177513

Description : hydroxy methylglutaryl CoA reductase 1

Gene families : OG_42_0001334 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001334_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Selaginella: 177513
Cluster	HCCA clusters: Cluster_140

Target	Alias	Description	ECC score	Gene Family Method
MA_363692g0010	No alias	(o64966\|hmdh1_goshi : 646.0)...	0.02	Orthogroups_2024-Update
Potri.002G004000	No alias	hydroxy methylglutaryl CoA reductase 1	0.02	Orthogroups_2024-Update
Seita.2G257000.1	No alias	3-hydroxy-3-methylglutaryl-CoA reductase & EC_1.1...	0.02	Orthogroups_2024-Update
Solyc02g082260	No alias	3-hydroxy-3-methylglutaryl CoA reductase	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006163	purine nucleotide metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006753	nucleoside phosphate metabolic process	None	Extended
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009117	nucleotide metabolic process	None	Extended
BP	GO:0009150	purine ribonucleotide metabolic process	None	Extended
BP	GO:0009259	ribonucleotide metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0015936	coenzyme A metabolic process	IEA	InterProScan predictions
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	None	Extended
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019637	organophosphate metabolic process	None	Extended
BP	GO:0019693	ribose phosphate metabolic process	None	Extended
BP	GO:0033865	nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0048037	cofactor binding	None	Extended
MF	GO:0050662	coenzyme binding	IEA	InterProScan predictions
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0055086	nucleobase-containing small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0072521	purine-containing compound metabolic process	None	Extended
BP	GO:1901135	carbohydrate derivative metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	IEP	Predicted GO
MF	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	IEP	Predicted GO
MF	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IEP	Predicted GO
MF	GO:0004506	squalene monooxygenase activity	IEP	Predicted GO
MF	GO:0004615	phosphomannomutase activity	IEP	Predicted GO
MF	GO:0004619	phosphoglycerate mutase activity	IEP	Predicted GO
MF	GO:0004664	prephenate dehydratase activity	IEP	Predicted GO
MF	GO:0005048	signal sequence binding	IEP	Predicted GO
MF	GO:0005096	GTPase activator activity	IEP	Predicted GO
CC	GO:0005737	cytoplasm	IEP	Predicted GO
BP	GO:0006007	glucose catabolic process	IEP	Predicted GO
BP	GO:0006555	methionine metabolic process	IEP	Predicted GO
BP	GO:0006558	L-phenylalanine metabolic process	IEP	Predicted GO
BP	GO:0006621	protein retention in ER lumen	IEP	Predicted GO
BP	GO:0006629	lipid metabolic process	IEP	Predicted GO
BP	GO:0006810	transport	IEP	Predicted GO
MF	GO:0008047	enzyme activator activity	IEP	Predicted GO
BP	GO:0008272	sulfate transport	IEP	Predicted GO
BP	GO:0009058	biosynthetic process	IEP	Predicted GO
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009094	L-phenylalanine biosynthetic process	IEP	Predicted GO
BP	GO:0009095	aromatic amino acid family biosynthetic process, prephenate pathway	IEP	Predicted GO
BP	GO:0009225	nucleotide-sugar metabolic process	IEP	Predicted GO
BP	GO:0009226	nucleotide-sugar biosynthetic process	IEP	Predicted GO
BP	GO:0009298	GDP-mannose biosynthetic process	IEP	Predicted GO
MF	GO:0015116	sulfate transmembrane transporter activity	IEP	Predicted GO
CC	GO:0016021	integral component of membrane	IEP	Predicted GO
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	IEP	Predicted GO
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEP	Predicted GO
MF	GO:0016779	nucleotidyltransferase activity	IEP	Predicted GO
MF	GO:0016866	intramolecular transferase activity	IEP	Predicted GO
MF	GO:0016868	intramolecular transferase activity, phosphotransferases	IEP	Predicted GO
BP	GO:0019320	hexose catabolic process	IEP	Predicted GO
BP	GO:0019673	GDP-mannose metabolic process	IEP	Predicted GO
MF	GO:0030145	manganese ion binding	IEP	Predicted GO
MF	GO:0030234	enzyme regulator activity	IEP	Predicted GO
MF	GO:0030695	GTPase regulator activity	IEP	Predicted GO
CC	GO:0031224	intrinsic component of membrane	IEP	Predicted GO
BP	GO:0032507	maintenance of protein location in cell	IEP	Predicted GO
MF	GO:0033218	amide binding	IEP	Predicted GO
BP	GO:0035437	maintenance of protein localization in endoplasmic reticulum	IEP	Predicted GO
MF	GO:0042277	peptide binding	IEP	Predicted GO
CC	GO:0043190	ATP-binding cassette (ABC) transporter complex	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
BP	GO:0045185	maintenance of protein location	IEP	Predicted GO
BP	GO:0046365	monosaccharide catabolic process	IEP	Predicted GO
MF	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	IEP	Predicted GO
MF	GO:0046923	ER retention sequence binding	IEP	Predicted GO
BP	GO:0051179	localization	IEP	Predicted GO
BP	GO:0051234	establishment of localization	IEP	Predicted GO
BP	GO:0051235	maintenance of location	IEP	Predicted GO
BP	GO:0051651	maintenance of location in cell	IEP	Predicted GO
BP	GO:0055085	transmembrane transport	IEP	Predicted GO
MF	GO:0060589	nucleoside-triphosphatase regulator activity	IEP	Predicted GO
BP	GO:0072348	sulfur compound transport	IEP	Predicted GO
BP	GO:0072595	maintenance of protein localization in organelle	IEP	Predicted GO
CC	GO:0098533	ATPase dependent transmembrane transport complex	IEP	Predicted GO
MF	GO:0098772	molecular function regulator	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
MF	GO:1901682	sulfur compound transmembrane transporter activity	IEP	Predicted GO
BP	GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	IEP	Predicted GO
BP	GO:1902223	erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process	IEP	Predicted GO
CC	GO:1902495	transmembrane transporter complex	IEP	Predicted GO
CC	GO:1904949	ATPase complex	IEP	Predicted GO
CC	GO:1990351	transporter complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR002202	HMG_CoA_Rdtase	153	528

External Links

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177513

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation