Description : (at1g48050 : 87.8) Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.; KU80; FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), Ku, C-terminal (InterPro:IPR014893); Has 786 Blast hits to 750 proteins in 217 species: Archae - 0; Bacteria - 40; Metazoa - 246; Fungi - 345; Plants - 62; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink). & (reliability: 175.6) & (original description: no original description)
Gene families : OG_42_0001893 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001893_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00009135-RA | |
Cluster | HCCA clusters: Cluster_97 |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
BP | GO:0000726 | non-recombinational repair | IEP | Predicted GO |
MF | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity | IEP | Predicted GO |
CC | GO:0005643 | nuclear pore | IEP | Predicted GO |
CC | GO:0005956 | protein kinase CK2 complex | IEP | Predicted GO |
BP | GO:0006302 | double-strand break repair | IEP | Predicted GO |
BP | GO:0006303 | double-strand break repair via nonhomologous end joining | IEP | Predicted GO |
MF | GO:0008237 | metallopeptidase activity | IEP | Predicted GO |
BP | GO:0009719 | response to endogenous stimulus | IEP | Predicted GO |
BP | GO:0009725 | response to hormone | IEP | Predicted GO |
BP | GO:0009733 | response to auxin | IEP | Predicted GO |
BP | GO:0010033 | response to organic substance | IEP | Predicted GO |
MF | GO:0016874 | ligase activity | IEP | Predicted GO |
MF | GO:0019207 | kinase regulator activity | IEP | Predicted GO |
MF | GO:0019887 | protein kinase regulator activity | IEP | Predicted GO |
BP | GO:0042126 | nitrate metabolic process | IEP | Predicted GO |
BP | GO:0042128 | nitrate assimilation | IEP | Predicted GO |
BP | GO:0071941 | nitrogen cycle metabolic process | IEP | Predicted GO |
BP | GO:2001057 | reactive nitrogen species metabolic process | IEP | Predicted GO |
InterPro domains | Description | Start | Stop |
---|---|---|---|
IPR005161 | Ku_N | 64 | 163 |
No external refs found! |