PSME_00013307-RA

Description : (p57997|if2c_phavu : 551.0) Translation initiation factor IF-2, chloroplast precursor (PvIF2cp) - Phaseolus vulgaris (Kidney bean) (French bean) & (at1g17220 : 540.0) Encodes a chloroplast localized protein with similarity to translation initiation factor 2. Can complement loss of INFB in E.coli suggesting FUG1 does function as a translation initiation factor in vivo. Identified as a suppressor of the leaf variegation mutant var2-6. Suppression is only seen in hypomorphs as complete loss of function alleles are embryo lethal.; fu-gaeri1 (FUG1); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Translation initiation factor IF-2, N-terminal (InterPro:IPR006847), Small GTP-binding protein (InterPro:IPR005225), Translation elongation factor EFTu/EF1A, domain 2 (InterPro:IPR004161), Translation initiation factor 2 related (InterPro:IPR015760), Initiation factor 2 (InterPro:IPR000178), Protein synthesis factor, GTP-binding (InterPro:IPR000795), Translation elongation/initiation factor/Ribosomal, beta-barrel (InterPro:IPR009000); BEST Arabidopsis thaliana protein match is: Translation initiation factor 2, small GTP-binding protein (TAIR:AT4G11160.1); Has 64472 Blast hits to 64325 proteins in 4737 species: Archae - 1215; Bacteria - 42273; Metazoa - 2198; Fungi - 2344; Plants - 1110; Viruses - 4; Other Eukaryotes - 15328 (source: NCBI BLink). & (reliability: 1080.0) & (original description: no original description)

Gene families : OG_42_0001965 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0001965_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00013307-RA
Cluster	HCCA clusters: Cluster_175

Target	Alias	Description	ECC score	Gene Family Method
At1g17220	No alias	Translation initiation factor IF-2, chloroplastic...	0.03	Orthogroups_2024-Update
Cre07.g341850	No alias	Translation initiation factor 2, small GTP-binding protein	0.01	Orthogroups_2024-Update
Glyma.08G174200	No alias	Translation initiation factor 2, small GTP-binding protein	0.06	Orthogroups_2024-Update
Glyma.15G253000	No alias	Translation initiation factor 2, small GTP-binding protein	0.03	Orthogroups_2024-Update
Glyma.19G224000	No alias	Translation initiation factor 2, small GTP-binding protein	0.03	Orthogroups_2024-Update
LOC_Os05g49970	No alias	translation initiation factor IF-2, chloroplast...	0.04	Orthogroups_2024-Update
MA_93993g0010	No alias	(at1g17220 : 212.0) Encodes a chloroplast localized...	0.03	Orthogroups_2024-Update
Mp3g09840.1	No alias	IF-2 translation initiation factor	0.03	Orthogroups_2024-Update
Potri.001G436300	No alias	Translation initiation factor 2, small GTP-binding protein	0.03	Orthogroups_2024-Update
Pp1s59_148V6	No alias	translation initiation factor if-2	0.03	Orthogroups_2024-Update
Seita.1G380500.1	No alias	translation initiation factor *(IF-2)	0.03	Orthogroups_2024-Update
evm.model.tig00020903.32	No alias	(at4g11160 : 310.0) Translation initiation factor 2,...	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0001882	nucleoside binding	None	Extended
MF	GO:0001883	purine nucleoside binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003924	GTPase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005525	GTP binding	IEA	InterProScan predictions
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0019001	guanyl nucleotide binding	None	Extended
MF	GO:0032549	ribonucleoside binding	None	Extended
MF	GO:0032550	purine ribonucleoside binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032561	guanyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0001505	regulation of neurotransmitter levels	IEP	Predicted GO
MF	GO:0002161	aminoacyl-tRNA editing activity	IEP	Predicted GO
MF	GO:0003723	RNA binding	IEP	Predicted GO
MF	GO:0003746	translation elongation factor activity	IEP	Predicted GO
MF	GO:0004329	formate-tetrahydrofolate ligase activity	IEP	Predicted GO
MF	GO:0004375	glycine dehydrogenase (decarboxylating) activity	IEP	Predicted GO
MF	GO:0004721	phosphoprotein phosphatase activity	IEP	Predicted GO
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Predicted GO
MF	GO:0005524	ATP binding	IEP	Predicted GO
MF	GO:0005534	galactose binding	IEP	Predicted GO
BP	GO:0006082	organic acid metabolic process	IEP	Predicted GO
BP	GO:0006399	tRNA metabolic process	IEP	Predicted GO
BP	GO:0006414	translational elongation	IEP	Predicted GO
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Predicted GO
BP	GO:0006520	cellular amino acid metabolic process	IEP	Predicted GO
BP	GO:0006536	glutamate metabolic process	IEP	Predicted GO
BP	GO:0006537	glutamate biosynthetic process	IEP	Predicted GO
BP	GO:0006544	glycine metabolic process	IEP	Predicted GO
BP	GO:0006546	glycine catabolic process	IEP	Predicted GO
MF	GO:0008097	5S rRNA binding	IEP	Predicted GO
MF	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEP	Predicted GO
MF	GO:0008144	drug binding	IEP	Predicted GO
BP	GO:0009063	cellular amino acid catabolic process	IEP	Predicted GO
BP	GO:0009064	glutamine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009069	serine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009071	serine family amino acid catabolic process	IEP	Predicted GO
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0010629	negative regulation of gene expression	IEP	Predicted GO
MF	GO:0015930	glutamate synthase activity	IEP	Predicted GO
BP	GO:0016054	organic acid catabolic process	IEP	Predicted GO
BP	GO:0016311	dephosphorylation	IEP	Predicted GO
BP	GO:0016458	gene silencing	IEP	Predicted GO
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Predicted GO
MF	GO:0016642	oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	IEP	Predicted GO
MF	GO:0016874	ligase activity	IEP	Predicted GO
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Predicted GO
BP	GO:0019752	carboxylic acid metabolic process	IEP	Predicted GO
MF	GO:0019842	vitamin binding	IEP	Predicted GO
MF	GO:0019843	rRNA binding	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
BP	GO:0031047	gene silencing by RNA	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
BP	GO:0034660	ncRNA metabolic process	IEP	Predicted GO
BP	GO:0042133	neurotransmitter metabolic process	IEP	Predicted GO
BP	GO:0042135	neurotransmitter catabolic process	IEP	Predicted GO
BP	GO:0043038	amino acid activation	IEP	Predicted GO
BP	GO:0043039	tRNA aminoacylation	IEP	Predicted GO
BP	GO:0043436	oxoacid metabolic process	IEP	Predicted GO
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Predicted GO
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Predicted GO
BP	GO:0044281	small molecule metabolic process	IEP	Predicted GO
BP	GO:0046395	carboxylic acid catabolic process	IEP	Predicted GO
MF	GO:0048029	monosaccharide binding	IEP	Predicted GO
MF	GO:0051536	iron-sulfur cluster binding	IEP	Predicted GO
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEP	Predicted GO
MF	GO:0051540	metal cluster binding	IEP	Predicted GO
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Predicted GO
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Predicted GO
BP	GO:1901606	alpha-amino acid catabolic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO
MF	GO:2001070	starch binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR006847	IF2_N	474	523
IPR000795	TF_GTP-bd_dom	557	717

External Links

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PSME_00013307-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation