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- Pseudotsuga menziesii
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- PSME_00015777-RA
PSME_00015777-RA
Description : (at5g55300 : 169.0) Encodes a type-I DNA topoisomerase I. Disruptions in this gene affect phyllotaxis and plant architecture suggesting that the gene plays a critical role in the maintenance of a regular pattern of organ initiation. Isolated as a protein oxidized during seed germination; proteomics approach revealed differences in de novo synthesis levels of this protein in condition with vs. without salicylic acid in the period from 0 to 40 hrs. following seed imbibition. Functions in stem cell maintenance at all stages of shoot and floral meristems and in the regulation of gene silencing.; DNA topoisomerase I alpha (TOP1ALPHA); FUNCTIONS IN: protein binding, DNA topoisomerase type I activity; INVOLVED IN: in 8 processes; LOCATED IN: chromosome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499); BEST Arabidopsis thaliana protein match is: DNA topoisomerase 1 beta (TAIR:AT5G55310.1). & (p93119|top1_dauca : 148.0) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) - Daucus carota (Carrot) & (reliability: 338.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
| Type | Description | Actions |
| Neighborhood | Pseudotsuga release: PSME_00015777-RA | |
| Cluster | HCCA clusters: Expression HeatmapCluster_53 | |
Functional Annotation
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0003674 | molecular_function | None | Extended |
| MF | GO:0003676 | nucleic acid binding | None | Extended |
| MF | GO:0003677 | DNA binding | IEA | InterProScan predictions |
| MF | GO:0003824 | catalytic activity | None | Extended |
| MF | GO:0003916 | DNA topoisomerase activity | None | Extended |
| MF | GO:0003917 | DNA topoisomerase type I activity | IEA | InterProScan predictions |
| MF | GO:0005488 | binding | None | Extended |
| CC | GO:0005575 | cellular_component | None | Extended |
| CC | GO:0005694 | chromosome | IEA | InterProScan predictions |
| BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
| BP | GO:0006259 | DNA metabolic process | None | Extended |
| BP | GO:0006265 | DNA topological change | IEA | InterProScan predictions |
| BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
| BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
| BP | GO:0006996 | organelle organization | None | Extended |
| BP | GO:0008150 | biological_process | None | Extended |
| BP | GO:0008152 | metabolic process | None | Extended |
| BP | GO:0009987 | cellular process | None | Extended |
| BP | GO:0016043 | cellular component organization | None | Extended |
| MF | GO:0016853 | isomerase activity | None | Extended |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
| BP | GO:0043170 | macromolecule metabolic process | None | Extended |
| CC | GO:0043226 | organelle | None | Extended |
| CC | GO:0043228 | non-membrane-bounded organelle | None | Extended |
| CC | GO:0043229 | intracellular organelle | None | Extended |
| CC | GO:0043232 | intracellular non-membrane-bounded organelle | None | Extended |
| BP | GO:0044237 | cellular metabolic process | None | Extended |
| BP | GO:0044238 | primary metabolic process | None | Extended |
| BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
| CC | GO:0044424 | intracellular part | None | Extended |
| CC | GO:0044464 | cell part | None | Extended |
| BP | GO:0046483 | heterocycle metabolic process | None | Extended |
| BP | GO:0051276 | chromosome organization | None | Extended |
| BP | GO:0071103 | DNA conformation change | None | Extended |
| BP | GO:0071704 | organic substance metabolic process | None | Extended |
| BP | GO:0071840 | cellular component organization or biogenesis | None | Extended |
| BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
| MF | GO:0097159 | organic cyclic compound binding | None | Extended |
| MF | GO:0140097 | catalytic activity, acting on DNA | None | Extended |
| BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
| MF | GO:1901363 | heterocyclic compound binding | None | Extended |
| Type | GO Term | Name | Evidence | Source |
| MF | GO:0000166 | nucleotide binding | IEP | Predicted GO |
| CC | GO:0005634 | nucleus | IEP | Predicted GO |
| BP | GO:0006260 | DNA replication | IEP | Predicted GO |
| BP | GO:0006855 | drug transmembrane transport | IEP | Predicted GO |
| BP | GO:0015893 | drug transport | IEP | Predicted GO |
| MF | GO:0036094 | small molecule binding | IEP | Predicted GO |
| MF | GO:0043168 | anion binding | IEP | Predicted GO |
| CC | GO:0043227 | membrane-bounded organelle | IEP | Predicted GO |
| CC | GO:0043231 | intracellular membrane-bounded organelle | IEP | Predicted GO |
| MF | GO:1901265 | nucleoside phosphate binding | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
| IPR008336 | TopoI_DNA-bd_euk | 161 | 268 |
