PSME_00003087-RA

Description : (at5g17920 : 1128.0) Encodes a cytosolic cobalamin-independent methionine synthase, involved in methionine regeneration via the activated methyl cycle (SAM cycle). The protein undergoes thiolation following treatment with the oxidant tert-butylhydroperoxide.; COBALAMIN-INDEPENDENT METHIONINE SYNTHASE (ATCIMS); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to zinc ion, response to salt stress, methionine biosynthetic process; LOCATED IN: in 6 components; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: methionine synthase 2 (TAIR:AT3G03780.3); Has 4442 Blast hits to 4434 proteins in 1682 species: Archae - 183; Bacteria - 3246; Metazoa - 14; Fungi - 206; Plants - 251; Viruses - 2; Other Eukaryotes - 540 (source: NCBI BLink). & (q42699|mete_catro : 1123.0) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Vitamin-B12-independent methionine synthase isozyme) (Cobalamin-independent methionine synthase isozyme) - Catharanthus roseus (Rosy periwinkle) (Madag & (reliability: 2256.0) & (original description: no original description)

Gene families : OG_42_0002037 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0002037_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00003087-RA
Cluster	HCCA clusters: Cluster_5

Target	Alias	Description	ECC score	Gene Family Method
171028	No alias	Cobalamin-independent synthase family protein	0.02	Orthogroups_2024-Update
A4A49_56331	No alias	5-methyltetrahydropteroyltriglutamate--homocysteine...	0.05	Orthogroups_2024-Update
A4A49_56364	No alias	5-methyltetrahydropteroyltriglutamate--homocysteine...	0.02	Orthogroups_2024-Update
Brara.B00738.1	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.04	Orthogroups_2024-Update
Brara.C00790.1	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.04	Orthogroups_2024-Update
Cre03.g180750	No alias	methionine synthase 3	0.02	Orthogroups_2024-Update
Glyma.16G038300	No alias	Cobalamin-independent synthase family protein	0.04	Orthogroups_2024-Update
Glyma.19G114500	No alias	Cobalamin-independent synthase family protein	0.05	Orthogroups_2024-Update
HORVU5Hr1G006780.7	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.03	Orthogroups_2024-Update
Potri.004G190900	No alias	Cobalamin-independent synthase family protein	0.03	Orthogroups_2024-Update
Potri.019G038200	No alias	Cobalamin-independent synthase family protein	0.06	Orthogroups_2024-Update
Seita.9G151200.1	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.03	Orthogroups_2024-Update
Sobic.001G148900.2	No alias	methyl-tetrahydrofolate-dependent methionine synthase &...	0.03	Orthogroups_2024-Update
Solyc10g081510	No alias	ethylene-responsive methionine synthase	0.02	Orthogroups_2024-Update
Sopen10g032020	No alias	Cobalamin-independent synthase, Catalytic domain	0.04	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	None	Extended
BP	GO:0000097	sulfur amino acid biosynthetic process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006555	methionine metabolic process	None	Extended
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
MF	GO:0008172	S-methyltransferase activity	None	Extended
MF	GO:0008270	zinc ion binding	IEA	InterProScan predictions
BP	GO:0008652	cellular amino acid biosynthetic process	IEA	InterProScan predictions
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009066	aspartate family amino acid metabolic process	None	Extended
BP	GO:0009067	aspartate family amino acid biosynthetic process	None	Extended
BP	GO:0009086	methionine biosynthetic process	IEA	InterProScan predictions
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044272	sulfur compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901605	alpha-amino acid metabolic process	None	Extended
BP	GO:1901607	alpha-amino acid biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0003700	DNA-binding transcription factor activity	IEP	Predicted GO
MF	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	IEP	Predicted GO
MF	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	IEP	Predicted GO
MF	GO:0004107	chorismate synthase activity	IEP	Predicted GO
MF	GO:0004332	fructose-bisphosphate aldolase activity	IEP	Predicted GO
