PSME_00003755-RA

Description : (at3g24495 : 345.0) encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH7 exhibit moderate affinity for a (T/G) substrate and weak binding of (+T), suggesting MSH2*MSH7 may be specialized for lesions/base mispairs not tested or for (T/G) mispairs in special contexts.; MUTS homolog 7 (MSH7); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 17871 Blast hits to 13835 proteins in 2667 species: Archae - 197; Bacteria - 11731; Metazoa - 1028; Fungi - 1274; Plants - 566; Viruses - 3; Other Eukaryotes - 3072 (source: NCBI BLink). & (q9xgc9|msh2_maize : 150.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 690.0) & (original description: no original description)

Gene families : OG_42_0001047 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001047_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00003755-RA
Cluster	HCCA clusters: Cluster_99

Target	Alias	Description	ECC score	Gene Family Method
Cre05.g235750	No alias	MUTS homolog 6	0.01	Orthogroups_2024-Update
PSME_00015196-RA	No alias	(at3g24495 : 159.0) encodes a DNA mismatch repair...	0.05	Orthogroups_2024-Update
PSME_00019253-RA	No alias	(at3g24495 : 152.0) encodes a DNA mismatch repair...	0.04	Orthogroups_2024-Update
PSME_00032571-RA	No alias	(at3g24495 : 167.0) encodes a DNA mismatch repair...	0.05	Orthogroups_2024-Update
PSME_00048248-RA	No alias	(at3g24495 : 111.0) encodes a DNA mismatch repair...	0.04	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	InterProScan predictions
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	InterProScan predictions
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0004126	cytidine deaminase activity	IEP	Predicted GO
MF	GO:0004518	nuclease activity	IEP	Predicted GO
MF	GO:0004519	endonuclease activity	IEP	Predicted GO
MF	GO:0004521	endoribonuclease activity	IEP	Predicted GO
MF	GO:0004523	RNA-DNA hybrid ribonuclease activity	IEP	Predicted GO
MF	GO:0004540	ribonuclease activity	IEP	Predicted GO
BP	GO:0006213	pyrimidine nucleoside metabolic process	IEP	Predicted GO
BP	GO:0006216	cytidine catabolic process	IEP	Predicted GO
BP	GO:0009164	nucleoside catabolic process	IEP	Predicted GO
BP	GO:0009972	cytidine deamination	IEP	Predicted GO
MF	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IEP	Predicted GO
MF	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Predicted GO
CC	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	IEP	Predicted GO
BP	GO:0034656	nucleobase-containing small molecule catabolic process	IEP	Predicted GO
BP	GO:0042454	ribonucleoside catabolic process	IEP	Predicted GO
CC	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	IEP	Predicted GO
BP	GO:0046087	cytidine metabolic process	IEP	Predicted GO
BP	GO:0046131	pyrimidine ribonucleoside metabolic process	IEP	Predicted GO
BP	GO:0046133	pyrimidine ribonucleoside catabolic process	IEP	Predicted GO
BP	GO:0046135	pyrimidine nucleoside catabolic process	IEP	Predicted GO
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Predicted GO
BP	GO:0072529	pyrimidine-containing compound catabolic process	IEP	Predicted GO
BP	GO:1901658	glycosyl compound catabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000432	DNA_mismatch_repair_MutS_C	116	333

External Links

No external refs found!

PSME_00003755-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation