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- PSME_00018810-RA
PSME_00018810-RA
Description : (at3g24495 : 298.0) encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH7 exhibit moderate affinity for a (T/G) substrate and weak binding of (+T), suggesting MSH2*MSH7 may be specialized for lesions/base mispairs not tested or for (T/G) mispairs in special contexts.; MUTS homolog 7 (MSH7); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 17871 Blast hits to 13835 proteins in 2667 species: Archae - 197; Bacteria - 11731; Metazoa - 1028; Fungi - 1274; Plants - 566; Viruses - 3; Other Eukaryotes - 3072 (source: NCBI BLink). & (q9xgc9|msh2_maize : 143.0) DNA mismatch repair protein MSH2 (MUS1) - Zea mays (Maize) & (reliability: 596.0) & (original description: no original description)
Expression Profile
Attention: This gene has low abundance.
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Co-expression Networks
Type | Description | Actions |
Neighborhood | Pseudotsuga release: PSME_00018810-RA | |
Cluster | HCCA clusters: Cluster_71 | |
Expression Context Conservation (ECC)
Target | Alias | Description | ECC score | Gene Family Method | Actions |
PSME_00025175-RA | No alias | (at3g24495 : 128.0) encodes a DNA mismatch repair... | 0.03 | Orthogroups_2024-Update | |
Functional Annotation
Type | GO Term | Name | Evidence | Source |
MF | GO:0000166 | nucleotide binding | None | Extended |
MF | GO:0003674 | molecular_function | None | Extended |
MF | GO:0003676 | nucleic acid binding | None | Extended |
MF | GO:0003677 | DNA binding | None | Extended |
MF | GO:0003690 | double-stranded DNA binding | None | Extended |
MF | GO:0005488 | binding | None | Extended |
MF | GO:0005524 | ATP binding | IEA | InterProScan predictions |
BP | GO:0006139 | nucleobase-containing compound metabolic process | None | Extended |
BP | GO:0006259 | DNA metabolic process | None | Extended |
BP | GO:0006281 | DNA repair | None | Extended |
BP | GO:0006298 | mismatch repair | IEA | InterProScan predictions |
BP | GO:0006725 | cellular aromatic compound metabolic process | None | Extended |
BP | GO:0006807 | nitrogen compound metabolic process | None | Extended |
BP | GO:0006950 | response to stress | None | Extended |
BP | GO:0006974 | cellular response to DNA damage stimulus | None | Extended |
MF | GO:0008144 | drug binding | None | Extended |
BP | GO:0008150 | biological_process | None | Extended |
BP | GO:0008152 | metabolic process | None | Extended |
BP | GO:0009987 | cellular process | None | Extended |
MF | GO:0017076 | purine nucleotide binding | None | Extended |
MF | GO:0030554 | adenyl nucleotide binding | None | Extended |
MF | GO:0030983 | mismatched DNA binding | IEA | InterProScan predictions |
MF | GO:0032553 | ribonucleotide binding | None | Extended |
MF | GO:0032555 | purine ribonucleotide binding | None | Extended |
MF | GO:0032559 | adenyl ribonucleotide binding | None | Extended |
BP | GO:0033554 | cellular response to stress | None | Extended |
BP | GO:0034641 | cellular nitrogen compound metabolic process | None | Extended |
MF | GO:0035639 | purine ribonucleoside triphosphate binding | None | Extended |
MF | GO:0036094 | small molecule binding | None | Extended |
MF | GO:0043167 | ion binding | None | Extended |
MF | GO:0043168 | anion binding | None | Extended |
BP | GO:0043170 | macromolecule metabolic process | None | Extended |
BP | GO:0044237 | cellular metabolic process | None | Extended |
BP | GO:0044238 | primary metabolic process | None | Extended |
BP | GO:0044260 | cellular macromolecule metabolic process | None | Extended |
BP | GO:0046483 | heterocycle metabolic process | None | Extended |
BP | GO:0050896 | response to stimulus | None | Extended |
BP | GO:0051716 | cellular response to stimulus | None | Extended |
BP | GO:0071704 | organic substance metabolic process | None | Extended |
BP | GO:0090304 | nucleic acid metabolic process | None | Extended |
MF | GO:0097159 | organic cyclic compound binding | None | Extended |
MF | GO:0097367 | carbohydrate derivative binding | None | Extended |
MF | GO:1901265 | nucleoside phosphate binding | None | Extended |
BP | GO:1901360 | organic cyclic compound metabolic process | None | Extended |
MF | GO:1901363 | heterocyclic compound binding | None | Extended |
Type | GO Term | Name | Evidence | Source |
MF | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | IEP | Predicted GO |
MF | GO:0004650 | polygalacturonase activity | IEP | Predicted GO |
BP | GO:0005975 | carbohydrate metabolic process | IEP | Predicted GO |
MF | GO:0008194 | UDP-glycosyltransferase activity | IEP | Predicted GO |
MF | GO:0016759 | cellulose synthase activity | IEP | Predicted GO |
MF | GO:0016760 | cellulose synthase (UDP-forming) activity | IEP | Predicted GO |
MF | GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEP | Predicted GO |
BP | GO:0030243 | cellulose metabolic process | IEP | Predicted GO |
BP | GO:0030244 | cellulose biosynthetic process | IEP | Predicted GO |
MF | GO:0035251 | UDP-glucosyltransferase activity | IEP | Predicted GO |
InterPro domains | Description | Start | Stop |
IPR000432 | DNA_mismatch_repair_MutS_C | 87 | 300 |