MF	GO:0004478	methionine adenosyltransferase activity	IEP	Predicted GO
MF	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IEP	Predicted GO
MF	GO:0004664	prephenate dehydratase activity	IEP	Predicted GO
MF	GO:0004743	pyruvate kinase activity	IEP	Predicted GO
MF	GO:0004888	transmembrane signaling receptor activity	IEP	Predicted GO
MF	GO:0004970	ionotropic glutamate receptor activity	IEP	Predicted GO
MF	GO:0005086	ARF guanyl-nucleotide exchange factor activity	IEP	Predicted GO
MF	GO:0005215	transporter activity	IEP	Predicted GO
MF	GO:0005216	ion channel activity	IEP	Predicted GO
MF	GO:0005230	extracellular ligand-gated ion channel activity	IEP	Predicted GO
BP	GO:0006090	pyruvate metabolic process	IEP	Predicted GO
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Predicted GO
BP	GO:0006096	glycolytic process	IEP	Predicted GO
BP	GO:0006164	purine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Predicted GO
BP	GO:0006536	glutamate metabolic process	IEP	Predicted GO
BP	GO:0006537	glutamate biosynthetic process	IEP	Predicted GO
BP	GO:0006556	S-adenosylmethionine biosynthetic process	IEP	Predicted GO
BP	GO:0006558	L-phenylalanine metabolic process	IEP	Predicted GO
BP	GO:0006605	protein targeting	IEP	Predicted GO
BP	GO:0006612	protein targeting to membrane	IEP	Predicted GO
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Predicted GO
BP	GO:0006732	coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006733	oxidoreduction coenzyme metabolic process	IEP	Predicted GO
BP	GO:0006754	ATP biosynthetic process	IEP	Predicted GO
BP	GO:0006757	ATP generation from ADP	IEP	Predicted GO
MF	GO:0008066	glutamate receptor activity	IEP	Predicted GO
MF	GO:0008312	7S RNA binding	IEP	Predicted GO
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	Predicted GO
BP	GO:0009073	aromatic amino acid family biosynthetic process	IEP	Predicted GO
BP	GO:0009094	L-phenylalanine biosynthetic process	IEP	Predicted GO
BP	GO:0009108	coenzyme biosynthetic process	IEP	Predicted GO
BP	GO:0009123	nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009124	nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009126	purine nucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009141	nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009142	nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009144	purine nucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009145	purine nucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009152	purine ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009161	ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009166	nucleotide catabolic process	IEP	Predicted GO
BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	IEP	Predicted GO
BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Predicted GO
BP	GO:0009199	ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009201	ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009205	purine ribonucleoside triphosphate metabolic process	IEP	Predicted GO
BP	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	IEP	Predicted GO
BP	GO:0009260	ribonucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0009966	regulation of signal transduction	IEP	Predicted GO
BP	GO:0010215	cellulose microfibril organization	IEP	Predicted GO
BP	GO:0010646	regulation of cell communication	IEP	Predicted GO
MF	GO:0015075	ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015098	molybdate ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015267	channel activity	IEP	Predicted GO
MF	GO:0015276	ligand-gated ion channel activity	IEP	Predicted GO
MF	GO:0015318	inorganic molecular entity transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015689	molybdate ion transport	IEP	Predicted GO
MF	GO:0015930	glutamate synthase activity	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
BP	GO:0016049	cell growth	IEP	Predicted GO
BP	GO:0016052	carbohydrate catabolic process	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Predicted GO
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Predicted GO
MF	GO:0016829	lyase activity	IEP	Predicted GO
MF	GO:0016832	aldehyde-lyase activity	IEP	Predicted GO
MF	GO:0016887	ATPase activity	IEP	Predicted GO
