PSME_00003464-RA

Description : (at1g08260 : 1385.0) Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells.; TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink). & (reliability: 2770.0) & (original description: no original description)

Gene families : OG_42_0003443 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0003443_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00003464-RA
Cluster	HCCA clusters: Cluster_95

Target	Alias	Description	ECC score	Gene Family Method
Glyma.12G087000	No alias	DNA polymerase epsilon catalytic subunit	0.02	Orthogroups_2024-Update
Solyc11g067110	No alias	DNA polymerase epsilon catalytic subunit (AHRD V3.3 -...	0.02	Orthogroups_2024-Update
Solyc11g067120	No alias	No description available	0.03	Orthogroups_2024-Update
Solyc11g067130	No alias	No description available	0.02	Orthogroups_2024-Update
Solyc11g067140	No alias	DNA polymerase epsilon catalytic subunit A (AHRD V3.3...	0.02	Orthogroups_2024-Update
Sopen11g026820	No alias	Domain of unknown function (DUF1744)	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003887	DNA-directed DNA polymerase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008270	zinc ion binding	IEA	InterProScan predictions
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016779	nucleotidyltransferase activity	None	Extended
MF	GO:0034061	DNA polymerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
BP	GO:0001510	RNA methylation	IEP	Predicted GO
MF	GO:0004175	endopeptidase activity	IEP	Predicted GO
MF	GO:0004252	serine-type endopeptidase activity	IEP	Predicted GO
CC	GO:0005667	transcription factor complex	IEP	Predicted GO
BP	GO:0005991	trehalose metabolic process	IEP	Predicted GO
BP	GO:0005992	trehalose biosynthetic process	IEP	Predicted GO
BP	GO:0006396	RNA processing	IEP	Predicted GO
BP	GO:0006400	tRNA modification	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006855	drug transmembrane transport	IEP	Predicted GO
BP	GO:0008033	tRNA processing	IEP	Predicted GO
MF	GO:0008081	phosphoric diester hydrolase activity	IEP	Predicted GO
MF	GO:0008173	RNA methyltransferase activity	IEP	Predicted GO
MF	GO:0008175	tRNA methyltransferase activity	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008236	serine-type peptidase activity	IEP	Predicted GO
MF	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	IEP	Predicted GO
BP	GO:0009312	oligosaccharide biosynthetic process	IEP	Predicted GO
BP	GO:0009451	RNA modification	IEP	Predicted GO
CC	GO:0009521	photosystem	IEP	Predicted GO
CC	GO:0009522	photosystem I	IEP	Predicted GO
CC	GO:0009538	photosystem I reaction center	IEP	Predicted GO
MF	GO:0015238	drug transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015291	secondary active transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015297	antiporter activity	IEP	Predicted GO
BP	GO:0015893	drug transport	IEP	Predicted GO
BP	GO:0015979	photosynthesis	IEP	Predicted GO
MF	GO:0016426	tRNA (adenine) methyltransferase activity	IEP	Predicted GO
MF	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IEP	Predicted GO
MF	GO:0017171	serine hydrolase activity	IEP	Predicted GO
BP	GO:0030488	tRNA methylation	IEP	Predicted GO
CC	GO:0030532	small nuclear ribonucleoprotein complex	IEP	Predicted GO
CC	GO:0031515	tRNA (m1A) methyltransferase complex	IEP	Predicted GO
BP	GO:0032259	methylation	IEP	Predicted GO
MF	GO:0032553	ribonucleotide binding	IEP	Predicted GO
CC	GO:0032991	protein-containing complex	IEP	Predicted GO
CC	GO:0034708	methyltransferase complex	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043414	macromolecule methylation	IEP	Predicted GO
CC	GO:0043527	tRNA methyltransferase complex	IEP	Predicted GO
CC	GO:0044436	thylakoid part	IEP	Predicted GO
BP	GO:0046351	disaccharide biosynthetic process	IEP	Predicted GO
CC	GO:0046540	U4/U6 x U5 tri-snRNP complex	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
MF	GO:0070569	uridylyltransferase activity	IEP	Predicted GO
MF	GO:0097367	carbohydrate derivative binding	IEP	Predicted GO
CC	GO:0097525	spliceosomal snRNP complex	IEP	Predicted GO
CC	GO:0097526	spliceosomal tri-snRNP complex	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
CC	GO:0120114	Sm-like protein family complex	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR013697	DNA_pol_e_suA_C	698	1066

External Links

No external refs found!

PSME_00003464-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation