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  5. MA_7676293g0010

MA_7676293g0010


Description : (at1g22940 : 459.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 918.0) & (original description: no original description)


Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


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Type Description Actions
Neighborhood Picea release: MA_7676293g0010
Cluster HCCA clusters: Cluster_177


Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source

No Predicted GO terms available for this sequence
InterPro domains Description Start Stop
IPR022998 ThiamineP_synth_TenI 155 339
IPR013749 PM/HMP-P_kinase-1 2 126
No external refs found!