PSME_00029110-RA

Description : (at1g72970 : 214.0) Originally identified as a mutation that causes floral organs to fuse together. About 10-20% of mutants also have defects in ovules. Mutants have reduced fertility most likely as because of fusions that pistil emergence. The protein has similarity to the mandelonitrile lyase family of FAD containing oxidoreductases and is predicted to be secreted (SignalP).It is expressed in all tissue layers of roots, inflorescences, stems, leaves, and flowers and is also expressed in siliques. Expression is highest in inflorescence and flower tissue.Transmission of mutant alleles to the progeny shows non mendelian segregation- a percentage of mutant alleles revert back to a previous parental (e.g. grandparental) wild type allele. It has been suggested that an RNA template driven or other extra-DNA genomic mechanism may be responsible for the non-mendelian inheritance of HTH. Reversion events in alleles at other loci have also been observed to occur in plants with an hth mutant background indicating a genome wide effect.; HOTHEAD (HTH); CONTAINS InterPro DOMAIN/s: Glucose-methanol-choline oxidoreductase, N-terminal (InterPro:IPR000172), Glucose-methanol-choline oxidoreductase (InterPro:IPR012132), Glucose-methanol-choline oxidoreductase, C-terminal (InterPro:IPR007867); BEST Arabidopsis thaliana protein match is: Glucose-methanol-choline (GMC) oxidoreductase family protein (TAIR:AT1G12570.1); Has 1244 Blast hits to 1228 proteins in 249 species: Archae - 2; Bacteria - 759; Metazoa - 27; Fungi - 277; Plants - 135; Viruses - 3; Other Eukaryotes - 41 (source: NCBI BLink). & (reliability: 428.0) & (original description: no original description)

Gene families : OG_42_0000273 (Orthogroups_2024-Update) Phylogenetic Tree(s): OG0000273_tree

Sequence : coding (download), protein (download)

Attention: This gene has low abundance.

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pseudotsuga release: PSME_00029110-RA
Cluster	HCCA clusters: Cluster_180

Target	Alias	Description	ECC score	Gene Family Method
235799	No alias	Glucose-methanol-choline (GMC) oxidoreductase family protein	0.03	Orthogroups_2024-Update
429523	No alias	Glucose-methanol-choline (GMC) oxidoreductase family protein	0.03	Orthogroups_2024-Update
A4A49_18141	No alias	protein hothead	0.04	Orthogroups_2024-Update
At5g51930	No alias	Glucose-methanol-choline (GMC) oxidoreductase family...	0.03	Orthogroups_2024-Update
Brara.B02049.1	No alias	Unknown function	0.02	Orthogroups_2024-Update
HORVU0Hr1G022360.1	No alias	Unknown function	0.03	Orthogroups_2024-Update
LOC_Os08g31030	No alias	HOTHEAD precursor, putative, expressed	0.02	Orthogroups_2024-Update
LOC_Os09g19930	No alias	HOTHEAD precursor, putative, expressed	0.02	Orthogroups_2024-Update
MA_111884g0010	No alias	(at1g14190 : 311.0) Glucose-methanol-choline (GMC)...	0.03	Orthogroups_2024-Update
MA_137064g0010	No alias	(at1g14190 : 357.0) Glucose-methanol-choline (GMC)...	0.03	Orthogroups_2024-Update
MA_9196249g0010	No alias	(at1g72970 : 113.0) Originally identified as a mutation...	0.03	Orthogroups_2024-Update
PSME_00032973-RA	No alias	(at1g12570 : 369.0) Glucose-methanol-choline (GMC)...	0.04	Orthogroups_2024-Update
PSME_00048296-RA	No alias	(at1g14190 : 439.0) Glucose-methanol-choline (GMC)...	0.04	Orthogroups_2024-Update
Potri.001G111500	No alias	Glucose-methanol-choline (GMC) oxidoreductase family protein	0.02	Orthogroups_2024-Update
Potri.010G168100	No alias	Glucose-methanol-choline (GMC) oxidoreductase family protein	0.03	Orthogroups_2024-Update
Potri.010G168200	No alias	Glucose-methanol-choline (GMC) oxidoreductase family protein	0.02	Orthogroups_2024-Update
Seita.9G565000.1	No alias	Unknown function	0.02	Orthogroups_2024-Update
Solyc03g121600	No alias	Glucose-methanol-choline (GMC) oxidoreductase family...	0.03	Orthogroups_2024-Update
Sopen06g022090	No alias	GMC oxidoreductase	0.04	Orthogroups_2024-Update

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEA	InterProScan predictions
BP	GO:0055114	oxidation-reduction process	IEA	InterProScan predictions

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Predicted GO
MF	GO:0003885	D-arabinono-1,4-lactone oxidase activity	IEP	Predicted GO
BP	GO:0006464	cellular protein modification process	IEP	Predicted GO
BP	GO:0006508	proteolysis	IEP	Predicted GO
BP	GO:0006807	nitrogen compound metabolic process	IEP	Predicted GO
MF	GO:0008233	peptidase activity	IEP	Predicted GO
MF	GO:0008234	cysteine-type peptidase activity	IEP	Predicted GO
BP	GO:0016579	protein deubiquitination	IEP	Predicted GO
MF	GO:0016740	transferase activity	IEP	Predicted GO
MF	GO:0016746	transferase activity, transferring acyl groups	IEP	Predicted GO
MF	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	IEP	Predicted GO
MF	GO:0017076	purine nucleotide binding	IEP	Predicted GO
BP	GO:0019538	protein metabolic process	IEP	Predicted GO
MF	GO:0019783	ubiquitin-like protein-specific protease activity	IEP	Predicted GO
MF	GO:0030554	adenyl nucleotide binding	IEP	Predicted GO
MF	GO:0032555	purine ribonucleotide binding	IEP	Predicted GO
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Predicted GO
MF	GO:0036094	small molecule binding	IEP	Predicted GO
BP	GO:0036211	protein modification process	IEP	Predicted GO
MF	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEP	Predicted GO
MF	GO:0043167	ion binding	IEP	Predicted GO
MF	GO:0043168	anion binding	IEP	Predicted GO
BP	GO:0043170	macromolecule metabolic process	IEP	Predicted GO
BP	GO:0043412	macromolecule modification	IEP	Predicted GO
MF	GO:0043531	ADP binding	IEP	Predicted GO
BP	GO:0044237	cellular metabolic process	IEP	Predicted GO
BP	GO:0044238	primary metabolic process	IEP	Predicted GO
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Predicted GO
BP	GO:0044267	cellular protein metabolic process	IEP	Predicted GO
MF	GO:0048037	cofactor binding	IEP	Predicted GO
MF	GO:0050660	flavin adenine dinucleotide binding	IEP	Predicted GO
MF	GO:0070011	peptidase activity, acting on L-amino acid peptides	IEP	Predicted GO
BP	GO:0070646	protein modification by small protein removal	IEP	Predicted GO
BP	GO:0070647	protein modification by small protein conjugation or removal	IEP	Predicted GO
BP	GO:0071704	organic substance metabolic process	IEP	Predicted GO
MF	GO:0097159	organic cyclic compound binding	IEP	Predicted GO
MF	GO:0101005	ubiquitinyl hydrolase activity	IEP	Predicted GO
MF	GO:0140096	catalytic activity, acting on a protein	IEP	Predicted GO
MF	GO:1901265	nucleoside phosphate binding	IEP	Predicted GO
MF	GO:1901363	heterocyclic compound binding	IEP	Predicted GO
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR007867	GMC_OxRtase_C	34	180

External Links

No external refs found!

PSME_00029110-RA

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation