Description : (o48653|dpola_orysa : 558.0) DNA polymerase alpha catalytic subunit (EC 2.7.7.7) - Oryza sativa (Rice) & (at5g67100 : 531.0) Encodes the putative catalytic subunit of the DNA polymerase alpha. Interacts with genes involved in chromatin-mediated cellular memory. ICU2 genetically interacts with TERMINAL FLOWER2, the ortholog of HETEROCHROMATIN PROTEIN1 of animals and yeasts, and with the Polycomb group (PcG) gene CURLY LEAF. A number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. Mutant has curled, involute leaves and causes early flowering.; INCURVATA2 (ICU2); FUNCTIONS IN: DNA-directed DNA polymerase activity; INVOLVED IN: negative regulation of flower development, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134), Zinc finger, DNA-directed DNA polymerase, family B, alpha (InterPro:IPR015088), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved site (InterPro:IPR017964), DNA-directed DNA polymerase, family B (InterPro:IPR006172), DNA-directed DNA polymerase, family B, pol2 (InterPro:IPR004578); BEST Arabidopsis thaliana protein match is: DNA binding;nucleotide binding;nucleic acid binding;DNA-directed DNA polymerases;DNA-directed DNA polymerases (TAIR:AT5G63960.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 1062.0) & (original description: no original description)
Gene families : OG_42_0006336 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0006336_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Porphyridium release: evm.model.contig_2084.13 | |
Cluster | HCCA clusters: Cluster_4 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
232193 | No alias | DNA-directed DNA polymerases | 0.03 | Orthogroups_2024-Update | |
At5g67100 | No alias | DNA polymerase alpha catalytic subunit... | 0.02 | Orthogroups_2024-Update | |
Brara.G01198.1 | No alias | catalytic component *(POLA1) of DNA polymerase alpha complex | 0.1 | Orthogroups_2024-Update | |
Cre04.g214350 | No alias | DNA-directed DNA polymerases | 0.04 | Orthogroups_2024-Update | |
Glyma.01G187400 | No alias | DNA-directed DNA polymerases | 0.08 | Orthogroups_2024-Update | |
Kfl00349_0050 | kfl00349_0050_v1.1 | (o48653|dpola_orysa : 1124.0) DNA polymerase alpha... | 0.05 | Orthogroups_2024-Update | |
Mp7g03960.1 | No alias | catalytic component POLA1 of DNA polymerase alpha complex | 0.02 | Orthogroups_2024-Update | |
Pp1s257_37V6 | No alias | dna polymerase alpha catalytic subunit | 0.02 | Orthogroups_2024-Update | |
Seita.5G394500.1 | No alias | catalytic component *(POLA1) of DNA polymerase alpha complex | 0.02 | Orthogroups_2024-Update | |
Sobic.003G369200.2 | No alias | catalytic component *(POLA1) of DNA polymerase alpha complex | 0.02 | Orthogroups_2024-Update | |
Solyc02g093300 | No alias | DNA polymerase (AHRD V3.3 *** H9E8V2_SOLLC) | 0.06 | Orthogroups_2024-Update | |
evm.model.tig00000237.42 | No alias | (o48653|dpola_orysa : 568.0) DNA polymerase alpha... | 0.07 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0000166 | nucleotide binding | IEA | InterProScan predictions |
MF | GO:0001882 | nucleoside binding | IEA | InterProScan predictions |
MF | GO:0003677 | DNA binding | IEA | InterProScan predictions |
MF | GO:0003887 | DNA-directed DNA polymerase activity | IEA | InterProScan predictions |
BP | GO:0006260 | DNA replication | IEA | InterProScan predictions |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0003896 | DNA primase activity | IEP | Predicted GO |
MF | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | IEP | Predicted GO |
MF | GO:0005085 | guanyl-nucleotide exchange factor activity | IEP | Predicted GO |
MF | GO:0005088 | Ras guanyl-nucleotide exchange factor activity | IEP | Predicted GO |
MF | GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEP | Predicted GO |
MF | GO:0005524 | ATP binding | IEP | Predicted GO |
BP | GO:0006269 | DNA replication, synthesis of RNA primer | IEP | Predicted GO |
