evm.model.contig_2137.2

Description : (at4g25540 : 370.0) encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH3 heterodimers bound 'insertion-deletion' DNA with three nucleotides (+AAG) or one nucleotide (+T) looped out much better than they bound DNA with a base/base mispair (T/G).; homolog of DNA mismatch repair protein MSH3 (MSH3); CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 14547 Blast hits to 13713 proteins in 2703 species: Archae - 153; Bacteria - 9793; Metazoa - 705; Fungi - 864; Plants - 451; Viruses - 3; Other Eukaryotes - 2578 (source: NCBI BLink). & (q9xgc9|msh2_maize : 169.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 740.0) & (original description: no original description)

Gene families : OG_42_0004732 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004732_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Porphyridium release: evm.model.contig_2137.2
Cluster	HCCA clusters: Cluster_38

Target	Alias	Description	ECC score	Gene Family Method	Actions
MA_540053g0010	No alias	(at4g25540 : 186.0) encodes a DNA mismatch repair...	0.02	Orthogroups_2024-Update
Mp1g06710.1	No alias	component MSH3 of MSH2-x mismatch repair heterodimers	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	InterProScan predictions
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000075	cell cycle checkpoint	IEP	Predicted GO
MF	GO:0003689	DNA clamp loader activity	IEP	Predicted GO
MF	GO:0004525	ribonuclease III activity	IEP	Predicted GO
CC	GO:0005634	nucleus	IEP	Predicted GO
CC	GO:0005663	DNA replication factor C complex	IEP	Predicted GO
BP	GO:0006333	chromatin assembly or disassembly	IEP	Predicted GO
BP	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	IEP	Predicted GO
BP	GO:0006904	vesicle docking involved in exocytosis	IEP	Predicted GO
BP	GO:0007088	regulation of mitotic nuclear division	IEP	Predicted GO
BP	GO:0007093	mitotic cell cycle checkpoint	IEP	Predicted GO
BP	GO:0007094	mitotic spindle assembly checkpoint	IEP	Predicted GO
BP	GO:0007346	regulation of mitotic cell cycle	IEP	Predicted GO
BP	GO:0010564	regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010639	negative regulation of organelle organization	IEP	Predicted GO
BP	GO:0010948	negative regulation of cell cycle process	IEP	Predicted GO
BP	GO:0010965	regulation of mitotic sister chromatid separation	IEP	Predicted GO
MF	GO:0015095	magnesium ion transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015693	magnesium ion transport	IEP	Predicted GO
MF	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
BP	GO:0022402	cell cycle process	IEP	Predicted GO
BP	GO:0022406	membrane docking	IEP	Predicted GO
BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	IEP	Predicted GO
BP	GO:0031577	spindle checkpoint	IEP	Predicted GO
MF	GO:0032296	double-stranded RNA-specific ribonuclease activity	IEP	Predicted GO
BP	GO:0033043	regulation of organelle organization	IEP	Predicted GO
BP	GO:0033044	regulation of chromosome organization	IEP	Predicted GO
BP	GO:0033045	regulation of sister chromatid segregation	IEP	Predicted GO
BP	GO:0033046	negative regulation of sister chromatid segregation	IEP	Predicted GO
BP	GO:0033047	regulation of mitotic sister chromatid segregation	IEP	Predicted GO
BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	IEP	Predicted GO
MF	GO:0033170	protein-DNA loading ATPase activity	IEP	Predicted GO
MF	GO:0042623	ATPase activity, coupled	IEP	Predicted GO
BP	GO:0045786	negative regulation of cell cycle	IEP	Predicted GO
BP	GO:0045839	negative regulation of mitotic nuclear division	IEP	Predicted GO
BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	IEP	Predicted GO
BP	GO:0045930	negative regulation of mitotic cell cycle	IEP	Predicted GO
BP	GO:0048278	vesicle docking	IEP	Predicted GO
BP	GO:0051128	regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051129	negative regulation of cellular component organization	IEP	Predicted GO
BP	GO:0051640	organelle localization	IEP	Predicted GO
BP	GO:0051783	regulation of nuclear division	IEP	Predicted GO
BP	GO:0051784	negative regulation of nuclear division	IEP	Predicted GO
BP	GO:0051983	regulation of chromosome segregation	IEP	Predicted GO
BP	GO:0051985	negative regulation of chromosome segregation	IEP	Predicted GO
BP	GO:0070838	divalent metal ion transport	IEP	Predicted GO
BP	GO:0071173	spindle assembly checkpoint	IEP	Predicted GO
BP	GO:0071174	mitotic spindle checkpoint	IEP	Predicted GO
BP	GO:0072511	divalent inorganic cation transport	IEP	Predicted GO
BP	GO:0140029	exocytic process	IEP	Predicted GO
BP	GO:0140056	organelle localization by membrane tethering	IEP	Predicted GO
BP	GO:1901987	regulation of cell cycle phase transition	IEP	Predicted GO
BP	GO:1901988	negative regulation of cell cycle phase transition	IEP	Predicted GO
BP	GO:1901990	regulation of mitotic cell cycle phase transition	IEP	Predicted GO
BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	IEP	Predicted GO
BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	IEP	Predicted GO
BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	IEP	Predicted GO
BP	GO:1903047	mitotic cell cycle process	IEP	Predicted GO
BP	GO:1905818	regulation of chromosome separation	IEP	Predicted GO
BP	GO:1905819	negative regulation of chromosome separation	IEP	Predicted GO
BP	GO:2000816	negative regulation of mitotic sister chromatid separation	IEP	Predicted GO
BP	GO:2001251	negative regulation of chromosome organization	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR007696	DNA_mismatch_repair_MutS_core	443	792
IPR007861	DNA_mismatch_repair_MutS_clamp	667	750
IPR007695	DNA_mismatch_repair_MutS-lik_N	157	272
IPR000432	DNA_mismatch_repair_MutS_C	854	1050

External Links

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evm.model.contig_2137.2

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation