PSME_00013995-RA

Description : (q9se94|mthr1_maize : 985.0) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20) (ZmMTHFR1) - Zea mays (Maize) & (at3g59970 : 959.0) methylenetetrahydrofolate reductase MTHFR1 mRNA, complete; methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4753 Blast hits to 4742 proteins in 1927 species: Archae - 14; Bacteria - 3601; Metazoa - 134; Fungi - 280; Plants - 73; Viruses - 0; Other Eukaryotes - 651 (source: NCBI BLink). & (reliability: 1918.0) & (original description: no original description)

Gene families : OG_42_0004555 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0004555_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00013995-RA
Cluster	HCCA clusters: Cluster_5

Target	Alias	Description	ECC score	Gene Family Method
A4A49_36255	No alias	putative methylenetetrahydrofolate reductase	0.06	Orthogroups_2024-Update
Bradi1g04140	No alias	methylenetetrahydrofolate reductase 2	0.06	Orthogroups_2024-Update
Glyma.06G325300	No alias	methylenetetrahydrofolate reductase 2	0.05	Orthogroups_2024-Update
Kfl00261_0190	kfl00261_0190_v1.1	(q9se94\|mthr1_maize : 855.0) Methylenetetrahydrofolate...	0.03	Orthogroups_2024-Update
Mp1g29250.1	No alias	5,10-methylene-THF reductase	0.02	Orthogroups_2024-Update
Pp1s535_3V6	No alias	methylenetetrahydrofolate reductase	0.02	Orthogroups_2024-Update
Sobic.001G040100.1	No alias	5,10-methylene-THF reductase & EC_1.5 oxidoreductase...	0.05	Orthogroups_2024-Update
Solyc05g055730	No alias	Methylenetetrahydrofolate reductase (AHRD V3.3 *** K4C2P8_SOLLC)	0.03	Orthogroups_2024-Update
Solyc11g008870	No alias	Methylenetetrahydrofolate reductase (AHRD V3.3 *** K4D5E7_SOLLC)	0.02	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IEA	InterProScan predictions
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006555	methionine metabolic process	IEA	InterProScan predictions
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009066	aspartate family amino acid metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901605	alpha-amino acid metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000097	sulfur amino acid biosynthetic process	IEP	Predicted GO
CC	GO:0000139	Golgi membrane	IEP	Predicted GO
MF	GO:0000155	phosphorelay sensor kinase activity	IEP	Predicted GO
MF	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	IEP	Predicted GO
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEP	Predicted GO
MF	GO:0003924	GTPase activity	IEP	Predicted GO
MF	GO:0004512	inositol-3-phosphate synthase activity	IEP	Predicted GO
MF	GO:0004576	oligosaccharyl transferase activity	IEP	Predicted GO
MF	GO:0004673	protein histidine kinase activity	IEP	Predicted GO
MF	GO:0004674	protein serine/threonine kinase activity	IEP	Predicted GO
MF	GO:0005338	nucleotide-sugar transmembrane transporter activity	IEP	Predicted GO
CC	GO:0005575	cellular_component	IEP	Predicted GO
BP	GO:0006020	inositol metabolic process	IEP	Predicted GO
BP	GO:0006021	inositol biosynthetic process	IEP	Predicted GO
BP	GO:0006066	alcohol metabolic process	IEP	Predicted GO
BP	GO:0006486	protein glycosylation	IEP	Predicted GO
BP	GO:0006487	protein N-linked glycosylation	IEP	Predicted GO
BP	GO:0006886	intracellular protein transport	IEP	Predicted GO
BP	GO:0006888	ER to Golgi vesicle-mediated transport	IEP	Predicted GO
BP	GO:0008104	protein localization	IEP	Predicted GO
MF	GO:0008172	S-methyltransferase activity	IEP	Predicted GO
CC	GO:0008250	oligosaccharyltransferase complex	IEP	Predicted GO
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009086	methionine biosynthetic process	IEP	Predicted GO
MF	GO:0009916	alternative oxidase activity	IEP	Predicted GO
BP	GO:0010215	cellulose microfibril organization	IEP	Predicted GO
MF	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEP	Predicted GO
MF	GO:0015020	glucuronosyltransferase activity	IEP	Predicted GO
BP	GO:0015031	protein transport	IEP	Predicted GO
MF	GO:0015098	molybdate ion transmembrane transporter activity	IEP	Predicted GO
MF	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	IEP	Predicted GO
BP	GO:0015689	molybdate ion transport	IEP	Predicted GO
BP	GO:0015780	nucleotide-sugar transmembrane transport	IEP	Predicted GO
BP	GO:0015833	peptide transport	IEP	Predicted GO
CC	GO:0016020	membrane	IEP	Predicted GO
CC	GO:0016021	integral component of membrane	IEP	Predicted GO
BP	GO:0016049	cell growth	IEP	Predicted GO
BP	GO:0016192	vesicle-mediated transport	IEP	Predicted GO
MF	GO:0016462	pyrophosphatase activity	IEP	Predicted GO
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Predicted GO
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	IEP	Predicted GO
MF	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	IEP	Predicted GO
MF	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	IEP	Predicted GO
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Predicted GO
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Predicted GO
MF	GO:0016872	intramolecular lyase activity	IEP	Predicted GO
MF	GO:0016887	ATPase activity	IEP	Predicted GO
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Predicted GO
BP	GO:0019751	polyol metabolic process	IEP	Predicted GO
CC	GO:0030117	membrane coat	IEP	Predicted GO
CC	GO:0030120	vesicle coat	IEP	Predicted GO
CC	GO:0030126	COPI vesicle coat	IEP	Predicted GO
CC	GO:0030127	COPII vesicle coat	IEP	Predicted GO
CC	GO:0030176	integral component of endoplasmic reticulum membrane	IEP	Predicted GO
BP	GO:0030198	extracellular matrix organization	IEP	Predicted GO
MF	GO:0030976	thiamine pyrophosphate binding	IEP	Predicted GO
MF	GO:0031072	heat shock protein binding	IEP	Predicted GO
CC	GO:0031224	intrinsic component of membrane	IEP	Predicted GO
CC	GO:0031225	anchored component of membrane	IEP	Predicted GO
CC	GO:0031227	intrinsic component of endoplasmic reticulum membrane	IEP	Predicted GO
BP	GO:0033036	macromolecule localization	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0040007	growth	IEP	Predicted GO
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	IEP	Predicted GO
BP	GO:0042886	amide transport	IEP	Predicted GO
BP	GO:0043062	extracellular structure organization	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043413	macromolecule glycosylation	IEP	Predicted GO
BP	GO:0044272	sulfur compound biosynthetic process	IEP	Predicted GO
BP	GO:0044283	small molecule biosynthetic process	IEP	Predicted GO
CC	GO:0044422	organelle part	IEP	Predicted GO
CC	GO:0044425	membrane part	IEP	Predicted GO
CC	GO:0044431	Golgi apparatus part	IEP	Predicted GO
CC	GO:0044432	endoplasmic reticulum part	IEP	Predicted GO
CC	GO:0044433	cytoplasmic vesicle part	IEP	Predicted GO
CC	GO:0044444	cytoplasmic part	IEP	Predicted GO
CC	GO:0044446	intracellular organelle part	IEP	Predicted GO
BP	GO:0045184	establishment of protein localization	IEP	Predicted GO
BP	GO:0046165	alcohol biosynthetic process	IEP	Predicted GO
BP	GO:0046173	polyol biosynthetic process	IEP	Predicted GO
BP	GO:0046907	intracellular transport	IEP	Predicted GO
MF	GO:0050662	coenzyme binding	IEP	Predicted GO
BP	GO:0051641	cellular localization	IEP	Predicted GO
BP	GO:0051649	establishment of localization in cell	IEP	Predicted GO
BP	GO:0070085	glycosylation	IEP	Predicted GO
BP	GO:0071702	organic substance transport	IEP	Predicted GO
BP	GO:0071705	nitrogen compound transport	IEP	Predicted GO
BP	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	IEP	Predicted GO
CC	GO:0098796	membrane protein complex	IEP	Predicted GO
BP	GO:1901264	carbohydrate derivative transport	IEP	Predicted GO
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Predicted GO
BP	GO:1901617	organic hydroxy compound biosynthetic process	IEP	Predicted GO
MF	GO:1901681	sulfur compound binding	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR003171	Mehydrof_redctse	6	301

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PSME_00013995-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation