PSME_00022962-RA

Description : "(at3g44200 : 439.0) Encodes AtNek5, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.Interacts physically with plant kinesins ARK1 and ARK2. Mutants show defects in root epidermal cell morphology, trichome branching and other epidermal cell abnormalities suggesting a rol e in epidermal cell differentiation. NEK6 co-localizes with cortical microtubules.; ""NIMA (never in mitosis, gene A)-related 6"" (NEK6); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: microtubule-based process, epidermal cell differentiation; LOCATED IN: cortical microtubule; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related serine/threonine kinase 1 (TAIR:AT1G54510.3); Has 127749 Blast hits to 124714 proteins in 4408 species: Archae - 106; Bacteria - 14910; Metazoa - 47444; Fungi - 12949; Plants - 30417; Viruses - 519; Other Eukaryotes - 21404 (source: NCBI BLink). & (q5qn75|m2k1_orysa : 111.0) Mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK1) (OsMEK1) - Oryza sativa (Rice) & (reliability: 878.0) & (original description: no original description)"

Gene families : OG_42_0000572 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000572_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00022962-RA
Cluster	HCCA clusters: Cluster_108

Target	Alias	Description	ECC score	Gene Family Method
At3g44200	No alias	Serine/threonine-protein kinase Nek5...	0.04	Orthogroups_2024-Update
Bradi1g14070	No alias	NIMA-related kinase 2	0.02	Orthogroups_2024-Update
Bradi1g55730	No alias	NIMA-related kinase 2	0.02	Orthogroups_2024-Update
Cre13.g567550	No alias	NIMA (never in mitosis, gene A)-related 6	0.03	Orthogroups_2024-Update
GRMZM2G172900	No alias	NIMA-related kinase 5	0.02	Orthogroups_2024-Update
Glyma.10G029000	No alias	NIMA-related kinase 4	0.06	Orthogroups_2024-Update
Glyma.19G143000	No alias	NIMA-related kinase 5	0.04	Orthogroups_2024-Update
Glyma.19G159100	No alias	NIMA-related kinase 4	0.07	Orthogroups_2024-Update
HORVU1Hr1G074060.6	No alias	NEK protein kinase & EC_2.7 transferase transferring...	0.03	Orthogroups_2024-Update
Kfl00313_0090	kfl00313_0090_v1....	(at3g04810 : 171.0) Encodes AtNek2, a member of the...	0.02	Orthogroups_2024-Update
MA_127019g0010	No alias	"(at3g44200 : 469.0) Encodes AtNek5, a member of the...	0.03	Orthogroups_2024-Update
Seita.3G381600.1	No alias	NEK protein kinase & EC_2.7 transferase transferring...	0.02	Orthogroups_2024-Update
Sobic.001G160000.2	No alias	NEK protein kinase & EC_2.7 transferase transferring...	0.03	Orthogroups_2024-Update
Sobic.002G051000.1	No alias	NEK protein kinase & EC_2.7 transferase transferring...	0.02	Orthogroups_2024-Update
Solyc01g009300	No alias	Kinase (AHRD V3.3 *** D7LMI5_ARALL)	0.03	Orthogroups_2024-Update
Solyc01g097500	No alias	LSTK-1-like kinase	0.02	Orthogroups_2024-Update
Solyc11g071970	No alias	Protein kinase (AHRD V3.3 *** Q2HSJ8_MEDTR)	0.02	Orthogroups_2024-Update
evm.model.tig00000076.72	No alias	(at3g63280 : 165.0) Encodes AtNek4, a member of the...	0.01	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004672	protein kinase activity	IEA	InterProScan predictions
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	InterProScan predictions
BP	GO:0006464	cellular protein modification process	None	Extended
BP	GO:0006468	protein phosphorylation	IEA	InterProScan predictions
BP	GO:0006793	phosphorus metabolic process	None	Extended
BP	GO:0006796	phosphate-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016301	kinase activity	None	Extended
BP	GO:0016310	phosphorylation	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0036211	protein modification process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044267	cellular protein metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140096	catalytic activity, acting on a protein	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003905	alkylbase DNA N-glycosylase activity	IEP	Predicted GO
MF	GO:0005506	iron ion binding	IEP	Predicted GO
BP	GO:0006284	base-excision repair	IEP	Predicted GO
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Predicted GO
BP	GO:0006534	cysteine metabolic process	IEP	Predicted GO
BP	GO:0006535	cysteine biosynthetic process from serine	IEP	Predicted GO
BP	GO:0006563	L-serine metabolic process	IEP	Predicted GO
MF	GO:0008131	primary amine oxidase activity	IEP	Predicted GO
MF	GO:0008725	DNA-3-methyladenine glycosylase activity	IEP	Predicted GO
MF	GO:0008883	glutamyl-tRNA reductase activity	IEP	Predicted GO
MF	GO:0009001	serine O-acetyltransferase activity	IEP	Predicted GO
BP	GO:0009069	serine family amino acid metabolic process	IEP	Predicted GO
BP	GO:0009070	serine family amino acid biosynthetic process	IEP	Predicted GO
BP	GO:0009889	regulation of biosynthetic process	IEP	Predicted GO
BP	GO:0010468	regulation of gene expression	IEP	Predicted GO
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Predicted GO
MF	GO:0016412	serine O-acyltransferase activity	IEP	Predicted GO
MF	GO:0016413	O-acetyltransferase activity	IEP	Predicted GO
MF	GO:0016491	oxidoreductase activity	IEP	Predicted GO
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Predicted GO
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Predicted GO
MF	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEP	Predicted GO
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEP	Predicted GO
MF	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	IEP	Predicted GO
MF	GO:0019104	DNA N-glycosylase activity	IEP	Predicted GO
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Predicted GO
BP	GO:0019222	regulation of metabolic process	IEP	Predicted GO
BP	GO:0019344	cysteine biosynthetic process	IEP	Predicted GO
BP	GO:0031323	regulation of cellular metabolic process	IEP	Predicted GO
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Predicted GO
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Predicted GO
BP	GO:0033014	tetrapyrrole biosynthetic process	IEP	Predicted GO
MF	GO:0043169	cation binding	IEP	Predicted GO
MF	GO:0043733	DNA-3-methylbase glycosylase activity	IEP	Predicted GO
MF	GO:0046872	metal ion binding	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0048038	quinone binding	IEP	Predicted GO
MF	GO:0050660	flavin adenine dinucleotide binding	IEP	Predicted GO
MF	GO:0050661	NADP binding	IEP	Predicted GO
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Predicted GO
BP	GO:0051252	regulation of RNA metabolic process	IEP	Predicted GO
BP	GO:0055114	oxidation-reduction process	IEP	Predicted GO
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Predicted GO
BP	GO:0080090	regulation of primary metabolic process	IEP	Predicted GO
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Predicted GO
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Predicted GO
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR000719	Prot_kinase_dom	4	257

External Links

No external refs found!

PSME_00022962-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation