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Description : (p28002|comt1_medsa : 427.0) Caffeic acid 3-O-methyltransferase (EC 2.1.1.68) (S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase) (COMT) (CAOMT) - Medicago sativa (Alfalfa) & (at5g54160 : 410.0) A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3Ã-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3Ã-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferase; O-methyltransferase 1 (OMT1); FUNCTIONS IN: myricetin 3'-O-methyltransferase activity, quercetin 3-O-methyltransferase activity, caffeate O-methyltransferase activity; INVOLVED IN: lignin biosynthetic process, flavonol biosynthetic process; LOCATED IN: cytosol, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Plant methyltransferase dimerisation (InterPro:IPR012967), O-methyltransferase, family 2 (InterPro:IPR001077), O-methyltransferase, COMT, eukaryota (InterPro:IPR016461); BEST Arabidopsis thaliana protein match is: O-methyltransferase family protein (TAIR:AT1G77520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 820.0) & (original description: no original description)
Gene families : OG_42_0000016 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000016_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00009784-RA | |
| Cluster | HCCA clusters: Cluster_79 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| 76630 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| A4A49_36761 | No alias | caffeic acid 3-o-methyltransferase 1 | 0.04 | Orthogroups_2024-Update | |
| A4A49_41648 | No alias | trans-resveratrol di-o-methyltransferase | 0.03 | Orthogroups_2024-Update | |
| At1g76790 | No alias | Indole glucosinolate O-methyltransferase 5... | 0.02 | Orthogroups_2024-Update | |
| At3g53140 | No alias | AT3g53140/T4D2_70 [Source:UniProtKB/TrEMBL;Acc:Q9SCP7] | 0.03 | Orthogroups_2024-Update | |
| At5g53810 | No alias | Caffeic acid 3-O-methyltransferase-like protein... | 0.04 | Orthogroups_2024-Update | |
| At5g54160 | No alias | Flavone 3'-O-methyltransferase 1... | 0.02 | Orthogroups_2024-Update | |
| Bradi2g02380 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| Brara.F01512.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.04 | Orthogroups_2024-Update | |
| Brara.H01339.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.04 | Orthogroups_2024-Update | |
| Brara.J00896.1 | No alias | caffeic acid O-methyltransferase *(COMT) & EC_2.1... | 0.02 | Orthogroups_2024-Update | |
| GRMZM2G085924 | No alias | O-methyltransferase family protein | 0.05 | Orthogroups_2024-Update | |
| Glyma.04G227700 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| Glyma.09G281800 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| Glyma.11G256500 | No alias | O-methyltransferase family protein | 0.05 | Orthogroups_2024-Update | |
| Glyma.13G173300 | No alias | O-methyltransferase family protein | 0.04 | Orthogroups_2024-Update | |
| Glyma.20G176100 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| MA_10436313g0010 | No alias | (at4g35160 : 227.0) O-methyltransferase family protein;... | 0.03 | Orthogroups_2024-Update | |
| MA_5226589g0010 | No alias | no hits & (original description: no original description) | 0.02 | Orthogroups_2024-Update | |
| MA_86945g0010 | No alias | (at5g54160 : 94.7) A caffeic acid/5-hydroxyferulic acid... | 0.04 | Orthogroups_2024-Update | |
| PSME_00023722-RA | No alias | (p28002|comt1_medsa : 233.0) Caffeic acid... | 0.03 | Orthogroups_2024-Update | |
| PSME_00035775-RA | No alias | (q8w013|comt1_catro : 165.0) Caffeic acid... | 0.05 | Orthogroups_2024-Update | |
| PSME_00053129-RA | No alias | (q8w013|comt1_catro : 265.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
| Potri.012G006400 | No alias | O-methyltransferase 1 | 0.02 | Orthogroups_2024-Update | |
| Potri.013G136400 | No alias | O-methyltransferase family protein | 0.02 | Orthogroups_2024-Update | |
| Seita.8G093200.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.07 | Orthogroups_2024-Update | |
| Sobic.005G045600.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.03 | Orthogroups_2024-Update | |
| Sobic.005G224400.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.04 | Orthogroups_2024-Update | |
| Sobic.007G074800.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.03 | Orthogroups_2024-Update | |
| Solyc10g047520 | No alias | LOW QUALITY:O-methyltransferase (AHRD V3.3 *-* Q6VMV7_MENPI) | 0.03 | Orthogroups_2024-Update | |
| Solyc12g009110 | No alias | O-methyltransferase, putative (AHRD V3.3 *** B9SUX6_RICCO) | 0.02 | Orthogroups_2024-Update | |
| Sopen10g035230 | No alias | O-methyltransferase | 0.03 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0008171 | O-methyltransferase activity | IEA | InterProScan predictions |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0004650 | polygalacturonase activity | IEP | Predicted GO |
| MF | GO:0004857 | enzyme inhibitor activity | IEP | Predicted GO |
| MF | GO:0015035 | protein disulfide oxidoreductase activity | IEP | Predicted GO |
| MF | GO:0015036 | disulfide oxidoreductase activity | IEP | Predicted GO |
| MF | GO:0016491 | oxidoreductase activity | IEP | Predicted GO |
| MF | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | IEP | Predicted GO |
| MF | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors | IEP | Predicted GO |
| MF | GO:0016903 | oxidoreductase activity, acting on the aldehyde or oxo group of donors | IEP | Predicted GO |
| BP | GO:0019725 | cellular homeostasis | IEP | Predicted GO |
| BP | GO:0042592 | homeostatic process | IEP | Predicted GO |
| BP | GO:0045454 | cell redox homeostasis | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR001077 | O_MeTrfase_2 | 1 | 113 |
| No external refs found! |