BP | GO:0006270 | DNA replication initiation | IEP | Predicted GO |
BP | GO:0006275 | regulation of DNA replication | IEP | Predicted GO |
BP | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | IEP | Predicted GO |
MF | GO:0008144 | drug binding | IEP | Predicted GO |
BP | GO:0009889 | regulation of biosynthetic process | IEP | Predicted GO |
BP | GO:0010556 | regulation of macromolecule biosynthetic process | IEP | Predicted GO |
BP | GO:0010639 | negative regulation of organelle organization | IEP | Predicted GO |
MF | GO:0016805 | dipeptidase activity | IEP | Predicted GO |
MF | GO:0017016 | Ras GTPase binding | IEP | Predicted GO |
MF | GO:0017048 | Rho GTPase binding | IEP | Predicted GO |
MF | GO:0017076 | purine nucleotide binding | IEP | Predicted GO |
BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | IEP | Predicted GO |
BP | GO:0019222 | regulation of metabolic process | IEP | Predicted GO |
BP | GO:0019720 | Mo-molybdopterin cofactor metabolic process | IEP | Predicted GO |
MF | GO:0030554 | adenyl nucleotide binding | IEP | Predicted GO |
MF | GO:0031267 | small GTPase binding | IEP | Predicted GO |
BP | GO:0031323 | regulation of cellular metabolic process | IEP | Predicted GO |
BP | GO:0031326 | regulation of cellular biosynthetic process | IEP | Predicted GO |
MF | GO:0032553 | ribonucleotide binding | IEP | Predicted GO |
MF | GO:0032555 | purine ribonucleotide binding | IEP | Predicted GO |
MF | GO:0032559 | adenyl ribonucleotide binding | IEP | Predicted GO |
BP | GO:0033043 | regulation of organelle organization | IEP | Predicted GO |
BP | GO:0033044 | regulation of chromosome organization | IEP | Predicted GO |
MF | GO:0034062 | 5'-3' RNA polymerase activity | IEP | Predicted GO |
MF | GO:0035639 | purine ribonucleoside triphosphate binding | IEP | Predicted GO |
CC | GO:0042555 | MCM complex | IEP | Predicted GO |
BP | GO:0043086 | negative regulation of catalytic activity | IEP | Predicted GO |
MF | GO:0043168 | anion binding | IEP | Predicted GO |
BP | GO:0043545 | molybdopterin cofactor metabolic process | IEP | Predicted GO |
BP | GO:0044092 | negative regulation of molecular function | IEP | Predicted GO |
BP | GO:0050789 | regulation of biological process | IEP | Predicted GO |
BP | GO:0050794 | regulation of cellular process | IEP | Predicted GO |
BP | GO:0051052 | regulation of DNA metabolic process | IEP | Predicted GO |
BP | GO:0051095 | regulation of helicase activity | IEP | Predicted GO |
BP | GO:0051097 | negative regulation of helicase activity | IEP | Predicted GO |
BP | GO:0051128 | regulation of cellular component organization | IEP | Predicted GO |
BP | GO:0051129 | negative regulation of cellular component organization | IEP | Predicted GO |
BP | GO:0051171 | regulation of nitrogen compound metabolic process | IEP | Predicted GO |
BP | GO:0051189 | prosthetic group metabolic process | IEP | Predicted GO |
BP | GO:0051336 | regulation of hydrolase activity | IEP | Predicted GO |
BP | GO:0051346 | negative regulation of hydrolase activity | IEP | Predicted GO |
BP | GO:0060255 | regulation of macromolecule metabolic process | IEP | Predicted GO |
BP | GO:0065007 | biological regulation | IEP | Predicted GO |
BP | GO:0080090 | regulation of primary metabolic process | IEP | Predicted GO |
MF | GO:0097747 | RNA polymerase activity | IEP | Predicted GO |
BP | GO:1905462 | regulation of DNA duplex unwinding | IEP | Predicted GO |
BP | GO:1905463 | negative regulation of DNA duplex unwinding | IEP | Predicted GO |
BP | GO:1905774 | regulation of DNA helicase activity | IEP | Predicted GO |
BP | GO:1905775 | negative regulation of DNA helicase activity | IEP | Predicted GO |
BP | GO:2000112 | regulation of cellular macromolecule biosynthetic process | IEP | Predicted GO |
BP | GO:2001251 | negative regulation of chromosome organization | IEP | Predicted GO |
No external refs found! |