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Description : (p28002|comt1_medsa : 130.0) Caffeic acid 3-O-methyltransferase (EC 2.1.1.68) (S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase) (COMT) (CAOMT) - Medicago sativa (Alfalfa) & (at5g54160 : 119.0) A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3Ã-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3Ã-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferase; O-methyltransferase 1 (OMT1); FUNCTIONS IN: myricetin 3'-O-methyltransferase activity, quercetin 3-O-methyltransferase activity, caffeate O-methyltransferase activity; INVOLVED IN: lignin biosynthetic process, flavonol biosynthetic process; LOCATED IN: cytosol, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Plant methyltransferase dimerisation (InterPro:IPR012967), O-methyltransferase, family 2 (InterPro:IPR001077), O-methyltransferase, COMT, eukaryota (InterPro:IPR016461); BEST Arabidopsis thaliana protein match is: O-methyltransferase family protein (TAIR:AT1G77520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). & (reliability: 238.0) & (original description: no original description)
Gene families : OG_42_0000016 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000016_tree
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
| Type | Description | Actions |
|---|---|---|
| Neighborhood | Pseudotsuga release: PSME_00021108-RA | |
| Cluster | HCCA clusters: Cluster_32 |
| Target | Alias | Description | ECC score | Gene Family Method | Actions |
|---|---|---|---|---|---|
| At1g76790 | No alias | Indole glucosinolate O-methyltransferase 5... | 0.02 | Orthogroups_2024-Update | |
| At5g37170 | No alias | O-methyltransferase family protein... | 0.02 | Orthogroups_2024-Update | |
| At5g54160 | No alias | Flavone 3'-O-methyltransferase 1... | 0.02 | Orthogroups_2024-Update | |
| Bradi2g02380 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| GRMZM2G017557 | No alias | O-methyltransferase family protein | 0.02 | Orthogroups_2024-Update | |
| Glyma.06G286700 | No alias | O-methyltransferase family protein | 0.03 | Orthogroups_2024-Update | |
| Glyma.09G281800 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| Glyma.10G176600 | No alias | O-methyltransferase family protein | 0.02 | Orthogroups_2024-Update | |
| Glyma.20G176100 | No alias | O-methyltransferase 1 | 0.03 | Orthogroups_2024-Update | |
| HORVU4Hr1G076050.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.03 | Orthogroups_2024-Update | |
| Kfl00216_0100 | kfl00216_0100_v1.1 | no hits & (original description: no original description) | 0.02 | Orthogroups_2024-Update | |
| LOC_Os09g17560 | No alias | O-methyltransferase, putative, expressed | 0.03 | Orthogroups_2024-Update | |
| LOC_Os10g02880 | No alias | O-methyltransferase, putative, expressed | 0.03 | Orthogroups_2024-Update | |
| MA_10432987g0020 | No alias | (p28002|comt1_medsa : 228.0) Caffeic acid... | 0.05 | Orthogroups_2024-Update | |
| MA_165197g0010 | No alias | (q8w013|comt1_catro : 372.0) Caffeic acid... | 0.03 | Orthogroups_2024-Update | |
| MA_1665780g0010 | No alias | no hits & (original description: no original description) | 0.04 | Orthogroups_2024-Update | |
| MA_5226589g0010 | No alias | no hits & (original description: no original description) | 0.04 | Orthogroups_2024-Update | |
| MA_749919g0010 | No alias | (p28002|comt1_medsa : 127.0) Caffeic acid... | 0.03 | Orthogroups_2024-Update | |
| MA_86945g0010 | No alias | (at5g54160 : 94.7) A caffeic acid/5-hydroxyferulic acid... | 0.03 | Orthogroups_2024-Update | |
| MA_9153751g0010 | No alias | (q8w013|comt1_catro : 164.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
| MA_9917746g0010 | No alias | (q9fqy8|comt1_capan : 178.0) Caffeic acid... | 0.07 | Orthogroups_2024-Update | |
| PSME_00006680-RA | No alias | (q9fqy8|comt1_capan : 424.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
| PSME_00012623-RA | No alias | (q8w013|comt1_catro : 272.0) Caffeic acid... | 0.04 | Orthogroups_2024-Update | |
| PSME_00035775-RA | No alias | (q8w013|comt1_catro : 165.0) Caffeic acid... | 0.03 | Orthogroups_2024-Update | |
| Potri.012G006400 | No alias | O-methyltransferase 1 | 0.02 | Orthogroups_2024-Update | |
| Potri.013G120800 | No alias | O-methyltransferase family protein | 0.03 | Orthogroups_2024-Update | |
