evm.model.contig_2042.4

Description : (at1g44900 : 727.0) Encodes MCM2 (MINICHROMOSOME MAINTENANCE 2), a protein essential to embryo development. Overexpression results in altered root meristem function.; MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1). & (q43704|mcm3_maize : 303.0) DNA replication licensing factor MCM3 homolog (Replication origin activator) (ROA protein) (Fragment) - Zea mays (Maize) & (reliability: 1454.0) & (original description: no original description)

Gene families : OG_42_0007133 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0007133_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Porphyridium release: evm.model.contig_2042.4
Cluster	HCCA clusters: Cluster_4

Target	Alias	Description	ECC score	Gene Family Method
A4A49_15623	No alias	dna replication licensing factor mcm2	0.04	Orthogroups_2024-Update
At1g44900	No alias	DNA replication licensing factor MCM2...	0.04	Orthogroups_2024-Update
Bradi4g19207	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.06	Orthogroups_2024-Update
Brara.J00584.1	No alias	component *(MCM2) of MCM replicative DNA helicase complex	0.1	Orthogroups_2024-Update
Cre07.g338000	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.06	Orthogroups_2024-Update
GRMZM2G139894	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.02	Orthogroups_2024-Update
Glyma.07G238400	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.09	Orthogroups_2024-Update
Glyma.17G035000	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.1	Orthogroups_2024-Update
HORVU1Hr1G063700.2	No alias	component *(MCM2) of MCM replicative DNA helicase complex	0.05	Orthogroups_2024-Update
Kfl00422_0010	kfl00422_0010_v1.1	(at1g44900 : 989.0) Encodes MCM2 (MINICHROMOSOME...	0.07	Orthogroups_2024-Update
Mp3g00130.1	No alias	component MCM2 of MCM replicative DNA helicase complex	0.05	Orthogroups_2024-Update
Potri.001G070500	No alias	minichromosome maintenance (MCM2/3/5) family protein	0.03	Orthogroups_2024-Update
Pp1s28_266V6	No alias	dna replication licensing factor	0.03	Orthogroups_2024-Update
Seita.8G121500.1	No alias	component *(MCM2) of MCM replicative DNA helicase complex	0.11	Orthogroups_2024-Update
Sobic.005G110535.1	No alias	component *(MCM2) of MCM replicative DNA helicase complex	0.09	Orthogroups_2024-Update
Solyc11g040120	No alias	DNA helicase (AHRD V3.3 *** M0ZQ54_SOLTU)	0.05	Orthogroups_2024-Update
Sopen11g017320	No alias	MCM2/3/5 family	0.06	Orthogroups_2024-Update
evm.model.tig00020554.77	No alias	(at1g44900 : 595.0) Encodes MCM2 (MINICHROMOSOME...	0.06	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006270	DNA replication initiation	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010639	negative regulation of organelle organization	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033043	regulation of organelle organization	None	Extended
BP	GO:0033044	regulation of chromosome organization	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
CC	GO:0042555	MCM complex	IEA	InterProScan predictions
BP	GO:0043086	negative regulation of catalytic activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044092	negative regulation of molecular function	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048523	negative regulation of cellular process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050790	regulation of catalytic activity	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0051095	regulation of helicase activity	None	Extended
BP	GO:0051097	negative regulation of helicase activity	None	Extended
BP	GO:0051128	regulation of cellular component organization	None	Extended
BP	GO:0051129	negative regulation of cellular component organization	None	Extended
BP	GO:0051336	regulation of hydrolase activity	None	Extended
BP	GO:0051346	negative regulation of hydrolase activity	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0065009	regulation of molecular function	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1905462	regulation of DNA duplex unwinding	None	Extended
BP	GO:1905463	negative regulation of DNA duplex unwinding	None	Extended
BP	GO:1905774	regulation of DNA helicase activity	None	Extended
BP	GO:1905775	negative regulation of DNA helicase activity	IEA	InterProScan predictions
BP	GO:2001251	negative regulation of chromosome organization	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Predicted GO
MF	GO:0003896	DNA primase activity	IEP	Predicted GO
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Predicted GO
BP	GO:0006260	DNA replication	IEP	Predicted GO
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Predicted GO
BP	GO:0006275	regulation of DNA replication	IEP	Predicted GO
BP	GO:0006310	DNA recombination	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0032774	RNA biosynthetic process	IEP	Predicted GO
MF	GO:0034061	DNA polymerase activity	IEP	Predicted GO
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0051052	regulation of DNA metabolic process	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
MF	GO:0097747	RNA polymerase activity	IEP	Predicted GO
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR033762	MCM_OB	386	513
IPR008045	MCM2	99	187
IPR001208	MCM_dom	554	776
IPR027925	MCM_N	287	369

External Links

No external refs found!

evm.model.contig_2042.4

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation