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  5. evm.model.contig_4432.5

evm.model.contig_4432.5


Description : (at1g22940 : 177.0) Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media.; THIAMINE REQUIRING 1 (TH1); FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity; INVOLVED IN: thiamin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Phosphomethylpyrimidine kinase type-2 (InterPro:IPR004399), Aldolase-type TIM barrel (InterPro:IPR013785), Phosphomethylpyrimidine kinase type-1 (InterPro:IPR013749); Has 15989 Blast hits to 15891 proteins in 2548 species: Archae - 338; Bacteria - 12149; Metazoa - 165; Fungi - 331; Plants - 107; Viruses - 0; Other Eukaryotes - 2899 (source: NCBI BLink). & (reliability: 354.0) & (original description: no original description)


Gene families : OG_42_0005927 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0005927_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Porphyridium release: evm.model.contig_4432.5
Cluster HCCA clusters: Cluster_34

Target Alias Description ECC score Gene Family Method Actions
Mp5g15420.1 No alias bifunctional hydroxymethylpyrimidine kinase and... 0.02 Orthogroups_2024-Update

Type GO Term Name Evidence Source

No GO annotation available for this sequence
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Type GO Term Name Evidence Source
MF GO:0004177 aminopeptidase activity IEP Predicted GO
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Predicted GO
MF GO:0004820 glycine-tRNA ligase activity IEP Predicted GO
MF GO:0004827 proline-tRNA ligase activity IEP Predicted GO
CC GO:0005737 cytoplasm IEP Predicted GO
BP GO:0006399 tRNA metabolic process IEP Predicted GO
BP GO:0006418 tRNA aminoacylation for protein translation IEP Predicted GO
BP GO:0006426 glycyl-tRNA aminoacylation IEP Predicted GO
BP GO:0006433 prolyl-tRNA aminoacylation IEP Predicted GO
BP GO:0009143 nucleoside triphosphate catabolic process IEP Predicted GO
BP GO:0010207 photosystem II assembly IEP Predicted GO
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Predicted GO
BP GO:0019725 cellular homeostasis IEP Predicted GO
BP GO:0042592 homeostatic process IEP Predicted GO
BP GO:0043038 amino acid activation IEP Predicted GO
BP GO:0043039 tRNA aminoacylation IEP Predicted GO
BP GO:0045454 cell redox homeostasis IEP Predicted GO
MF GO:0047429 nucleoside-triphosphate diphosphatase activity IEP Predicted GO
BP GO:0065008 regulation of biological quality IEP Predicted GO
MF GO:0070567 cytidylyltransferase activity IEP Predicted GO
MF GO:0140101 catalytic activity, acting on a tRNA IEP Predicted GO
InterPro domains Description Start Stop
IPR013749 PM/HMP-P_kinase-1 13 257
No external refs found!