| Seita.1G045400.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.05 | Orthogroups_2024-Update | |
| Seita.3G179100.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.02 | Orthogroups_2024-Update | |
| Seita.6G055900.1 | No alias | caffeic acid O-methyltransferase *(COMT) & EC_2.1... | 0.03 | Orthogroups_2024-Update | |
| Seita.7G073700.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.02 | Orthogroups_2024-Update | |
| Seita.8G093200.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.04 | Orthogroups_2024-Update | |
| Seita.9G374200.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.02 | Orthogroups_2024-Update | |
| Sobic.005G224400.1 | No alias | EC_2.1 transferase transferring one-carbon group | 0.04 | Orthogroups_2024-Update | |
| Solyc10g047520 | No alias | LOW QUALITY:O-methyltransferase (AHRD V3.3 *-* Q6VMV7_MENPI) | 0.03 | Orthogroups_2024-Update | |
| Solyc12g009110 | No alias | O-methyltransferase, putative (AHRD V3.3 *** B9SUX6_RICCO) | 0.02 | Orthogroups_2024-Update | |
| Solyc12g041950 | No alias | O-methyltransferase (AHRD V3.3 *-* G4XGX0_VITVI) | 0.04 | Orthogroups_2024-Update |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0046983 | protein dimerization activity | IEA | InterProScan predictions |
| Type | GO Term | Name | Evidence | Source |
|---|---|---|---|---|
| MF | GO:0000287 | magnesium ion binding | IEP | Predicted GO |
| MF | GO:0003824 | catalytic activity | IEP | Predicted GO |
| MF | GO:0005506 | iron ion binding | IEP | Predicted GO |
| BP | GO:0006081 | cellular aldehyde metabolic process | IEP | Predicted GO |
| BP | GO:0006629 | lipid metabolic process | IEP | Predicted GO |
| BP | GO:0006644 | phospholipid metabolic process | IEP | Predicted GO |
| BP | GO:0006720 | isoprenoid metabolic process | IEP | Predicted GO |
| MF | GO:0008168 | methyltransferase activity | IEP | Predicted GO |
| MF | GO:0008171 | O-methyltransferase activity | IEP | Predicted GO |
| BP | GO:0008299 | isoprenoid biosynthetic process | IEP | Predicted GO |
| BP | GO:0008610 | lipid biosynthetic process | IEP | Predicted GO |
| BP | GO:0008654 | phospholipid biosynthetic process | IEP | Predicted GO |
| BP | GO:0009240 | isopentenyl diphosphate biosynthetic process | IEP | Predicted GO |
| MF | GO:0010333 | terpene synthase activity | IEP | Predicted GO |
| MF | GO:0016491 | oxidoreductase activity | IEP | Predicted GO |
| MF | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEP | Predicted GO |
| MF | GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | IEP | Predicted GO |
| MF | GO:0016726 | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | IEP | Predicted GO |
| MF | GO:0016740 | transferase activity | IEP | Predicted GO |
| MF | GO:0016741 | transferase activity, transferring one-carbon groups | IEP | Predicted GO |
| MF | GO:0016829 | lyase activity | IEP | Predicted GO |
| MF | GO:0016835 | carbon-oxygen lyase activity | IEP | Predicted GO |
| MF | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates | IEP | Predicted GO |
| BP | GO:0019288 | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | IEP | Predicted GO |
| BP | GO:0019682 | glyceraldehyde-3-phosphate metabolic process | IEP | Predicted GO |
| MF | GO:0020037 | heme binding | IEP | Predicted GO |
| MF | GO:0043167 | ion binding | IEP | Predicted GO |
| MF | GO:0043169 | cation binding | IEP | Predicted GO |
| BP | GO:0044255 | cellular lipid metabolic process | IEP | Predicted GO |
| BP | GO:0046490 | isopentenyl diphosphate metabolic process | IEP | Predicted GO |
| MF | GO:0046872 | metal ion binding | IEP | Predicted GO |
| MF | GO:0046906 | tetrapyrrole binding | IEP | Predicted GO |
| MF | GO:0046914 | transition metal ion binding | IEP | Predicted GO |
| MF | GO:0048037 | cofactor binding | IEP | Predicted GO |
| BP | GO:0050992 | dimethylallyl diphosphate biosynthetic process | IEP | Predicted GO |
| BP | GO:0050993 | dimethylallyl diphosphate metabolic process | IEP | Predicted GO |
| MF | GO:0051745 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity | IEP | Predicted GO |
| BP | GO:0055114 | oxidation-reduction process | IEP | Predicted GO |
| InterPro domains | Description | Start | Stop |
|---|---|---|---|
| IPR012967 | Plant_MeTrfase_dimerisation | 49 | 101 |
| No external refs found! |