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  5. PSME_00016422-RA

PSME_00016422-RA


Description : (p50567|h2a_chlre : 85.5) Histone H2A - Chlamydomonas reinhardtii & (at1g08880 : 84.7) Encodes HTA5, a histone H2A protein. H2AX is a meiosis-specific isoform of histone H2A. Upon DSB formation, rapid accumulation of phosphorylated H2AX (γ-H2AX) occurs around the break site. H2AX foci accumulate in early G2. Immunolocalization studies in spread preparations of wild-type meiocytes at G2/early leptotene revealed the accumulation of numerous rather diffuse γ-H2AX foci throughout the chromatin. However, their accumulation is not contemporaneous with that of AtSPO11-1. At 3 h post-S, no γ-H2AX foci are detected. During the 3- to 5-h window when AtSPO11-1 foci rapidly disappear, there is an equally swift accumulation of γ-H2AX to a maximum of >50 diffuse foci. The level of γH2AX then remains constant for a further 13 h before undergoing a gradual decrease to 10ñ20 foci in the 18- to 24-h post-S period. By 30 h the foci have disappeared from the chromatin.; H2AXA; FUNCTIONS IN: DNA binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2A (InterPro:IPR002119), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: gamma histone variant H2AX (TAIR:AT1G54690.1); Has 3916 Blast hits to 3911 proteins in 363 species: Archae - 0; Bacteria - 0; Metazoa - 2550; Fungi - 318; Plants - 612; Viruses - 4; Other Eukaryotes - 432 (source: NCBI BLink). & (reliability: 169.4) & (original description: no original description)


Gene families : OG_42_0123948 (Orthogroups_2024-Update) Phylogenetic Tree(s): No tree available for this family

Sequence : coding (download), protein (download)


Attention: This gene has low abundance.


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood Pseudotsuga release: PSME_00016422-RA
Cluster HCCA clusters: Cluster_55


Type GO Term Name Evidence Source
CC GO:0000786 nucleosome IEA InterProScan predictions
MF GO:0003677 DNA binding IEA InterProScan predictions
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Type GO Term Name Evidence Source
MF GO:0004672 protein kinase activity IEP Predicted GO
MF GO:0005524 ATP binding IEP Predicted GO
BP GO:0006464 cellular protein modification process IEP Predicted GO
BP GO:0006468 protein phosphorylation IEP Predicted GO
BP GO:0006793 phosphorus metabolic process IEP Predicted GO
BP GO:0006796 phosphate-containing compound metabolic process IEP Predicted GO
BP GO:0006807 nitrogen compound metabolic process IEP Predicted GO
MF GO:0008144 drug binding IEP Predicted GO
BP GO:0009987 cellular process IEP Predicted GO
MF GO:0016301 kinase activity IEP Predicted GO
BP GO:0016310 phosphorylation IEP Predicted GO
MF GO:0016740 transferase activity IEP Predicted GO
MF GO:0016772 transferase activity, transferring phosphorus-containing groups IEP Predicted GO
MF GO:0016773 phosphotransferase activity, alcohol group as acceptor IEP Predicted GO
BP GO:0019538 protein metabolic process IEP Predicted GO
MF GO:0030246 carbohydrate binding IEP Predicted GO
MF GO:0030554 adenyl nucleotide binding IEP Predicted GO
MF GO:0032559 adenyl ribonucleotide binding IEP Predicted GO
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Predicted GO
BP GO:0036211 protein modification process IEP Predicted GO
BP GO:0043170 macromolecule metabolic process IEP Predicted GO
BP GO:0043412 macromolecule modification IEP Predicted GO
BP GO:0044237 cellular metabolic process IEP Predicted GO
BP GO:0044238 primary metabolic process IEP Predicted GO
BP GO:0044260 cellular macromolecule metabolic process IEP Predicted GO
BP GO:0044267 cellular protein metabolic process IEP Predicted GO
BP GO:0071704 organic substance metabolic process IEP Predicted GO
MF GO:0140096 catalytic activity, acting on a protein IEP Predicted GO
BP GO:1901564 organonitrogen compound metabolic process IEP Predicted GO
InterPro domains Description Start Stop
IPR007125 Histone_H2A/H2B/H3 23 66
IPR032454 Histone_H2A_C 69 102
No external refs found!