PSME_00000392-RA

Description : (at3g56240 : 120.0) CCH protein belongs to a family of eukaryotic proteins that participate in intracellular copper homeostasis by delivering this metal to the secretory pathway; mainly located along the vascular bundles of senescing leaves and petioles as well as in stem sieve elements; hypothesized to have a role in copper mobilization from decaying organs towards reproductive structures, as a result of metalloprotein breakdown. The plant-specific C-terminal domain of the CCH protein forms amyloid-like fibrils in vitro.; copper chaperone (CCH); FUNCTIONS IN: copper chaperone activity; INVOLVED IN: in 6 processes; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: homolog of anti-oxidant 1 (TAIR:AT1G66240.1); Has 2051 Blast hits to 1937 proteins in 366 species: Archae - 10; Bacteria - 382; Metazoa - 168; Fungi - 207; Plants - 1221; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink). & (reliability: 240.0) & (original description: no original description)

Gene families : OG_42_0000041 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000041_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00000392-RA
Cluster	HCCA clusters: Cluster_133

Target	Alias	Description	ECC score	Gene Family Method
109953	No alias	homolog of anti-oxidant 1	0.03	Orthogroups_2024-Update
HORVU2Hr1G029270.2	No alias	Unknown function	0.02	Orthogroups_2024-Update
Solyc01g111600	No alias	Heavy metal transport/detoxification superfamily protein...	0.03	Orthogroups_2024-Update
Sopen01g053640	No alias	Heavy-metal-associated domain	0.03	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006810	transport	None	Extended
BP	GO:0006811	ion transport	None	Extended
BP	GO:0006812	cation transport	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0030001	metal ion transport	IEA	InterProScan predictions
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
MF	GO:0046872	metal ion binding	IEA	InterProScan predictions
BP	GO:0051179	localization	None	Extended
BP	GO:0051234	establishment of localization	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000062	fatty-acyl-CoA binding	IEP	Predicted GO
MF	GO:0003735	structural constituent of ribosome	IEP	Predicted GO
MF	GO:0003954	NADH dehydrogenase activity	IEP	Predicted GO
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0004867	serine-type endopeptidase inhibitor activity	IEP	Predicted GO
MF	GO:0005198	structural molecule activity	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
CC	GO:0005739	mitochondrion	IEP	Predicted GO
CC	GO:0005750	mitochondrial respiratory chain complex III	IEP	Predicted GO
CC	GO:0005840	ribosome	IEP	Predicted GO
BP	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	IEP	Predicted GO
BP	GO:0006412	translation	IEP	Predicted GO
BP	GO:0006518	peptide metabolic process	IEP	Predicted GO
MF	GO:0008137	NADH dehydrogenase (ubiquinone) activity	IEP	Predicted GO
BP	GO:0009059	macromolecule biosynthetic process	IEP	Predicted GO
CC	GO:0009521	photosystem	IEP	Predicted GO
CC	GO:0009522	photosystem I	IEP	Predicted GO
CC	GO:0009523	photosystem II	IEP	Predicted GO
BP	GO:0009611	response to wounding	IEP	Predicted GO
CC	GO:0009654	photosystem II oxygen evolving complex	IEP	Predicted GO
BP	GO:0015979	photosynthesis	IEP	Predicted GO
BP	GO:0016125	sterol metabolic process	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
BP	GO:0016197	endosomal transport	IEP	Predicted GO
BP	GO:0016226	iron-sulfur cluster assembly	IEP	Predicted GO
BP	GO:0016482	cytosolic transport	IEP	Predicted GO
MF	GO:0016651	oxidoreductase activity, acting on NAD(P)H	IEP	Predicted GO
MF	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEP	Predicted GO
MF	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	IEP	Predicted GO
CC	GO:0019898	extrinsic component of membrane	IEP	Predicted GO
BP	GO:0022607	cellular component assembly	IEP	Predicted GO
BP	GO:0022904	respiratory electron transport chain	IEP	Predicted GO
MF	GO:0030414	peptidase inhibitor activity	IEP	Predicted GO
CC	GO:0030880	RNA polymerase complex	IEP	Predicted GO
CC	GO:0030906	retromer, cargo-selective complex	IEP	Predicted GO
CC	GO:0031082	BLOC complex	IEP	Predicted GO
CC	GO:0031083	BLOC-1 complex	IEP	Predicted GO
BP	GO:0031163	metallo-sulfur cluster assembly	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
MF	GO:0033218	amide binding	IEP	Predicted GO
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:0042147	retrograde transport, endosome to Golgi	IEP	Predicted GO
BP	GO:0043043	peptide biosynthetic process	IEP	Predicted GO
CC	GO:0043226	organelle	IEP	Predicted GO
CC	GO:0043228	non-membrane-bounded organelle	IEP	Predicted GO
CC	GO:0043229	intracellular organelle	IEP	Predicted GO
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Predicted GO
BP	GO:0043603	cellular amide metabolic process	IEP	Predicted GO
BP	GO:0043604	amide biosynthetic process	IEP	Predicted GO
BP	GO:0044249	cellular biosynthetic process	IEP	Predicted GO
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Predicted GO
CC	GO:0044424	intracellular part	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
CC	GO:0044436	thylakoid part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044445	cytosolic part	IEP	Predicted GO
CC	GO:0044455	mitochondrial membrane part	IEP	Predicted GO
CC	GO:0044464	cell part	IEP	Predicted GO
CC	GO:0045275	respiratory chain complex III	IEP	Predicted GO
MF	GO:0047750	cholestenol delta-isomerase activity	IEP	Predicted GO
MF	GO:0050136	NADH dehydrogenase (quinone) activity	IEP	Predicted GO
MF	GO:0061134	peptidase regulator activity	IEP	Predicted GO
MF	GO:0061135	endopeptidase regulator activity	IEP	Predicted GO
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	IEP	Predicted GO
CC	GO:0070069	cytochrome complex	IEP	Predicted GO
BP	GO:0070070	proton-transporting V-type ATPase complex assembly	IEP	Predicted GO
BP	GO:0070071	proton-transporting two-sector ATPase complex assembly	IEP	Predicted GO
BP	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
CC	GO:0098798	mitochondrial protein complex	IEP	Predicted GO
CC	GO:0098800	inner mitochondrial membrane protein complex	IEP	Predicted GO
CC	GO:0098803	respiratory chain complex	IEP	Predicted GO
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Predicted GO
MF	GO:1901567	fatty acid derivative binding	IEP	Predicted GO
BP	GO:1901576	organic substance biosynthetic process	IEP	Predicted GO
BP	GO:1901615	organic hydroxy compound metabolic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
CC	GO:1902494	catalytic complex	IEP	Predicted GO
CC	GO:1990204	oxidoreductase complex	IEP	Predicted GO
CC	GO:1990904	ribonucleoprotein complex	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006121	HMA_dom	7	63

External Links

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PSME_00000392-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation