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- evm.model.contig_3436.5
evm.model.contig_3436.5
Description : (at3g18524 : 456.0) Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.; MUTS homolog 2 (MSH2); FUNCTIONS IN: damaged DNA binding, protein binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, negative regulation of reciprocal meiotic recombination; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein, MSH2 (InterPro:IPR011184); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 13560 Blast hits to 13453 proteins in 2654 species: Archae - 128; Bacteria - 8942; Metazoa - 734; Fungi - 813; Plants - 457; Viruses - 3; Other Eukaryotes - 2483 (source: NCBI BLink). & (q9xgc9|msh2_maize : 412.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 912.0) & (original description: no original description)
Expression Profile
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Porphyridium release: evm.model.contig_3436.5 | |
| Cluster | HCCA clusters: Cluster_60 | |
Expression Context Conservation (ECC)
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
| Kfl00626_0050 | kfl00626_0050_v1.1 | (at3g18524 : 1095.0) Encodes a DNA mismatch repair... | 0.02 | Orthogroups_2024-Update | |
| Mp4g08420.1 | No alias | component MSH2 of MSH2-x mismatch repair heterodimers | 0.02 | Orthogroups_2024-Update | |
| Sobic.002G362200.1 | No alias | component *(MSH2) of MSH2-x mismatch repair heterodimers | 0.02 | Orthogroups_2024-Update | |
| Solyc06g069230 | No alias | DNA mismatch repair protein (AHRD V3.3 *** Q6DQL7_PETHY) | 0.03 | Orthogroups_2024-Update | |
| evm.model.tig00001224.8 | No alias | (at3g18524 : 614.0) Encodes a DNA mismatch repair... | 0.03 | Orthogroups_2024-Update | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | None | Extended |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003676 | nucleic acid binding | None | Extended |
| MF | GO:0003677 | DNA binding | None | Extended |
| MF | GO:0003690 | double-stranded DNA binding | None | Extended |
| MF | GO:0005488 | binding | None | Extended |
| MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
| BP | GO:0006259 | DNA metabolic process | None | Extended |
| BP | GO:0006281 | DNA repair | None | Extended |
| BP | GO:0006298 | mismatch repair | IEA | InterProScan predictions |
| BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0006950 | response to stress | None | Extended |
| BP | GO:0006974 | cellular response to DNA damage stimulus | None | Extended |
| MF | GO:0008144 | drug binding | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| MF | GO:0017076 | purine nucleotide binding | None | Extended |
| MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
| MF | GO:0030983 | mismatched DNA binding | IEA | InterProScan predictions |
| MF | GO:0032553 | ribonucleotide binding | None | Extended |
| MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
| MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
| BP | GO:0033554 | cellular response to stress | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
| MF | GO:0036094 | small molecule binding | None | Extended |
| MF | GO:0043167 | ion binding | None | Extended |
| MF | GO:0043168 | anion binding | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| BP | GO:0046483 | heterocycle metabolic process | None | Extended |
| BP | GO:0050896 | response to stimulus | None | Extended |
| BP | GO:0051716 | cellular response to stimulus | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
| MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
| BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000062 | fatty-acyl-CoA binding | IEP | Predicted GO |
| MF | GO:0003864 | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity | IEP | Predicted GO |
| MF | GO:0003896 | DNA primase activity | IEP | Predicted GO |
| MF | GO:0004557 | alpha-galactosidase activity | IEP | Predicted GO |
| MF | GO:0004779 | sulfate adenylyltransferase activity | IEP | Predicted GO |
| MF | GO:0004781 | sulfate adenylyltransferase (ATP) activity | IEP | Predicted GO |
| BP | GO:0006269 | DNA replication, synthesis of RNA primer | IEP | Predicted GO |
| BP | GO:0006275 | regulation of DNA replication | IEP | Predicted GO |
| MF | GO:0015925 | galactosidase activity | IEP | Predicted GO |
| BP | GO:0015939 | pantothenate metabolic process | IEP | Predicted GO |
| BP | GO:0015940 | pantothenate biosynthetic process | IEP | Predicted GO |
| MF | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity | IEP | Predicted GO |
| MF | GO:0016779 | nucleotidyltransferase activity | IEP | Predicted GO |
| BP | GO:0031123 | RNA 3'-end processing | IEP | Predicted GO |
| BP | GO:0031124 | mRNA 3'-end processing | IEP | Predicted GO |
| MF | GO:0033218 | amide binding | IEP | Predicted GO |
| BP | GO:0042398 | cellular modified amino acid biosynthetic process | IEP | Predicted GO |
| BP | GO:0051052 | regulation of DNA metabolic process | IEP | Predicted GO |
| MF | GO:0051537 | 2 iron, 2 sulfur cluster binding | IEP | Predicted GO |
| BP | GO:0061024 | membrane organization | IEP | Predicted GO |
| MF | GO:0070403 | NAD+ binding | IEP | Predicted GO |
| MF | GO:0070566 | adenylyltransferase activity | IEP | Predicted GO |
| BP | GO:0120009 | intermembrane lipid transfer | IEP | Predicted GO |
| MF | GO:0120013 | intermembrane lipid transfer activity | IEP | Predicted GO |
| MF | GO:1901567 | fatty acid derivative binding | IEP | Predicted GO |
| MF | GO:1901681 | sulfur compound binding | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR007860 | DNA_mmatch_repair_MutS_con_dom | 195 | 317 |
| IPR007696 | DNA_mismatch_repair_MutS_core | 348 | 662 |
| IPR007861 | DNA_mismatch_repair_MutS_clamp | 521 | 621 |
| IPR000432 | DNA_mismatch_repair_MutS_C | 745 | 934 |