BP	GO:0017144	drug metabolic process	IEP	Predicted GO
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Predicted GO
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Predicted GO
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Predicted GO
BP	GO:0019439	aromatic compound catabolic process	IEP	Predicted GO
MF	GO:0022803	passive transmembrane transporter activity	IEP	Predicted GO
MF	GO:0022824	transmitter-gated ion channel activity	IEP	Predicted GO
MF	GO:0022834	ligand-gated channel activity	IEP	Predicted GO
MF	GO:0022835	transmitter-gated channel activity	IEP	Predicted GO
MF	GO:0022836	gated channel activity	IEP	Predicted GO
MF	GO:0022838	substrate-specific channel activity	IEP	Predicted GO
MF	GO:0022839	ion gated channel activity	IEP	Predicted GO
MF	GO:0022857	transmembrane transporter activity	IEP	Predicted GO
BP	GO:0023051	regulation of signaling	IEP	Predicted GO
BP	GO:0030198	extracellular matrix organization	IEP	Predicted GO
MF	GO:0030594	neurotransmitter receptor activity	IEP	Predicted GO
MF	GO:0030955	potassium ion binding	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
MF	GO:0031420	alkali metal ion binding	IEP	Predicted GO
BP	GO:0032012	regulation of ARF protein signal transduction	IEP	Predicted GO
BP	GO:0032787	monocarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	IEP	Predicted GO
BP	GO:0034655	nucleobase-containing compound catabolic process	IEP	Predicted GO
MF	GO:0038023	signaling receptor activity	IEP	Predicted GO
BP	GO:0040007	growth	IEP	Predicted GO
BP	GO:0042866	pyruvate biosynthetic process	IEP	Predicted GO
BP	GO:0043062	extracellular structure organization	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0044270	cellular nitrogen compound catabolic process	IEP	Predicted GO
BP	GO:0045047	protein targeting to ER	IEP	Predicted GO
BP	GO:0046031	ADP metabolic process	IEP	Predicted GO
BP	GO:0046034	ATP metabolic process	IEP	Predicted GO
BP	GO:0046390	ribose phosphate biosynthetic process	IEP	Predicted GO
BP	GO:0046434	organophosphate catabolic process	IEP	Predicted GO
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Predicted GO
BP	GO:0046500	S-adenosylmethionine metabolic process	IEP	Predicted GO
BP	GO:0046578	regulation of Ras protein signal transduction	IEP	Predicted GO
BP	GO:0046700	heterocycle catabolic process	IEP	Predicted GO
BP	GO:0046939	nucleotide phosphorylation	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
CC	GO:0048500	signal recognition particle	IEP	Predicted GO
BP	GO:0048583	regulation of response to stimulus	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051056	regulation of small GTPase mediated signal transduction	IEP	Predicted GO
BP	GO:0051186	cofactor metabolic process	IEP	Predicted GO
BP	GO:0051188	cofactor biosynthetic process	IEP	Predicted GO
MF	GO:0051287	NAD binding	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
MF	GO:0060089	molecular transducer activity	IEP	Predicted GO
MF	GO:0070569	uridylyltransferase activity	IEP	Predicted GO
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Predicted GO
BP	GO:0072330	monocarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Predicted GO
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Predicted GO
BP	GO:0072657	protein localization to membrane	IEP	Predicted GO
BP	GO:0090150	establishment of protein localization to membrane	IEP	Predicted GO
MF	GO:0140110	transcription regulator activity	IEP	Predicted GO
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Predicted GO
BP	GO:1901292	nucleoside phosphate catabolic process	IEP	Predicted GO
BP	GO:1901361	organic cyclic compound catabolic process	IEP	Predicted GO
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
BP	GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	IEP	Predicted GO
BP	GO:1902223	erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:1902531	regulation of intracellular signal transduction	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013215	Cbl-indep_Met_Synth_N	92	291
IPR013215	Cbl-indep_Met_Synth_N	13	89
IPR002629	Met_Synth_C/arc	407	730

External Links

No external refs found!

PSME_00003087-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation