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PSME_00005538-RA


Description : (p35063|h2ax_picab : 158.0) Histone H2AX - Picea abies (Norway spruce) (Picea excelsa) & (at1g54690 : 154.0) Encodes HTA3, a histone H2A protein. H2AX is a meiosis-specific isoform of histone H2A. Upon DSB formation, rapid accumulation of phosphorylated H2AX (γ-H2AX) occurs around the break site. H2AX foci accumulate in early G2. Immunolocalization studies in spread preparations of wild-type meiocytes at G2/early leptotene revealed the accumulation of numerous rather diffuse γ-H2AX foci throughout the chromatin. However, their accumulation is not contemporaneous with that of AtSPO11-1. At 3 h post-S, no γ-H2AX foci are detected. During the 3- to 5-h window when AtSPO11-1 foci rapidly disappear, there is an equally swift accumulation of γ-H2AX to a maximum of >50 diffuse foci. The level of γH2AX then remains constant for a further 13 h before undergoing a gradual decrease to 10ñ20 foci in the 18- to 24-h post-S period. By 30 h the foci have disappeared from the chromatin.; gamma histone variant H2AX (GAMMA-H2AX); FUNCTIONS IN: DNA binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2A (InterPro:IPR002119), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: Histone superfamily protein (TAIR:AT1G08880.1); Has 3932 Blast hits to 3927 proteins in 364 species: Archae - 0; Bacteria - 0; Metazoa - 2549; Fungi - 335; Plants - 612; Viruses - 4; Other Eukaryotes - 432 (source: NCBI BLink). & (reliability: 308.0) & (original description: no original description)


Gene families : OG_42_0000138 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000138_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood Pseudotsuga release: PSME_00005538-RA
Cluster HCCA clusters: Cluster_187

Target Alias Description ECC score Gene Family Method Actions
170948 No alias Histone superfamily protein 0.02 Orthogroups_2024-Update
HORVU6Hr1G021160.1 No alias histone *(H2A) 0.02 Orthogroups_2024-Update
HORVU7Hr1G100400.2 No alias histone *(H2A) 0.08 Orthogroups_2024-Update
LOC_Os05g38640 No alias Core histone H2A/H2B/H3/H4 domain containing protein,... 0.01 Orthogroups_2024-Update
LOC_Os07g36140 No alias core histone H2A/H2B/H3/H4, putative, expressed 0.02 Orthogroups_2024-Update
Sobic.002G276000.1 No alias histone *(H2A) 0.02 Orthogroups_2024-Update
Sopen09g005140 No alias Core histone H2A/H2B/H3/H4 0.02 Orthogroups_2024-Update
Sopen09g029130 No alias Core histone H2A/H2B/H3/H4 0.03 Orthogroups_2024-Update

Type GO Term Name Evidence Source
CC GO:0000786 nucleosome IEA InterProScan predictions
MF GO:0003677 DNA binding IEA InterProScan predictions
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Type GO Term Name Evidence Source
BP GO:0008037 cell recognition IEP Predicted GO
MF GO:0008171 O-methyltransferase activity IEP Predicted GO
BP GO:0022414 reproductive process IEP Predicted GO
BP GO:0048544 recognition of pollen IEP Predicted GO
InterPro domains Description Start Stop
IPR007125 Histone_H2A/H2B/H3 14 93
IPR032454 Histone_H2A_C 96 129
No external refs found!