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- MA_80165g0010
MA_80165g0010
Description : (at1g08260 : 787.0) Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells.; TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink). & (reliability: 1574.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Picea release: MA_80165g0010 | |
| Cluster | HCCA clusters: Cluster_182 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| Brara.F00511.1 | No alias | catalytic component *(POL2/POLE1) of DNA polymerase... | 0.03 | Orthogroups_2024-Update | |
| Cre03.g179961 | No alias | DNA polymerase epsilon catalytic subunit | 0.03 | Orthogroups_2024-Update | |
| Kfl00061_0280 | kfl00061_0280_v1.1 | (at1g08260 : 1660.0) Similar to POL2A, DNA polymerase... | 0.03 | Orthogroups_2024-Update | |
| evm.model.tig00000970.31 | No alias | (at1g08260 : 86.3) Similar to POL2A, DNA polymerase... | 0.02 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0003887 | DNA-directed DNA polymerase activity | IEA | InterProScan predictions |
| MF | GO:0005488 | binding | None | Extended |
| CC | GO:0005575 | cellular_component | None | Extended |
| CC | GO:0005634 | nucleus | IEA | InterProScan predictions |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
| BP | GO:0006259 | DNA metabolic process | None | Extended |
| BP | GO:0006260 | DNA replication | IEA | InterProScan predictions |
| BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| MF | GO:0008270 | zinc ion binding | IEA | InterProScan predictions |
| BP | GO:0009058 | biosynthetic process | None | Extended |
| BP | GO:0009059 | macromolecule biosynthetic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0016740 | transferase activity | None | Extended |
| MF | GO:0016772 | transferase activity, transferring phosphorus-containing groups | None | Extended |
| MF | GO:0016779 | nucleotidyltransferase activity | None | Extended |
| MF | GO:0034061 | DNA polymerase activity | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| BP | GO:0034645 | cellular macromolecule biosynthetic process | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043169 | cation binding | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| CC | GO:0043226 | organelle | None | Extended |
| CC | GO:0043227 | membrane-bounded organelle | None | Extended |
| CC | GO:0043229 | intracellular organelle | None | Extended |
| CC | GO:0043231 | intracellular membrane-bounded organelle | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044249 | cellular biosynthetic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| CC | GO:0044424 | intracellular part | None | Extended |
| CC | GO:0044464 | cell part | None | Extended |
| BP | GO:0046483 | heterocycle metabolic process | None | Extended |
| MF | GO:0046872 | metal ion binding | None | Extended |
| MF | GO:0046914 | transition metal ion binding | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
| MF | GO:0140097 | catalytic activity, acting on DNA | None | Extended |
| BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
| BP | GO:1901576 | organic substance biosynthetic process | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| CC | GO:0000148 | 1,3-beta-D-glucan synthase complex | IEP | Predicted GO |
| MF | GO:0003682 | chromatin binding | IEP | Predicted GO |
| MF | GO:0003843 | 1,3-beta-D-glucan synthase activity | IEP | Predicted GO |
| BP | GO:0006074 | (1->3)-beta-D-glucan metabolic process | IEP | Predicted GO |
| BP | GO:0006075 | (1->3)-beta-D-glucan biosynthetic process | IEP | Predicted GO |
| CC | GO:0044459 | plasma membrane part | IEP | Predicted GO |
| CC | GO:0098797 | plasma membrane protein complex | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR013697 | DNA_pol_e_suA_C | 221 | 582 |
