Description : (at2g31660 : 249.0) SAD2 (super sensitive to ABA and drought 2) encodes an importin beta-domain family protein likely to be involved in nuclear transport in ABA signaling. Subcellular localization of GFP-tagged SAD2 showed a predominantly nuclear localization, consistent with a role for SAD2 in nuclear transport. Mutation of SAD2 in Arabidopsis alters abscisic acid sensitivity. SAD2 was ubiquitously expressed at low levels in all tissues except flowers. SAD2 expression was not induced by ABA or stress. Loss of function mutations in SAD2 exhibit increased tolerance for UV stress, increased production of UV protective secondary metabolites and suppression of nuclear localization of MYB4 (a repressor of UV stress response genes).; SUPER SENSITIVE TO ABA AND DROUGHT2 (SAD2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: protein import into nucleus, docking, protein import into nucleus; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-beta, N-terminal (InterPro:IPR001494), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Exportin/Importin, Cse1-like (InterPro:IPR013713); BEST Arabidopsis thaliana protein match is: ARM repeat superfamily protein (TAIR:AT3G59020.1); Has 3689 Blast hits to 2792 proteins in 293 species: Archae - 3; Bacteria - 183; Metazoa - 1271; Fungi - 834; Plants - 368; Viruses - 60; Other Eukaryotes - 970 (source: NCBI BLink). & (gnl|cdd|38754 : 98.3) no description available & (reliability: 498.0) & (original description: no original description)
Gene families : OG_42_0124606 (Orthogroups_2024-Update) Phylogenetic Tree(s): No tree available for this family
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00019934-RA | |
| Cluster | HCCA clusters: Cluster_228 |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
No GO annotation available for this sequence |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0004812 | aminoacyl-tRNA ligase activity | IEP | Predicted GO |
| MF | GO:0005524 | ATP binding | IEP | Predicted GO |
| CC | GO:0005575 | cellular_component | IEP | Predicted GO |
| BP | GO:0006270 | DNA replication initiation | IEP | Predicted GO |
| BP | GO:0006399 | tRNA metabolic process | IEP | Predicted GO |
| BP | GO:0006418 | tRNA aminoacylation for protein translation | IEP | Predicted GO |
| BP | GO:0006725 | cellular aromatic compound metabolic process | IEP | Predicted GO |
| BP | GO:0006778 | porphyrin-containing compound metabolic process | IEP | Predicted GO |
| BP | GO:0006779 | porphyrin-containing compound biosynthetic process | IEP | Predicted GO |
| BP | GO:0006783 | heme biosynthetic process | IEP | Predicted GO |
| BP | GO:0006784 | heme a biosynthetic process | IEP | Predicted GO |
| BP | GO:0006807 | nitrogen compound metabolic process | IEP | Predicted GO |
| MF | GO:0008144 | drug binding | IEP | Predicted GO |
| BP | GO:0008150 | biological_process | IEP | Predicted GO |
| BP | GO:0009058 | biosynthetic process | IEP | Predicted GO |
| MF | GO:0015399 | primary active transmembrane transporter activity | IEP | Predicted GO |
| MF | GO:0015405 | P-P-bond-hydrolysis-driven transmembrane transporter activity | IEP | Predicted GO |
| CC | GO:0016021 | integral component of membrane | IEP | Predicted GO |
| MF | GO:0016462 | pyrophosphatase activity | IEP | Predicted GO |
| MF | GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | IEP | Predicted GO |
| MF | GO:0016817 | hydrolase activity, acting on acid anhydrides | IEP | Predicted GO |
| MF | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEP | Predicted GO |
| MF | GO:0016875 | ligase activity, forming carbon-oxygen bonds | IEP | Predicted GO |
| MF | GO:0016887 | ATPase activity | IEP | Predicted GO |
| MF | GO:0017076 | purine nucleotide binding | IEP | Predicted GO |
| MF | GO:0017111 | nucleoside-triphosphatase activity | IEP | Predicted GO |
| BP | GO:0018130 | heterocycle biosynthetic process | IEP | Predicted GO |
| BP | GO:0019438 | aromatic compound biosynthetic process | IEP | Predicted GO |
| MF | GO:0022804 | active transmembrane transporter activity | IEP | Predicted GO |
| MF | GO:0030554 | adenyl nucleotide binding | IEP | Predicted GO |
| CC | GO:0031224 | intrinsic component of membrane | IEP | Predicted GO |
| MF | GO:0032553 | ribonucleotide binding | IEP | Predicted GO |
| MF | GO:0032555 | purine ribonucleotide binding | IEP | Predicted GO |
| MF | GO:0032559 | adenyl ribonucleotide binding | IEP | Predicted GO |
| BP | GO:0033013 | tetrapyrrole metabolic process | IEP | Predicted GO |
| BP | GO:0033014 | tetrapyrrole biosynthetic process | IEP | Predicted GO |
| BP | GO:0034641 | cellular nitrogen compound metabolic process | IEP | Predicted GO |
| MF | GO:0035639 | purine ribonucleoside triphosphate binding | IEP | Predicted GO |
| BP | GO:0042168 | heme metabolic process | IEP | Predicted GO |
| BP | GO:0042440 | pigment metabolic process | IEP | Predicted GO |
| MF | GO:0042623 | ATPase activity, coupled | IEP | Predicted GO |
| MF | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | IEP | Predicted GO |
| BP | GO:0043038 | amino acid activation | IEP | Predicted GO |
| BP | GO:0043039 | tRNA aminoacylation | IEP | Predicted GO |
| MF | GO:0043492 | ATPase activity, coupled to movement of substances | IEP | Predicted GO |
| BP | GO:0044237 | cellular metabolic process | IEP | Predicted GO |
| BP | GO:0044249 | cellular biosynthetic process | IEP | Predicted GO |
| BP | GO:0044271 | cellular nitrogen compound biosynthetic process | IEP | Predicted GO |
| CC | GO:0044425 | membrane part | IEP | Predicted GO |
| BP | GO:0046148 | pigment biosynthetic process | IEP | Predicted GO |
| BP | GO:0046160 | heme a metabolic process | IEP | Predicted GO |
| BP | GO:0046483 | heterocycle metabolic process | IEP | Predicted GO |
| BP | GO:0051186 | cofactor metabolic process | IEP | Predicted GO |
| BP | GO:0051188 | cofactor biosynthetic process | IEP | Predicted GO |
| BP | GO:0071704 | organic substance metabolic process | IEP | Predicted GO |
| BP | GO:0090304 | nucleic acid metabolic process | IEP | Predicted GO |
| MF | GO:0097367 | carbohydrate derivative binding | IEP | Predicted GO |
| MF | GO:0140101 | catalytic activity, acting on a tRNA | IEP | Predicted GO |
| BP | GO:1901360 | organic cyclic compound metabolic process | IEP | Predicted GO |
| BP | GO:1901362 | organic cyclic compound biosynthetic process | IEP | Predicted GO |
| BP | GO:1901564 | organonitrogen compound metabolic process | IEP | Predicted GO |
| BP | GO:1901566 | organonitrogen compound biosynthetic process | IEP | Predicted GO |
| BP | GO:1901576 | organic substance biosynthetic process | IEP | Predicted GO |
No InterPro domains available for this sequence
| No external refs found! |