Description : (at5g26780 : 637.0) Encodes a protein with serine hydroxymethyltransferase activity which is thought to be localized in the mitochondrial matrix. SHM2 expression fails to rescue the conditional lethal phenotype of the shm1-1 mutant, defective in SHM1.; serine hydroxymethyltransferase 2 (SHM2); FUNCTIONS IN: glycine hydroxymethyltransferase activity, cobalt ion binding, zinc ion binding; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: mitochondrion, mitochondrial respiratory chain complex I; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 11562 Blast hits to 11539 proteins in 2821 species: Archae - 258; Bacteria - 6362; Metazoa - 333; Fungi - 287; Plants - 321; Viruses - 6; Other Eukaryotes - 3995 (source: NCBI BLink). & (p50433|glym_soltu : 634.0) Serine hydroxymethyltransferase, mitochondrial precursor (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT) - Solanum tuberosum (Potato) & (reliability: 1154.0) & (original description: no original description)
Gene families : OG_42_0000626 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000626_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Porphyridium release: evm.model.contig_2050.3 | |
Cluster | HCCA clusters: Cluster_28 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
A4A49_22571 | No alias | serine hydroxymethyltransferase 3, chloroplastic | 0.01 | Orthogroups_2024-Update | |
A4A49_25960 | No alias | serine hydroxymethyltransferase, mitochondrial | 0.02 | Orthogroups_2024-Update | |
Brara.A00108.1 | No alias | serine hydroxymethyltransferase *(SHM) & serine... | 0.02 | Orthogroups_2024-Update | |
Brara.H01745.1 | No alias | serine hydroxymethyltransferase & EC_2.1 transferase... | 0.02 | Orthogroups_2024-Update | |
Glyma.08G274400 | No alias | serine transhydroxymethyltransferase 1 | 0.01 | Orthogroups_2024-Update | |
Glyma.18G150000 | No alias | serine transhydroxymethyltransferase 1 | 0.02 | Orthogroups_2024-Update | |
Kfl00359_0090 | kfl00359_0090_v1.1 | (p34899|glym_pea : 701.0) Serine... | 0.02 | Orthogroups_2024-Update | |
PSME_00015002-RA | No alias | (p49358|glyn_flapr : 512.0) Serine... | 0.02 | Orthogroups_2024-Update | |
Pp1s21_270V6 | No alias | glycine hydroxymethyltransferase | 0.03 | Orthogroups_2024-Update | |
Sobic.001G097100.3 | No alias | serine hydroxymethyltransferase *(SHM) & serine... | 0.01 | Orthogroups_2024-Update | |
Solyc02g091560 | No alias | Serine hydroxymethyltransferase (AHRD V3.3 *** A0A0R4J3Y9_SOYBN) | 0.03 | Orthogroups_2024-Update | |
Sopen02g036190 | No alias | Serine hydroxymethyltransferase | 0.02 | Orthogroups_2024-Update | |
evm.model.tig00001130.31 | No alias | (at4g13930 : 555.0) Encodes a serine... | 0.04 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
BP | GO:0001505 | regulation of neurotransmitter levels | IEP | Predicted GO |
MF | GO:0003824 | catalytic activity | IEP | Predicted GO |
MF | GO:0004089 | carbonate dehydratase activity | IEP | Predicted GO |
MF | GO:0004177 | aminopeptidase activity | IEP | Predicted GO |
MF | GO:0004325 | ferrochelatase activity | IEP | Predicted GO |
MF | GO:0004329 | formate-tetrahydrofolate ligase activity | IEP | Predicted GO |
MF | GO:0004375 | glycine dehydrogenase (decarboxylating) activity | IEP | Predicted GO |
BP | GO:0006544 | glycine metabolic process | IEP | Predicted GO |
BP | GO:0006546 | glycine catabolic process | IEP | Predicted GO |
BP | GO:0006779 | porphyrin-containing compound biosynthetic process | IEP | Predicted GO |
BP | GO:0006783 | heme biosynthetic process | IEP | Predicted GO |
BP | GO:0006855 | drug transmembrane transport | IEP | Predicted GO |
MF | GO:0008081 | phosphoric diester hydrolase activity | IEP | Predicted GO |
BP | GO:0009063 | cellular amino acid catabolic process | IEP | Predicted GO |
BP | GO:0009069 | serine family amino acid metabolic process | IEP | Predicted GO |
BP | GO:0009071 | serine family amino acid catabolic process | IEP | Predicted GO |
BP | GO:0015893 | drug transport | IEP | Predicted GO |
BP | GO:0016054 | organic acid catabolic process | IEP | Predicted GO |
CC | GO:0016272 | prefoldin complex | IEP | Predicted GO |
MF | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors | IEP | Predicted GO |
MF | GO:0016642 | oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor | IEP | Predicted GO |
MF | GO:0016829 | lyase activity | IEP | Predicted GO |
MF | GO:0016835 | carbon-oxygen lyase activity | IEP | Predicted GO |
MF | GO:0016836 | hydro-lyase activity | IEP | Predicted GO |
BP | GO:0042133 | neurotransmitter metabolic process | IEP | Predicted GO |
BP | GO:0042135 | neurotransmitter catabolic process | IEP | Predicted GO |
BP | GO:0042168 | heme metabolic process | IEP | Predicted GO |
BP | GO:0042737 | drug catabolic process | IEP | Predicted GO |
BP | GO:0044282 | small molecule catabolic process | IEP | Predicted GO |
BP | GO:0046148 | pigment biosynthetic process | IEP | Predicted GO |
BP | GO:0046395 | carboxylic acid catabolic process | IEP | Predicted GO |
MF | GO:0048037 | cofactor binding | IEP | Predicted GO |
MF | GO:0050662 | coenzyme binding | IEP | Predicted GO |
BP | GO:1901606 | alpha-amino acid catabolic process | IEP | Predicted GO |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR039429 | SHMT-like_dom | 49 | 448 |
No external refs found! |