Description : "(at2g47460 : 219.0) ""MYB12 belongs to subgroup 7 of the R2R3-MYB family. It strongly activates the promoters of chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and - to a lesser extent - chalcone flavanone isomerase (CHI), but cannot activate the promoters of flavonoid-3'hydroxylase (F3'H) and dihydroflavonol 4-reductase (DF). The activation requires a functional MYB recognition element (MRE). Results from the myb12-1f allele indicate that an activation domain might be present in the C-terminus. Overexpression or knock-out plants do not show any obvious phenotype under greenhouse conditions. Young myb12-ko seedlings contain reduced amounts of flavonoids (quercetin and kaempferol), while seedlings as well as leaves of MYB12-OX plants displayed an increased flavonoid content. They did not show any significant difference in anthocyanin content. Expression of CHS and FLS shows a clear correlation to MYB12 expression levels. CHI and F3H show increased transcript levels in the MYB12-OX lines, but no differences in the knock-out. Even in the absence of functional MYB12, flavonol biosynthesis is not completely absent, suggesting functional redundancy. "" The redundant factors are MYB11 and MYB111 although MYB12 is primarily required for flavonol biosynthesis in roots.; myb domain protein 12 (MYB12); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 11 (TAIR:AT3G62610.1); Has 8833 Blast hits to 8133 proteins in 470 species: Archae - 0; Bacteria - 0; Metazoa - 786; Fungi - 423; Plants - 5965; Viruses - 6; Other Eukaryotes - 1653 (source: NCBI BLink). & (p27898|mybp_maize : 213.0) Myb-related protein P - Zea mays (Maize) & (reliability: 438.0) & (original description: no original description)"
Gene families : OG_42_0000002 (Orthogroups_2024-Update) Phylogenetic Tree(s): No tree available for this family
Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.
Type | Description | Actions |
---|---|---|
Neighborhood | Pseudotsuga release: PSME_00026136-RA | |
Cluster | HCCA clusters: Cluster_43 |
Target | Alias | Description | ECC score | Gene Family Method | Actions |
---|---|---|---|---|---|
A4A49_08715 | No alias | myb-related protein pp2 | 0.03 | Orthogroups_2024-Update | |
A4A49_11057 | No alias | transcription factor myb86 | 0.03 | Orthogroups_2024-Update | |
At4g17785 | No alias | Transcription factor MYB39... | 0.02 | Orthogroups_2024-Update | |
At5g40330 | No alias | Transcription factor MYB23... | 0.03 | Orthogroups_2024-Update | |
Bradi2g11676 | No alias | myb domain protein 12 | 0.02 | Orthogroups_2024-Update | |
Bradi5g15760 | No alias | myb domain protein 15 | 0.03 | Orthogroups_2024-Update | |
Brara.F01643.1 | No alias | MYB class-R2R3 subgroup-16 transcription factor &... | 0.03 | Orthogroups_2024-Update | |
Brara.G01033.1 | No alias | MYB class-R2R3 subgroup-4 transcription factor | 0.03 | Orthogroups_2024-Update | |
GRMZM2G158700 | No alias | myb domain protein 112 | 0.02 | Orthogroups_2024-Update | |
Glyma.05G040700 | No alias | myb domain protein 86 | 0.03 | Orthogroups_2024-Update | |
Glyma.11G194100 | No alias | myb domain protein 36 | 0.02 | Orthogroups_2024-Update | |
Glyma.17G031600 | No alias | myb domain protein 111 | 0.03 | Orthogroups_2024-Update | |
HORVU5Hr1G021750.2 | No alias | MYB class-R2R3 transcription factor | 0.03 | Orthogroups_2024-Update | |
HORVU6Hr1G067380.1 | No alias | MYB class-R2R3 subgroup-3 transcription factor | 0.03 | Orthogroups_2024-Update | |
LOC_Os04g50770 | No alias | MYB family transcription factor, putative, expressed | 0.03 | Orthogroups_2024-Update | |
MA_1589g0010 | No alias | (at1g63910 : 241.0) member of MYB3R- and R2R3- type MYB-... | 0.03 | Orthogroups_2024-Update | |
PSME_00014669-RA | No alias | (at1g22640 : 190.0) MYB-type transcription factor (MYB3)... | 0.04 | Orthogroups_2024-Update | |
PSME_00021697-RA | No alias | (at5g15310 : 302.0) Member of the R2R3 factor gene... | 0.04 | Orthogroups_2024-Update | |
PSME_00042064-RA | No alias | (p20026|myb1_horvu : 274.0) Myb-related protein Hv1 -... | 0.02 | Orthogroups_2024-Update | |
Potri.008G122100 | No alias | myb domain protein 62 | 0.02 | Orthogroups_2024-Update | |
Potri.010G149900 | No alias | myb domain protein 108 | 0.02 | Orthogroups_2024-Update | |
Seita.3G062400.1 | No alias | MYB class-R2R3 transcription factor | 0.03 | Orthogroups_2024-Update | |
Seita.5G274200.1 | No alias | MYB class-R2R3 subgroup-14 transcription factor | 0.03 | Orthogroups_2024-Update | |
Solyc05g053330 | No alias | MYB transcription factor (AHRD V3.3 *** Q39550_CRAPL) | 0.03 | Orthogroups_2024-Update | |
Sopen05g004950 | No alias | Myb-like DNA-binding domain | 0.03 | Orthogroups_2024-Update |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
No GO annotation available for this sequence |
Type | GO Term | Name | Evidence | Source |
---|---|---|---|---|
MF | GO:0004418 | hydroxymethylbilane synthase activity | IEP | Predicted GO |
MF | GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | IEP | Predicted GO |
CC | GO:0005643 | nuclear pore | IEP | Predicted GO |
BP | GO:0006405 | RNA export from nucleus | IEP | Predicted GO |
BP | GO:0006406 | mRNA export from nucleus | IEP | Predicted GO |
BP | GO:0007165 | signal transduction | IEP | Predicted GO |
MF | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IEP | Predicted GO |
MF | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors | IEP | Predicted GO |
MF | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor | IEP | Predicted GO |
MF | GO:0016790 | thiolester hydrolase activity | IEP | Predicted GO |
BP | GO:0016973 | poly(A)+ mRNA export from nucleus | IEP | Predicted GO |
MF | GO:0019207 | kinase regulator activity | IEP | Predicted GO |
MF | GO:0019887 | protein kinase regulator activity | IEP | Predicted GO |
BP | GO:0033013 | tetrapyrrole metabolic process | IEP | Predicted GO |
BP | GO:0033014 | tetrapyrrole biosynthetic process | IEP | Predicted GO |
MF | GO:0043531 | ADP binding | IEP | Predicted GO |
BP | GO:0050657 | nucleic acid transport | IEP | Predicted GO |
BP | GO:0050658 | RNA transport | IEP | Predicted GO |
BP | GO:0051028 | mRNA transport | IEP | Predicted GO |
BP | GO:0051168 | nuclear export | IEP | Predicted GO |
BP | GO:0051236 | establishment of RNA localization | IEP | Predicted GO |
No external refs found! |